Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species
The xanthine oxidase (XO) inhibitory activity of aqueous and organic extracts of 27 selected species belonging in five genera (Fallopia, Oxyria, Persicaria, Polygonum and Rumex) of the family Polygonaceae occurring in the Carpathian Basin were tested in vitro. From different plant parts (aerial part...
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ftmtak:oai:real.mtak.hu:67178 2023-05-15T18:03:01+02:00 Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species Orbán-Gyapai, Orsolya Lajter, Ildikó Hohmann, Judit Jakab, Gusztáv Vasas, Andrea 2015 text http://real.mtak.hu/67178/ http://real.mtak.hu/67178/1/PhytotherRes_PolygonaceaeXO_2015.pdf https://doi.org/10.1002/ptr.5275 en eng Wiley http://real.mtak.hu/67178/1/PhytotherRes_PolygonaceaeXO_2015.pdf Orbán-Gyapai, Orsolya and Lajter, Ildikó and Hohmann, Judit and Jakab, Gusztáv and Vasas, Andrea (2015) Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species. Phytotherapy Research, 29. pp. 459-465. ISSN 0951-418X GE Environmental Sciences / környezettudomány RS Pharmacy and materia medica / gyógyszerészet gyógyászati eszközök Article PeerReviewed 2015 ftmtak https://doi.org/10.1002/ptr.5275 2017-11-08T23:57:12Z The xanthine oxidase (XO) inhibitory activity of aqueous and organic extracts of 27 selected species belonging in five genera (Fallopia, Oxyria, Persicaria, Polygonum and Rumex) of the family Polygonaceae occurring in the Carpathian Basin were tested in vitro. From different plant parts (aerial parts, leaves, flowers, fruits and roots), a total of 196 extracts were prepared by subsequent extraction with methanol and hot H2O and solvent–solvent partition of the MeOH extract yielding n-hexane, chloroform and 50% MeOH subextracts. It was found that the chloroform subextracts and/or the remaining 50% MeOH extracts of Fallopia species (F. bohemica, F. japonica and F. sachalinensis), Rumex species (R. acetosa, R. acetosella, R. alpinus, R. conglomeratus, R. crispus, R. hydrolapathus, R. pulcher, R. stenophyllus, R. thyrsiflorus, R. obtusifolius subsp. subalpinus, R. patientia) and Polygonum bistorta, Polygonum hydropiper, Polygonum lapathifolium and Polygonum viviparum demonstrated the highest XO inhibitory activity (>85% inhibition) at 400 µg/mL. The IC50 values of the active extracts were also determined. On the basis of the results, these plants, and especially P. hydropiper and R. acetosella, are considered worthy of activity-guided phytochemical investigations. Copyright © 2014 John Wiley & Sons, Ltd. Article in Journal/Newspaper Polygonum viviparum MTAK: REAL (Library and Information Centre of the Hungarian Academy of Sciences Phytotherapy Research 29 3 459 465 |
institution |
Open Polar |
collection |
MTAK: REAL (Library and Information Centre of the Hungarian Academy of Sciences |
op_collection_id |
ftmtak |
language |
English |
topic |
GE Environmental Sciences / környezettudomány RS Pharmacy and materia medica / gyógyszerészet gyógyászati eszközök |
spellingShingle |
GE Environmental Sciences / környezettudomány RS Pharmacy and materia medica / gyógyszerészet gyógyászati eszközök Orbán-Gyapai, Orsolya Lajter, Ildikó Hohmann, Judit Jakab, Gusztáv Vasas, Andrea Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species |
topic_facet |
GE Environmental Sciences / környezettudomány RS Pharmacy and materia medica / gyógyszerészet gyógyászati eszközök |
description |
The xanthine oxidase (XO) inhibitory activity of aqueous and organic extracts of 27 selected species belonging in five genera (Fallopia, Oxyria, Persicaria, Polygonum and Rumex) of the family Polygonaceae occurring in the Carpathian Basin were tested in vitro. From different plant parts (aerial parts, leaves, flowers, fruits and roots), a total of 196 extracts were prepared by subsequent extraction with methanol and hot H2O and solvent–solvent partition of the MeOH extract yielding n-hexane, chloroform and 50% MeOH subextracts. It was found that the chloroform subextracts and/or the remaining 50% MeOH extracts of Fallopia species (F. bohemica, F. japonica and F. sachalinensis), Rumex species (R. acetosa, R. acetosella, R. alpinus, R. conglomeratus, R. crispus, R. hydrolapathus, R. pulcher, R. stenophyllus, R. thyrsiflorus, R. obtusifolius subsp. subalpinus, R. patientia) and Polygonum bistorta, Polygonum hydropiper, Polygonum lapathifolium and Polygonum viviparum demonstrated the highest XO inhibitory activity (>85% inhibition) at 400 µg/mL. The IC50 values of the active extracts were also determined. On the basis of the results, these plants, and especially P. hydropiper and R. acetosella, are considered worthy of activity-guided phytochemical investigations. Copyright © 2014 John Wiley & Sons, Ltd. |
format |
Article in Journal/Newspaper |
author |
Orbán-Gyapai, Orsolya Lajter, Ildikó Hohmann, Judit Jakab, Gusztáv Vasas, Andrea |
author_facet |
Orbán-Gyapai, Orsolya Lajter, Ildikó Hohmann, Judit Jakab, Gusztáv Vasas, Andrea |
author_sort |
Orbán-Gyapai, Orsolya |
title |
Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species |
title_short |
Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species |
title_full |
Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species |
title_fullStr |
Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species |
title_full_unstemmed |
Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species |
title_sort |
xanthine oxidase inhibitory activity of extracts prepared from polygonaceae species |
publisher |
Wiley |
publishDate |
2015 |
url |
http://real.mtak.hu/67178/ http://real.mtak.hu/67178/1/PhytotherRes_PolygonaceaeXO_2015.pdf https://doi.org/10.1002/ptr.5275 |
genre |
Polygonum viviparum |
genre_facet |
Polygonum viviparum |
op_relation |
http://real.mtak.hu/67178/1/PhytotherRes_PolygonaceaeXO_2015.pdf Orbán-Gyapai, Orsolya and Lajter, Ildikó and Hohmann, Judit and Jakab, Gusztáv and Vasas, Andrea (2015) Xanthine Oxidase Inhibitory Activity of Extracts Prepared from Polygonaceae Species. Phytotherapy Research, 29. pp. 459-465. ISSN 0951-418X |
op_doi |
https://doi.org/10.1002/ptr.5275 |
container_title |
Phytotherapy Research |
container_volume |
29 |
container_issue |
3 |
container_start_page |
459 |
op_container_end_page |
465 |
_version_ |
1766173726374625280 |