The influence of past endogamy and consanguinity on genetic disorders in northern Sweden
It has been widely believed that consanguineous marriage was infrequent in northern Europe. As part of ongoing studies into the population structure of northern Sweden, the Demographic DataBase of Umeå University has undertaken digitization of the parish record books of the Swedish Lutheran Church,...
Published in: | Annals of Human Genetics |
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Blackwell Publishing
2005
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Online Access: | https://doi.org/10.1046/j.1529-8817.2005.00179.x https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/The-influence-of-past-endogamy-and/991005542703107891 |
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ftmurdochunivall:oai:alma.61MUN_INST:11135877340007891 2024-09-15T18:26:03+00:00 The influence of past endogamy and consanguinity on genetic disorders in northern Sweden Bittles, A.H. Egerbladh, I. 2005 https://doi.org/10.1046/j.1529-8817.2005.00179.x https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/The-influence-of-past-endogamy-and/991005542703107891 eng eng Blackwell Publishing ispartof: Annals of Human Genetics spage 549 epage 558 issue 5 vol 69 doi:10.1046/j.1529-8817.2005.00179.x WOS:000231667100006 0003-4800 http://dx.doi.org/10.1046/j.1529-8817.2005.00179.x 991005542703107891 https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/The-influence-of-past-endogamy-and/991005542703107891 alma:61MUN_INST/bibs/991005542703107891 text Article 2005 ftmurdochunivall https://doi.org/10.1046/j.1529-8817.2005.00179.x 2024-08-15T00:52:48Z It has been widely believed that consanguineous marriage was infrequent in northern Europe. As part of ongoing studies into the population structure of northern Sweden, the Demographic DataBase of Umeå University has undertaken digitization of the parish record books of the Swedish Lutheran Church, which date back to the late 17th century. To examine the prevalence and patterns of consanguineous marriage, information from the DataBase was abstracted for the Skellefteå region during the period 1720-1899 and extended family pedigrees constructed. Of the 14,639 marriages recorded, 3,043 (20.8%) were between couples related as sixth cousins or closer. Following changes in the Swedish civil law in 1844 that removed the requirement of royal dispensation for first cousin unions, a significant increase in first cousin marriages occurred during the next two generations, even though the total population of the region grew significantly. There was also strong evidence that consanguineous marriages were favoured within particular families. The findings of the study are consistent with the patterns of single gene disorders reported in specific communities in the region, and they suggest that founder effect, drift and consanguinity all were important influences on population genetic structure in previous generations. Article in Journal/Newspaper Northern Sweden Murdoch University Research Portal Annals of Human Genetics 69 5 549 558 |
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Murdoch University Research Portal |
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English |
description |
It has been widely believed that consanguineous marriage was infrequent in northern Europe. As part of ongoing studies into the population structure of northern Sweden, the Demographic DataBase of Umeå University has undertaken digitization of the parish record books of the Swedish Lutheran Church, which date back to the late 17th century. To examine the prevalence and patterns of consanguineous marriage, information from the DataBase was abstracted for the Skellefteå region during the period 1720-1899 and extended family pedigrees constructed. Of the 14,639 marriages recorded, 3,043 (20.8%) were between couples related as sixth cousins or closer. Following changes in the Swedish civil law in 1844 that removed the requirement of royal dispensation for first cousin unions, a significant increase in first cousin marriages occurred during the next two generations, even though the total population of the region grew significantly. There was also strong evidence that consanguineous marriages were favoured within particular families. The findings of the study are consistent with the patterns of single gene disorders reported in specific communities in the region, and they suggest that founder effect, drift and consanguinity all were important influences on population genetic structure in previous generations. |
format |
Article in Journal/Newspaper |
author |
Bittles, A.H. Egerbladh, I. |
spellingShingle |
Bittles, A.H. Egerbladh, I. The influence of past endogamy and consanguinity on genetic disorders in northern Sweden |
author_facet |
Bittles, A.H. Egerbladh, I. |
author_sort |
Bittles, A.H. |
title |
The influence of past endogamy and consanguinity on genetic disorders in northern Sweden |
title_short |
The influence of past endogamy and consanguinity on genetic disorders in northern Sweden |
title_full |
The influence of past endogamy and consanguinity on genetic disorders in northern Sweden |
title_fullStr |
The influence of past endogamy and consanguinity on genetic disorders in northern Sweden |
title_full_unstemmed |
The influence of past endogamy and consanguinity on genetic disorders in northern Sweden |
title_sort |
influence of past endogamy and consanguinity on genetic disorders in northern sweden |
publisher |
Blackwell Publishing |
publishDate |
2005 |
url |
https://doi.org/10.1046/j.1529-8817.2005.00179.x https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/The-influence-of-past-endogamy-and/991005542703107891 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
ispartof: Annals of Human Genetics spage 549 epage 558 issue 5 vol 69 doi:10.1046/j.1529-8817.2005.00179.x WOS:000231667100006 0003-4800 http://dx.doi.org/10.1046/j.1529-8817.2005.00179.x 991005542703107891 https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/The-influence-of-past-endogamy-and/991005542703107891 alma:61MUN_INST/bibs/991005542703107891 |
op_doi |
https://doi.org/10.1046/j.1529-8817.2005.00179.x |
container_title |
Annals of Human Genetics |
container_volume |
69 |
container_issue |
5 |
container_start_page |
549 |
op_container_end_page |
558 |
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1810466513713364992 |