Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic
Woolly mammoths and living elephants are characterized by major phenotypic differences that have allowed them to live in very different environments. To identify the genetic changes that underlie the suite of woolly mammoth adaptations to extreme cold, we sequenced the nuclear genome from three Asia...
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ftnanyangtu:oai:dr.ntu.edu.sg:10356/103508 2023-05-15T14:25:49+02:00 Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic Lynch, Vincent J. Bedoya-Reina, Oscar C. Ratan, Aakrosh Sulak, Michael Drautz-Moses, Daniela I. Perry, George H. Miller, Webb Schuster, Stephan C. Singapore Centre for Environmental Life Sciences Engineering 2015-10-01T07:32:01Z application/pdf https://hdl.handle.net/10356/103508 http://hdl.handle.net/10220/38768 https://doi.org/10.1016/j.celrep.2015.06.027 en eng Cell Reports Lynch, V., Bedoya-Reina, O., Ratan, A., Sulak, M., Drautz-Moses, D., et al. (2015). Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic. Cell Reports, 12(2), 217-228. 2211-1247 https://hdl.handle.net/10356/103508 http://hdl.handle.net/10220/38768 doi:10.1016/j.celrep.2015.06.027 © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). CC-BY-NC-ND Journal Article 2015 ftnanyangtu https://doi.org/10.1016/j.celrep.2015.06.027 2020-09-25T00:08:47Z Woolly mammoths and living elephants are characterized by major phenotypic differences that have allowed them to live in very different environments. To identify the genetic changes that underlie the suite of woolly mammoth adaptations to extreme cold, we sequenced the nuclear genome from three Asian elephants and two woolly mammoths, and we identified and functionally annotated genetic changes unique to woolly mammoths. We found that genes with mammoth-specific amino acid changes are enriched in functions related to circadian biology, skin and hair development and physiology, lipid metabolism, adipose development and physiology, and temperature sensation. Finally, we resurrected and functionally tested the mammoth and ancestral elephant TRPV3 gene, which encodes a temperature-sensitive transient receptor potential (thermoTRP) channel involved in thermal sensation and hair growth, and we show that a single mammoth-specific amino acid substitution in an otherwise highly conserved region of the TRPV3 channel strongly affects its temperature sensitivity. Published version Article in Journal/Newspaper Arctic Arctic DR-NTU (Digital Repository at Nanyang Technological University, Singapore) Arctic Cell Reports 12 2 217 228 |
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DR-NTU (Digital Repository at Nanyang Technological University, Singapore) |
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ftnanyangtu |
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English |
description |
Woolly mammoths and living elephants are characterized by major phenotypic differences that have allowed them to live in very different environments. To identify the genetic changes that underlie the suite of woolly mammoth adaptations to extreme cold, we sequenced the nuclear genome from three Asian elephants and two woolly mammoths, and we identified and functionally annotated genetic changes unique to woolly mammoths. We found that genes with mammoth-specific amino acid changes are enriched in functions related to circadian biology, skin and hair development and physiology, lipid metabolism, adipose development and physiology, and temperature sensation. Finally, we resurrected and functionally tested the mammoth and ancestral elephant TRPV3 gene, which encodes a temperature-sensitive transient receptor potential (thermoTRP) channel involved in thermal sensation and hair growth, and we show that a single mammoth-specific amino acid substitution in an otherwise highly conserved region of the TRPV3 channel strongly affects its temperature sensitivity. Published version |
author2 |
Singapore Centre for Environmental Life Sciences Engineering |
format |
Article in Journal/Newspaper |
author |
Lynch, Vincent J. Bedoya-Reina, Oscar C. Ratan, Aakrosh Sulak, Michael Drautz-Moses, Daniela I. Perry, George H. Miller, Webb Schuster, Stephan C. |
spellingShingle |
Lynch, Vincent J. Bedoya-Reina, Oscar C. Ratan, Aakrosh Sulak, Michael Drautz-Moses, Daniela I. Perry, George H. Miller, Webb Schuster, Stephan C. Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic |
author_facet |
Lynch, Vincent J. Bedoya-Reina, Oscar C. Ratan, Aakrosh Sulak, Michael Drautz-Moses, Daniela I. Perry, George H. Miller, Webb Schuster, Stephan C. |
author_sort |
Lynch, Vincent J. |
title |
Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic |
title_short |
Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic |
title_full |
Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic |
title_fullStr |
Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic |
title_full_unstemmed |
Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic |
title_sort |
elephantid genomes reveal the molecular bases of woolly mammoth adaptations to the arctic |
publishDate |
2015 |
url |
https://hdl.handle.net/10356/103508 http://hdl.handle.net/10220/38768 https://doi.org/10.1016/j.celrep.2015.06.027 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Arctic |
genre_facet |
Arctic Arctic |
op_relation |
Cell Reports Lynch, V., Bedoya-Reina, O., Ratan, A., Sulak, M., Drautz-Moses, D., et al. (2015). Elephantid Genomes Reveal the Molecular Bases of Woolly Mammoth Adaptations to the Arctic. Cell Reports, 12(2), 217-228. 2211-1247 https://hdl.handle.net/10356/103508 http://hdl.handle.net/10220/38768 doi:10.1016/j.celrep.2015.06.027 |
op_rights |
© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.celrep.2015.06.027 |
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Cell Reports |
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12 |
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2 |
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217 |
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228 |
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1766298276173185024 |