重症熱性血小板減少症候群による世界最初の生存例および死亡例の2症例の病態解析：および長崎における疫学的研究

• Main Author: 栗原, 慎太郎
• Format: Other/Unknown Material
• Language: English
• Published: Elsevier 2016
• Subjects: Severe fever with thrombocytopenia syndrome; First cases; Epidemiology; Antibody; taiga
• Online Access: https://nagasaki-u.repo.nii.ac.jp/record/3757/files/ISYK880_Kurihara.pdf

Nagasaki University (長崎大学) 博士(医学) Severe fever with thrombocytopenia syndrome (SFTS) caused by the SFTS virus (SFTSV), a novel phlebovirus belonging to the family Bunyaviridae, was reported in China for the first time in 2009. We observed two cases where the SFTSV was isolated for the first time in Nagasaki, Japan, in 2005. Two males in their 60s, a farmer and a hunter, respectively, living in Nagasaki developed SFTS during the same period. The patients developed similar clinical symptoms and signs, such as fever, loss of consciousness, and multiple organ dysfunction. The farmer died and the hunter survived. A retrospective diagnosis of SFTS was made in 2013, and genetic analysis revealed that the patients were infected with different SFTSV strains. Retrospective analysis of cytokine production in non-fatal case revealed interleukin (IL)-6, IL-8 and interferon-γ level of acute phase was low and could be potential prognostic factors. As there are no epidemiological studies of positive rate of SFTSV antibody in people living in endemic areas in Japan, a field study was performed. Volunteers at high risk for tick bites, such as hunters, farmers, and soldiers, were recruited in 6 regions, including the areas where the SFTS cases occurred. Three hundred and twenty six volunteers in Nagasaki prefecture were examined and none of these tested positive for the SFTSV antibody. Our data indicates that the risk for SFTSV infection is not high in Nagasaki prefecture. Further collection of blood samples from endemic areas is warranted for the prevention of SFTSV infection. 長崎大学学位論文 学位記番号:博(医歯薬)甲第880号 学位授与年月日:平成28年8月3日 Author: Shintaro Kurihara, Akira Satoh, Fuxun Yu, Daisuke Hayasaka, Masayuki Shimojima, Masato Tashiro, Tomomi Saijo, Takahiro Takazono, Yoshifumi Imamura, Taiga Miyazaki, Misuzu Tsukamoto, Katsunori Yanagihara, Hiroshi Mukae, Masayuki Saijo, Kouichi Morita, Shigeru Kohno, Koichi Izumikawa Citation: Journal of Infection and Chemotherapy, 22(7), pp.461-465; 2016 Nagasaki University (長崎大学), 博士(医学) ...