Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia
The Antarctic continent is an environment of extreme conditions. Only few research stations exist that are occupied throughout the year. The German station Neumayer III and the French-Italian Concordia station are such research platforms and human outposts. The seasonal shifts of complete daylight (...
Published in: | Frontiers in Physiology |
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Main Authors: | , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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Ludwig-Maximilians-Universität München
2018
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Subjects: | |
Online Access: | https://epub.ub.uni-muenchen.de/64075/1/fphys-09-01647.pdf https://epub.ub.uni-muenchen.de/64075/ http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-64075-6 https://doi.org/10.3389/fphys.2018.01647 |
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Open Polar |
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Open Access LMU (Ludwig-Maximilians-University Munich) |
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ftmuenchenepub |
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English |
topic |
Medizin ddc:610 |
spellingShingle |
Medizin ddc:610 Strewe, Claudia Thieme, Detlef Dangoisse, Carole Fiedel, Barbara Berg, Floris van den Bauer, Holger Salam, Alex P. Gössmann-Lang, Petra Campolongo, Patrizia Moser, Dominique Quintens, Roel Moreels, Marjan Baatout, Sarah Kohlberg, Eberhard Schelling, Gustav Chouker, Alexander Feuerecker, Matthias Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia |
topic_facet |
Medizin ddc:610 |
description |
The Antarctic continent is an environment of extreme conditions. Only few research stations exist that are occupied throughout the year. The German station Neumayer III and the French-Italian Concordia station are such research platforms and human outposts. The seasonal shifts of complete daylight (summer) to complete darkness (winter) as well as massive changes in outside temperatures (down to -80 degrees C at Concordia) during winter result in complete confinement of the crews from the outside world. In addition, the crew at Concordia is subjected to hypobaric hypoxia of similar to 650 hPa as the station is situated at high altitude (3,233 m). We studied three expedition crews at Neumayer Ill (sea level) (n = 16) and two at Concordia (high altitude) (n = 15) to determine the effects of hypobaric hypoxia on hormonal/metabolic stress parameters [endocannabinoids (ECs), catecholamines, and glucocorticoids] and evaluated the psychological stress over a period of 11 months including winter confinement. In the Neumayer III (sea level) crew, EC and n-acylethanolamide (NAE) concentrations increased significantly already at the beginning of the deployment (p < 0.001) whereas catecholamines and cortisol remained unaffected. Over the year, ECs and NAEs stayed elevated and fluctuated before slowly decreasing till the end of the deployment. The classical stress hormones showed small increases in the last third of deployment. By contrast, at Concordia (high altitude), norepinephrine concentrations increased significantly at the beginning (p < 0.001) which was paralleled by low EC levels. Prior to the second half of deployment, norepinephrine declined constantly to end on a low plateau level, whereas then the EC concentrations increased significantly in this second period during the overwintering (p < 0.001). Psychometric data showed no significant changes in the crews at either station. These findings demonstrate that exposition of healthy humans to the physically challenging extreme environment of Antarctica (i) has a distinct modulating effect on stress responses. Additionally, (ii) acute high altitude/hypobaric hypoxia at the beginning seem to trigger catecholamine release that downregulates the EC response. These results (iii) are not associated with psychological stress. |
format |
Article in Journal/Newspaper |
author |
Strewe, Claudia Thieme, Detlef Dangoisse, Carole Fiedel, Barbara Berg, Floris van den Bauer, Holger Salam, Alex P. Gössmann-Lang, Petra Campolongo, Patrizia Moser, Dominique Quintens, Roel Moreels, Marjan Baatout, Sarah Kohlberg, Eberhard Schelling, Gustav Chouker, Alexander Feuerecker, Matthias |
author_facet |
Strewe, Claudia Thieme, Detlef Dangoisse, Carole Fiedel, Barbara Berg, Floris van den Bauer, Holger Salam, Alex P. Gössmann-Lang, Petra Campolongo, Patrizia Moser, Dominique Quintens, Roel Moreels, Marjan Baatout, Sarah Kohlberg, Eberhard Schelling, Gustav Chouker, Alexander Feuerecker, Matthias |
author_sort |
Strewe, Claudia |
title |
Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia |
title_short |
Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia |
title_full |
Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia |
title_fullStr |
Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia |
title_full_unstemmed |
Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia |
title_sort |
modulations of neuroendocrine stress responses during confinement in antarctica and the role of hypobaric hypoxia |
publisher |
Ludwig-Maximilians-Universität München |
publishDate |
2018 |
url |
https://epub.ub.uni-muenchen.de/64075/1/fphys-09-01647.pdf https://epub.ub.uni-muenchen.de/64075/ http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-64075-6 https://doi.org/10.3389/fphys.2018.01647 |
long_lat |
ENVELOPE(123.333,123.333,-75.100,-75.100) |
geographic |
Antarctic Concordia Station Neumayer The Antarctic |
geographic_facet |
Antarctic Concordia Station Neumayer The Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
Frontiers in Physiology |
op_relation |
Strewe, Claudia; Thieme, Detlef; Dangoisse, Carole; Fiedel, Barbara; Berg, Floris van den; Bauer, Holger; Salam, Alex P.; Gössmann-Lang, Petra; Campolongo, Patrizia; Moser, Dominique; Quintens, Roel; Moreels, Marjan; Baatout, Sarah; Kohlberg, Eberhard; Schelling, Gustav; Chouker, Alexander; Feuerecker, Matthias (2018): Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia. In: Frontiers in Physiology, Vol. 9, 1647 [PDF, 2MB] https://epub.ub.uni-muenchen.de/64075/1/fphys-09-01647.pdf http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-64075-6 https://epub.ub.uni-muenchen.de/64075/ doi:10.3389/fphys.2018.01647 |
op_doi |
https://doi.org/10.3389/fphys.2018.01647 |
container_title |
Frontiers in Physiology |
container_volume |
9 |
_version_ |
1766261228669239296 |
spelling |
ftmuenchenepub:oai:epub.ub.uni-muenchen.de:64075 2023-05-15T13:55:00+02:00 Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia Strewe, Claudia Thieme, Detlef Dangoisse, Carole Fiedel, Barbara Berg, Floris van den Bauer, Holger Salam, Alex P. Gössmann-Lang, Petra Campolongo, Patrizia Moser, Dominique Quintens, Roel Moreels, Marjan Baatout, Sarah Kohlberg, Eberhard Schelling, Gustav Chouker, Alexander Feuerecker, Matthias 2018-01-01 application/pdf https://epub.ub.uni-muenchen.de/64075/1/fphys-09-01647.pdf https://epub.ub.uni-muenchen.de/64075/ http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-64075-6 https://doi.org/10.3389/fphys.2018.01647 eng eng Ludwig-Maximilians-Universität München Strewe, Claudia; Thieme, Detlef; Dangoisse, Carole; Fiedel, Barbara; Berg, Floris van den; Bauer, Holger; Salam, Alex P.; Gössmann-Lang, Petra; Campolongo, Patrizia; Moser, Dominique; Quintens, Roel; Moreels, Marjan; Baatout, Sarah; Kohlberg, Eberhard; Schelling, Gustav; Chouker, Alexander; Feuerecker, Matthias (2018): Modulations of Neuroendocrine Stress Responses During Confinement in Antarctica and the Role of Hypobaric Hypoxia. In: Frontiers in Physiology, Vol. 9, 1647 [PDF, 2MB] https://epub.ub.uni-muenchen.de/64075/1/fphys-09-01647.pdf http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-64075-6 https://epub.ub.uni-muenchen.de/64075/ doi:10.3389/fphys.2018.01647 Frontiers in Physiology Medizin ddc:610 doc-type:article Zeitschriftenartikel NonPeerReviewed 2018 ftmuenchenepub https://doi.org/10.3389/fphys.2018.01647 2022-04-25T12:49:10Z The Antarctic continent is an environment of extreme conditions. Only few research stations exist that are occupied throughout the year. The German station Neumayer III and the French-Italian Concordia station are such research platforms and human outposts. The seasonal shifts of complete daylight (summer) to complete darkness (winter) as well as massive changes in outside temperatures (down to -80 degrees C at Concordia) during winter result in complete confinement of the crews from the outside world. In addition, the crew at Concordia is subjected to hypobaric hypoxia of similar to 650 hPa as the station is situated at high altitude (3,233 m). We studied three expedition crews at Neumayer Ill (sea level) (n = 16) and two at Concordia (high altitude) (n = 15) to determine the effects of hypobaric hypoxia on hormonal/metabolic stress parameters [endocannabinoids (ECs), catecholamines, and glucocorticoids] and evaluated the psychological stress over a period of 11 months including winter confinement. In the Neumayer III (sea level) crew, EC and n-acylethanolamide (NAE) concentrations increased significantly already at the beginning of the deployment (p < 0.001) whereas catecholamines and cortisol remained unaffected. Over the year, ECs and NAEs stayed elevated and fluctuated before slowly decreasing till the end of the deployment. The classical stress hormones showed small increases in the last third of deployment. By contrast, at Concordia (high altitude), norepinephrine concentrations increased significantly at the beginning (p < 0.001) which was paralleled by low EC levels. Prior to the second half of deployment, norepinephrine declined constantly to end on a low plateau level, whereas then the EC concentrations increased significantly in this second period during the overwintering (p < 0.001). Psychometric data showed no significant changes in the crews at either station. These findings demonstrate that exposition of healthy humans to the physically challenging extreme environment of Antarctica (i) has a distinct modulating effect on stress responses. Additionally, (ii) acute high altitude/hypobaric hypoxia at the beginning seem to trigger catecholamine release that downregulates the EC response. These results (iii) are not associated with psychological stress. Article in Journal/Newspaper Antarc* Antarctic Antarctica Open Access LMU (Ludwig-Maximilians-University Munich) Antarctic Concordia Station ENVELOPE(123.333,123.333,-75.100,-75.100) Neumayer The Antarctic Frontiers in Physiology 9 |