Immunology presentation at the 1990 NASA/NSF Antarctica Biomedical Science Working Group
An overview of methodology used for determining human in vitro lymphocyte activation, proliferation and effector cell function was presented and results of previous manned space flight immunology studies from Apollo through Shuttle were reviewed. Until the Shuttle era, lymphocyte assays were not ver...
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ftnasantrs:oai:casi.ntrs.nasa.gov:19930007617 2023-05-15T13:42:52+02:00 Immunology presentation at the 1990 NASA/NSF Antarctica Biomedical Science Working Group Meehan, Richard T. Unclassified, Unlimited, Publicly available Oct 11, 1990 application/pdf http://hdl.handle.net/2060/19930007617 unknown Document ID: 19930007617 Accession ID: 93N16806 http://hdl.handle.net/2060/19930007617 No Copyright CASI LIFE SCIENCES (GENERAL) NASA. Headquarters, Biomedical Polar Research Workshop Minutes; 4 p 1990 ftnasantrs 2015-03-15T04:38:10Z An overview of methodology used for determining human in vitro lymphocyte activation, proliferation and effector cell function was presented and results of previous manned space flight immunology studies from Apollo through Shuttle were reviewed. Until the Shuttle era, lymphocyte assays were not very sensitive and had such large variations among normal subjects that it was difficult to define a consistent effect of space flight. More sensitive assay, however, even with Shuttle missions as brief as 6 days indicate depressed T-cell proliferative responses are routinely observed following space flight. Using a slight modification of the Shuttle assay, five different human stress-immunology models have been studied over the last 6 years in our lab. These have included: academic examinations of medical students having blood drawn during major test periods on three separate groups of first year students and two hypoxia studies (at 25,000 feet in a 6 week chamber ascent to the equivalent of Mount Everest and twice on Pikes Peak at 14,000 feet). These studies are particularly pertinent to Antarctica, since the altitude equivalent of 11,000 feet at the South Pole may affect some of the variables that are being measured in immunology, physiology or cognitive studies. An extravehicular study was performed drawing blood from 35 individuals before and immediately following a chamber exposure study. Preliminary results from 30 Shuttle astronauts investigated immunophenotype analysis and the role of a novel monocyte population in modulating the previously observed suppressed in vitro immune function. The results of the Air Force Academy cadet stress study were also presented. Other/Unknown Material Antarc* Antarctica South pole South pole NASA Technical Reports Server (NTRS) South Pole |
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Open Polar |
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NASA Technical Reports Server (NTRS) |
op_collection_id |
ftnasantrs |
language |
unknown |
topic |
LIFE SCIENCES (GENERAL) |
spellingShingle |
LIFE SCIENCES (GENERAL) Meehan, Richard T. Immunology presentation at the 1990 NASA/NSF Antarctica Biomedical Science Working Group |
topic_facet |
LIFE SCIENCES (GENERAL) |
description |
An overview of methodology used for determining human in vitro lymphocyte activation, proliferation and effector cell function was presented and results of previous manned space flight immunology studies from Apollo through Shuttle were reviewed. Until the Shuttle era, lymphocyte assays were not very sensitive and had such large variations among normal subjects that it was difficult to define a consistent effect of space flight. More sensitive assay, however, even with Shuttle missions as brief as 6 days indicate depressed T-cell proliferative responses are routinely observed following space flight. Using a slight modification of the Shuttle assay, five different human stress-immunology models have been studied over the last 6 years in our lab. These have included: academic examinations of medical students having blood drawn during major test periods on three separate groups of first year students and two hypoxia studies (at 25,000 feet in a 6 week chamber ascent to the equivalent of Mount Everest and twice on Pikes Peak at 14,000 feet). These studies are particularly pertinent to Antarctica, since the altitude equivalent of 11,000 feet at the South Pole may affect some of the variables that are being measured in immunology, physiology or cognitive studies. An extravehicular study was performed drawing blood from 35 individuals before and immediately following a chamber exposure study. Preliminary results from 30 Shuttle astronauts investigated immunophenotype analysis and the role of a novel monocyte population in modulating the previously observed suppressed in vitro immune function. The results of the Air Force Academy cadet stress study were also presented. |
format |
Other/Unknown Material |
author |
Meehan, Richard T. |
author_facet |
Meehan, Richard T. |
author_sort |
Meehan, Richard T. |
title |
Immunology presentation at the 1990 NASA/NSF Antarctica Biomedical Science Working Group |
title_short |
Immunology presentation at the 1990 NASA/NSF Antarctica Biomedical Science Working Group |
title_full |
Immunology presentation at the 1990 NASA/NSF Antarctica Biomedical Science Working Group |
title_fullStr |
Immunology presentation at the 1990 NASA/NSF Antarctica Biomedical Science Working Group |
title_full_unstemmed |
Immunology presentation at the 1990 NASA/NSF Antarctica Biomedical Science Working Group |
title_sort |
immunology presentation at the 1990 nasa/nsf antarctica biomedical science working group |
publishDate |
1990 |
url |
http://hdl.handle.net/2060/19930007617 |
op_coverage |
Unclassified, Unlimited, Publicly available |
geographic |
South Pole |
geographic_facet |
South Pole |
genre |
Antarc* Antarctica South pole South pole |
genre_facet |
Antarc* Antarctica South pole South pole |
op_source |
CASI |
op_relation |
Document ID: 19930007617 Accession ID: 93N16806 http://hdl.handle.net/2060/19930007617 |
op_rights |
No Copyright |
_version_ |
1766173672642445312 |