腹膜線維症存在下でのカンジダ腹膜炎マウスモデルを用いた、腹膜線維症がカンジダ腹膜炎に及ぼす影響とミカファンギンによる治療効果の評価

Nagasaki University (長崎大学) 博士(医学) Candida peritonitis is a crucial disease, however the optimal antifungal therapy regimen has not been clearly defined. Peritoneal fibrosis (PF) can be caused by abdominal surgery, intra-abdominal infection, and malignant diseases, and is also widely recognized as a...

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Main Author: 芦澤, 信之
Format: Other/Unknown Material
Language:English
Published: Springer Nature 2019
Subjects:
taiga
Online Access:https://nagasaki-u.repo.nii.ac.jp/record/277/files/ISYK1180_Ashizawa.pdf
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spelling ftnagasakiuniv:oai:nagasaki-u.repo.nii.ac.jp:00000277 2023-09-26T15:23:39+02:00 腹膜線維症存在下でのカンジダ腹膜炎マウスモデルを用いた、腹膜線維症がカンジダ腹膜炎に及ぼす影響とミカファンギンによる治療効果の評価 Evaluation of Candida peritonitis with underlying peritoneal fibrosis and efficacy of micafungin in murine models of intra-abdominal candidiasis 芦澤, 信之 2019-09-04 application/pdf https://nagasaki-u.repo.nii.ac.jp/record/277/files/ISYK1180_Ashizawa.pdf eng eng Springer Nature 10.1038/s41598-019-45776-x http://hdl.handle.net/10069/39479 Scientific Reports 9 9331 甲医歯薬第1180号 20452322 https://nagasaki-u.repo.nii.ac.jp/record/277/files/ISYK1180_Ashizawa.pdf c 2019, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. open access VoR 2019 ftnagasakiuniv 2023-08-25T00:07:02Z Nagasaki University (長崎大学) 博士(医学) Candida peritonitis is a crucial disease, however the optimal antifungal therapy regimen has not been clearly defined. Peritoneal fibrosis (PF) can be caused by abdominal surgery, intra-abdominal infection, and malignant diseases, and is also widely recognized as a crucial complication of long-term peritoneal dialysis. However, the influence of PF on Candida peritonitis prognosis remains unknown. Here, we evaluated the severity of Candida peritonitis within the context of PF and the efficacy of micafungin using mice. A PF mouse model was generated by intraperitoneally administering chlorhexidine gluconate. Candida peritonitis, induced by intraperitoneal inoculation of Candida albicans, was treated with a 7-day consecutive subcutaneous administration of micafungin. Candida infection caused a higher mortality rate in the PF mice compared with the control mice on day 7. Proliferative Candida invasion into the peritoneum and intra-abdominal organs was confirmed pathologically only in the PF mice. However, all mice in both groups treated with micafungin survived until day 20. Micafungin treatment tends to suppress inflammatory cytokines in the plasma 12?h after infection in both groups. Our results suggest that PF enhances early mortality in Candida peritonitis. Prompt initiation and sufficient doses of micafungin had good efficacy for Candida peritonitis, irrespective of the underlying PF. 長崎大学学位論文 学位記番号:博(医歯薬)甲第1180号 学位授与年月日:令和元年9月4日 Author: Nobuyuki Ashizawa, Taiga Miyazaki, Shinichi Abe, Takahiro Takazono, Tomomi Saijo, Yoko Obata, Shintaro Shimamura, Kazuko Yamamoto, Yoshifumi Imamura, Takehiko Koji, Tomoya Nishino, Koichi Izumikawa, Katsunori Yanagihara, Shigeru Kohno & Hiroshi Mukae Citation: Scientific Reports, 9, 9331; 2019 Nagasaki University (長崎大学), 博士(医学) (2019-09-04) doctoral thesis Other/Unknown Material taiga NAOSITE: Nagasaki University Academic Output SITE
institution Open Polar
collection NAOSITE: Nagasaki University Academic Output SITE
op_collection_id ftnagasakiuniv
language English
description Nagasaki University (長崎大学) 博士(医学) Candida peritonitis is a crucial disease, however the optimal antifungal therapy regimen has not been clearly defined. Peritoneal fibrosis (PF) can be caused by abdominal surgery, intra-abdominal infection, and malignant diseases, and is also widely recognized as a crucial complication of long-term peritoneal dialysis. However, the influence of PF on Candida peritonitis prognosis remains unknown. Here, we evaluated the severity of Candida peritonitis within the context of PF and the efficacy of micafungin using mice. A PF mouse model was generated by intraperitoneally administering chlorhexidine gluconate. Candida peritonitis, induced by intraperitoneal inoculation of Candida albicans, was treated with a 7-day consecutive subcutaneous administration of micafungin. Candida infection caused a higher mortality rate in the PF mice compared with the control mice on day 7. Proliferative Candida invasion into the peritoneum and intra-abdominal organs was confirmed pathologically only in the PF mice. However, all mice in both groups treated with micafungin survived until day 20. Micafungin treatment tends to suppress inflammatory cytokines in the plasma 12?h after infection in both groups. Our results suggest that PF enhances early mortality in Candida peritonitis. Prompt initiation and sufficient doses of micafungin had good efficacy for Candida peritonitis, irrespective of the underlying PF. 長崎大学学位論文 学位記番号:博(医歯薬)甲第1180号 学位授与年月日:令和元年9月4日 Author: Nobuyuki Ashizawa, Taiga Miyazaki, Shinichi Abe, Takahiro Takazono, Tomomi Saijo, Yoko Obata, Shintaro Shimamura, Kazuko Yamamoto, Yoshifumi Imamura, Takehiko Koji, Tomoya Nishino, Koichi Izumikawa, Katsunori Yanagihara, Shigeru Kohno & Hiroshi Mukae Citation: Scientific Reports, 9, 9331; 2019 Nagasaki University (長崎大学), 博士(医学) (2019-09-04) doctoral thesis
format Other/Unknown Material
author 芦澤, 信之
spellingShingle 芦澤, 信之
腹膜線維症存在下でのカンジダ腹膜炎マウスモデルを用いた、腹膜線維症がカンジダ腹膜炎に及ぼす影響とミカファンギンによる治療効果の評価
author_facet 芦澤, 信之
author_sort 芦澤, 信之
title 腹膜線維症存在下でのカンジダ腹膜炎マウスモデルを用いた、腹膜線維症がカンジダ腹膜炎に及ぼす影響とミカファンギンによる治療効果の評価
title_short 腹膜線維症存在下でのカンジダ腹膜炎マウスモデルを用いた、腹膜線維症がカンジダ腹膜炎に及ぼす影響とミカファンギンによる治療効果の評価
title_full 腹膜線維症存在下でのカンジダ腹膜炎マウスモデルを用いた、腹膜線維症がカンジダ腹膜炎に及ぼす影響とミカファンギンによる治療効果の評価
title_fullStr 腹膜線維症存在下でのカンジダ腹膜炎マウスモデルを用いた、腹膜線維症がカンジダ腹膜炎に及ぼす影響とミカファンギンによる治療効果の評価
title_full_unstemmed 腹膜線維症存在下でのカンジダ腹膜炎マウスモデルを用いた、腹膜線維症がカンジダ腹膜炎に及ぼす影響とミカファンギンによる治療効果の評価
title_sort 腹膜線維症存在下でのカンジダ腹膜炎マウスモデルを用いた、腹膜線維症がカンジダ腹膜炎に及ぼす影響とミカファンギンによる治療効果の評価
publisher Springer Nature
publishDate 2019
url https://nagasaki-u.repo.nii.ac.jp/record/277/files/ISYK1180_Ashizawa.pdf
genre taiga
genre_facet taiga
op_relation 10.1038/s41598-019-45776-x
http://hdl.handle.net/10069/39479
Scientific Reports
9
9331
甲医歯薬第1180号
20452322
https://nagasaki-u.repo.nii.ac.jp/record/277/files/ISYK1180_Ashizawa.pdf
op_rights c 2019, The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
open access
_version_ 1778149935589359616

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