Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults
Objective: To determine the extent to which deficits in learning over 6 days are associated with β-amyloid–positive (Aβ+) and hippocampal volume in cognitively normal (CN) adults. Methods: Eighty CN older adults who had undergone PET neuroimaging to determine Aβ status (n = 42 Aβ− and 38 Aβ+), MRI t...
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ftmurdochuniv:oai:researchrepository.murdoch.edu.au:60676 2023-05-15T17:53:39+02:00 Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults Lim, Y.Y. Baker, J.E. Bruns, L. Mills, A. Fowler, C. Fripp, J. Rainey-Smith, S.R. Ames, D. Masters, C.L. Maruff, P. 2020 https://researchrepository.murdoch.edu.au/id/eprint/60676/ eng eng Lippincott Williams & Wilkins https://researchrepository.murdoch.edu.au/id/eprint/60676/ full_text_status:none © 2020 American Academy of Neurology Lim, Y.Y., Baker, J.E., Bruns, L., Mills, A., Fowler, C., Fripp, J., Rainey-Smith, S.R. <https://researchrepository.murdoch.edu.au/view/author/Rainey-Smith, Stephanie.html>, Ames, D., Masters, C.L. and Maruff, P. (2020) Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults. Neurology, 95 (18). e2577-e2585. Journal Article 2020 ftmurdochuniv 2021-05-10T22:27:02Z Objective: To determine the extent to which deficits in learning over 6 days are associated with β-amyloid–positive (Aβ+) and hippocampal volume in cognitively normal (CN) adults. Methods: Eighty CN older adults who had undergone PET neuroimaging to determine Aβ status (n = 42 Aβ− and 38 Aβ+), MRI to determine hippocampal and ventricular volume, and repeated assessment of memory were recruited from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Participants completed the Online Repeatable Cognitive Assessment–Language Learning Test (ORCA-LLT), which required they learn associations between 50 Chinese characters and their English language equivalents over 6 days. ORCA-LLT assessments were supervised on the first day and were completed remotely online for all remaining days. Results: Learning curves in the Aβ+ CN participants were significantly worse than those in matched Aβ− CN participants, with the magnitude of this difference very large (d [95% confidence interval (CI)] 2.22 [1.64–2.75], p < 0.001), and greater than differences between these groups for memory decline since their enrollment in AIBL (d [95% CI] 0.52 [0.07–0.96], p = 0.021), or memory impairment at their most recent visit. In Aβ+ CN adults, slower rates of learning were associated with smaller hippocampal and larger ventricular volumes. Conclusions: These results suggest that in CN participants, Aβ+ is associated more strongly with a deficit in learning than any aspect of memory dysfunction. Slower rates of learning in Aβ+ CN participants were associated with hippocampal volume loss. Considered together, these data suggest that the primary cognitive consequence of Aβ+ is a failure to benefit from experience when exposed to novel stimuli, even over very short periods. Article in Journal/Newspaper Orca Murdoch University: Murdoch Research Repository |
institution |
Open Polar |
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Murdoch University: Murdoch Research Repository |
op_collection_id |
ftmurdochuniv |
language |
English |
description |
Objective: To determine the extent to which deficits in learning over 6 days are associated with β-amyloid–positive (Aβ+) and hippocampal volume in cognitively normal (CN) adults. Methods: Eighty CN older adults who had undergone PET neuroimaging to determine Aβ status (n = 42 Aβ− and 38 Aβ+), MRI to determine hippocampal and ventricular volume, and repeated assessment of memory were recruited from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Participants completed the Online Repeatable Cognitive Assessment–Language Learning Test (ORCA-LLT), which required they learn associations between 50 Chinese characters and their English language equivalents over 6 days. ORCA-LLT assessments were supervised on the first day and were completed remotely online for all remaining days. Results: Learning curves in the Aβ+ CN participants were significantly worse than those in matched Aβ− CN participants, with the magnitude of this difference very large (d [95% confidence interval (CI)] 2.22 [1.64–2.75], p < 0.001), and greater than differences between these groups for memory decline since their enrollment in AIBL (d [95% CI] 0.52 [0.07–0.96], p = 0.021), or memory impairment at their most recent visit. In Aβ+ CN adults, slower rates of learning were associated with smaller hippocampal and larger ventricular volumes. Conclusions: These results suggest that in CN participants, Aβ+ is associated more strongly with a deficit in learning than any aspect of memory dysfunction. Slower rates of learning in Aβ+ CN participants were associated with hippocampal volume loss. Considered together, these data suggest that the primary cognitive consequence of Aβ+ is a failure to benefit from experience when exposed to novel stimuli, even over very short periods. |
format |
Article in Journal/Newspaper |
author |
Lim, Y.Y. Baker, J.E. Bruns, L. Mills, A. Fowler, C. Fripp, J. Rainey-Smith, S.R. Ames, D. Masters, C.L. Maruff, P. |
spellingShingle |
Lim, Y.Y. Baker, J.E. Bruns, L. Mills, A. Fowler, C. Fripp, J. Rainey-Smith, S.R. Ames, D. Masters, C.L. Maruff, P. Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults |
author_facet |
Lim, Y.Y. Baker, J.E. Bruns, L. Mills, A. Fowler, C. Fripp, J. Rainey-Smith, S.R. Ames, D. Masters, C.L. Maruff, P. |
author_sort |
Lim, Y.Y. |
title |
Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults |
title_short |
Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults |
title_full |
Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults |
title_fullStr |
Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults |
title_full_unstemmed |
Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults |
title_sort |
association of deficits in short-term learning and aβ and hippocampal volume in cognitively normal adults |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2020 |
url |
https://researchrepository.murdoch.edu.au/id/eprint/60676/ |
genre |
Orca |
genre_facet |
Orca |
op_source |
Lim, Y.Y., Baker, J.E., Bruns, L., Mills, A., Fowler, C., Fripp, J., Rainey-Smith, S.R. <https://researchrepository.murdoch.edu.au/view/author/Rainey-Smith, Stephanie.html>, Ames, D., Masters, C.L. and Maruff, P. (2020) Association of deficits in short-term learning and Aβ and hippocampal volume in cognitively normal adults. Neurology, 95 (18). e2577-e2585. |
op_relation |
https://researchrepository.murdoch.edu.au/id/eprint/60676/ full_text_status:none |
op_rights |
© 2020 American Academy of Neurology |
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1766161359989374976 |