QRDR変異を有する肺炎球菌に対するラスクフロキサシンのインビトロ活性の評価

Nagasaki University (長崎大学) 博士(医学) Lascufloxacin showed potent activity against Streptococcus pneumoniae with a GyrA or ParC mutation (first-step mutant). The frequency of selecting resistant strains tended to be lower for lascufloxacin than for levofloxacin and garenoxacin after drug exposure in fir...

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Main Author: 村田, 美香
Format: Other/Unknown Material
Language:English
Published: American Society for Microbiology 2019
Subjects:
lascufloxacin
Streptococcus pneumoniae
fluoroquinolone resistance
taiga
Online Access:https://nagasaki-u.repo.nii.ac.jp/record/1974/files/ISYK1138_Murata.pdf
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spelling ftnagasakiuniv:oai:nagasaki-u.repo.nii.ac.jp:00001974 2023-09-26T15:23:39+02:00 QRDR変異を有する肺炎球菌に対するラスクフロキサシンのインビトロ活性の評価 In Vitro Activity of Lascufloxacin against Streptococcus pneumoniae with Mutations in the Quinolone Resistance-Determining Regions 村田, 美香 2019-03-20 application/pdf https://nagasaki-u.repo.nii.ac.jp/record/1974/files/ISYK1138_Murata.pdf eng eng American Society for Microbiology 10.1128/AAC.01971-17 http://hdl.handle.net/10069/39027 Antimicrobial Agents and Chemotherapy 4 62 e01971-17 甲医歯薬第1138号 00664804 10986596 https://nagasaki-u.repo.nii.ac.jp/record/1974/files/ISYK1138_Murata.pdf c 2018 American Society for Microbiology open access lascufloxacin Streptococcus pneumoniae fluoroquinolone resistance VoR 2019 ftnagasakiuniv 2023-08-25T00:03:27Z Nagasaki University (長崎大学) 博士(医学) Lascufloxacin showed potent activity against Streptococcus pneumoniae with a GyrA or ParC mutation (first-step mutant). The frequency of selecting resistant strains tended to be lower for lascufloxacin than for levofloxacin and garenoxacin after drug exposure in first-step mutants but was similar in the comparison between lascufloxacin and moxifloxacin. The increase in MIC was smaller for lascufloxacin than for levofloxacin, garenoxacin, and moxifloxacin when clinical strains with only ParC mutations were exposed to the corresponding drug. 長崎大学学位論文 学位記番号:博(医歯薬)甲第1138号 学位授与年月日:平成31年3月20日 Author: Mika Murata, Kosuke Kosai, Shunsuke Yamauchi, Daisuke Sasaki, Norihito Kaku, Naoki Uno, Yoshitomo Morinaga, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara Citation: Antimicrobial Agents and Chemotherapy, 62(4), e01971-17; 2018 Nagasaki University (長崎大学), 博士(医学) (2019-03-20) doctoral thesis Other/Unknown Material taiga NAOSITE: Nagasaki University Academic Output SITE
institution Open Polar
collection NAOSITE: Nagasaki University Academic Output SITE
op_collection_id ftnagasakiuniv
language English
topic lascufloxacin
Streptococcus pneumoniae
fluoroquinolone resistance
spellingShingle lascufloxacin
Streptococcus pneumoniae
fluoroquinolone resistance
村田, 美香
QRDR変異を有する肺炎球菌に対するラスクフロキサシンのインビトロ活性の評価
topic_facet lascufloxacin
Streptococcus pneumoniae
fluoroquinolone resistance
description Nagasaki University (長崎大学) 博士(医学) Lascufloxacin showed potent activity against Streptococcus pneumoniae with a GyrA or ParC mutation (first-step mutant). The frequency of selecting resistant strains tended to be lower for lascufloxacin than for levofloxacin and garenoxacin after drug exposure in first-step mutants but was similar in the comparison between lascufloxacin and moxifloxacin. The increase in MIC was smaller for lascufloxacin than for levofloxacin, garenoxacin, and moxifloxacin when clinical strains with only ParC mutations were exposed to the corresponding drug. 長崎大学学位論文 学位記番号:博(医歯薬)甲第1138号 学位授与年月日:平成31年3月20日 Author: Mika Murata, Kosuke Kosai, Shunsuke Yamauchi, Daisuke Sasaki, Norihito Kaku, Naoki Uno, Yoshitomo Morinaga, Hiroo Hasegawa, Taiga Miyazaki, Koichi Izumikawa, Hiroshi Mukae, Katsunori Yanagihara Citation: Antimicrobial Agents and Chemotherapy, 62(4), e01971-17; 2018 Nagasaki University (長崎大学), 博士(医学) (2019-03-20) doctoral thesis
format Other/Unknown Material
author 村田, 美香
author_facet 村田, 美香
author_sort 村田, 美香
title QRDR変異を有する肺炎球菌に対するラスクフロキサシンのインビトロ活性の評価
title_short QRDR変異を有する肺炎球菌に対するラスクフロキサシンのインビトロ活性の評価
title_full QRDR変異を有する肺炎球菌に対するラスクフロキサシンのインビトロ活性の評価
title_fullStr QRDR変異を有する肺炎球菌に対するラスクフロキサシンのインビトロ活性の評価
title_full_unstemmed QRDR変異を有する肺炎球菌に対するラスクフロキサシンのインビトロ活性の評価
title_sort qrdr変異を有する肺炎球菌に対するラスクフロキサシンのインビトロ活性の評価
publisher American Society for Microbiology
publishDate 2019
url https://nagasaki-u.repo.nii.ac.jp/record/1974/files/ISYK1138_Murata.pdf
genre taiga
genre_facet taiga
op_relation 10.1128/AAC.01971-17
http://hdl.handle.net/10069/39027
Antimicrobial Agents and Chemotherapy
4
62
e01971-17
甲医歯薬第1138号
00664804
10986596
https://nagasaki-u.repo.nii.ac.jp/record/1974/files/ISYK1138_Murata.pdf
op_rights c 2018 American Society for Microbiology
open access
_version_ 1778149925448581120

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