| Summary: | Nagasaki University (長崎大学) 博士(医学) Daptomycin is inactivated by pulmonary surfactant, but its effectiveness in hematogenous pulmonary infection has been poorly studied. The potential therapeutic application was evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) hematogenous pulmonary infection mouse model. Compared with control results, daptomycin improved survival (P<0.001) and decreased the number of abscesses and bacteria in the lungs (P<0.01). Daptomycin may be an effective therapeutic option for MRSA hematogenous pulmonary infection. 長崎大学学位論文 学位記番号:博(医歯薬)甲第688号 学位授与年月日:平成26年3月20日 Author: Harada Yosuke, Yanagihara Katsunori, Yamada Koichi, Migiyama Yohei, Nagaoka Kentaro, Morinaga Yoshitomo, Nakamura Shigeki, Imamura Yoshifumi, Hasegawa Hiroo, Miyazaki Taiga, Izumikawa Koichi, Kakeya Hiroshi, Kohno Shigeru Citation: Antimicrobial Agents and Chemotherapy, 57(6), pp.2841-2844; 2013 Nagasaki University (長崎大学), 博士(医学) (2014-03-20) doctoral thesis
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