Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections
The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared wi...
Published in: | Epidemiology and Infection |
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Online Access: | https://research.monash.edu/en/publications/6bbf2a45-f575-4ee4-82e0-67459b72ae24 https://doi.org/10.1017/S095026881900102X https://researchmgt.monash.edu/ws/files/320131683/283007456_oa.pdf http://www.scopus.com/inward/record.url?scp=85070820729&partnerID=8YFLogxK |
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ftmonashunicris:oai:monash.edu:publications/6bbf2a45-f575-4ee4-82e0-67459b72ae24 2023-05-15T15:34:26+02:00 Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections Komadina, N. Sullivan, S.G. Kedzierska, K. Quiñones-Parra, S.M. Leder, K. McVernon, J. 2019 application/pdf https://research.monash.edu/en/publications/6bbf2a45-f575-4ee4-82e0-67459b72ae24 https://doi.org/10.1017/S095026881900102X https://researchmgt.monash.edu/ws/files/320131683/283007456_oa.pdf http://www.scopus.com/inward/record.url?scp=85070820729&partnerID=8YFLogxK eng eng info:eu-repo/semantics/openAccess Komadina , N , Sullivan , S G , Kedzierska , K , Quiñones-Parra , S M , Leder , K & McVernon , J 2019 , ' Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections ' , Epidemiology and Infection , vol. 147 , e213 . https://doi.org/10.1017/S095026881900102X Avian flu H5N1 H7N9 Immunogenic peptides Influenza A article 2019 ftmonashunicris https://doi.org/10.1017/S095026881900102X 2023-01-20T07:51:43Z The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared with H7N9 virus (63 years). Population susceptibility to infection with seasonal influenza is understood to be influenced by cross-reactive CD8+ T cells directed towards immunogenic peptides derived from internal viral proteins which may provide some level of protection against further influenza infection. Prior exposure to seasonal influenza peptides may influence the age-related infection patterns observed for H5N1 and H7N9 viruses. A comparison of relatedness of immunogenic peptides between historical human strains and the two avian emerged viruses was undertaken for a possible explanation in the differences in age incidence observed. There appeared to be some relationship between past exposure to related peptides and the lower number of H5N1 virus cases in older populations, however the relationship between prior exposure and older populations among H7N9 virus patients was less clear. Article in Journal/Newspaper Avian flu Monash University Research Portal Epidemiology and Infection 147 |
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Open Polar |
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Monash University Research Portal |
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ftmonashunicris |
language |
English |
topic |
Avian flu H5N1 H7N9 Immunogenic peptides Influenza A |
spellingShingle |
Avian flu H5N1 H7N9 Immunogenic peptides Influenza A Komadina, N. Sullivan, S.G. Kedzierska, K. Quiñones-Parra, S.M. Leder, K. McVernon, J. Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections |
topic_facet |
Avian flu H5N1 H7N9 Immunogenic peptides Influenza A |
description |
The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared with H7N9 virus (63 years). Population susceptibility to infection with seasonal influenza is understood to be influenced by cross-reactive CD8+ T cells directed towards immunogenic peptides derived from internal viral proteins which may provide some level of protection against further influenza infection. Prior exposure to seasonal influenza peptides may influence the age-related infection patterns observed for H5N1 and H7N9 viruses. A comparison of relatedness of immunogenic peptides between historical human strains and the two avian emerged viruses was undertaken for a possible explanation in the differences in age incidence observed. There appeared to be some relationship between past exposure to related peptides and the lower number of H5N1 virus cases in older populations, however the relationship between prior exposure and older populations among H7N9 virus patients was less clear. |
format |
Article in Journal/Newspaper |
author |
Komadina, N. Sullivan, S.G. Kedzierska, K. Quiñones-Parra, S.M. Leder, K. McVernon, J. |
author_facet |
Komadina, N. Sullivan, S.G. Kedzierska, K. Quiñones-Parra, S.M. Leder, K. McVernon, J. |
author_sort |
Komadina, N. |
title |
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections |
title_short |
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections |
title_full |
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections |
title_fullStr |
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections |
title_full_unstemmed |
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections |
title_sort |
prior exposure to immunogenic peptides found in human influenza a viruses may influence the age distribution of cases with avian influenza h5n1 and h7n9 virus infections |
publishDate |
2019 |
url |
https://research.monash.edu/en/publications/6bbf2a45-f575-4ee4-82e0-67459b72ae24 https://doi.org/10.1017/S095026881900102X https://researchmgt.monash.edu/ws/files/320131683/283007456_oa.pdf http://www.scopus.com/inward/record.url?scp=85070820729&partnerID=8YFLogxK |
genre |
Avian flu |
genre_facet |
Avian flu |
op_source |
Komadina , N , Sullivan , S G , Kedzierska , K , Quiñones-Parra , S M , Leder , K & McVernon , J 2019 , ' Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections ' , Epidemiology and Infection , vol. 147 , e213 . https://doi.org/10.1017/S095026881900102X |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1017/S095026881900102X |
container_title |
Epidemiology and Infection |
container_volume |
147 |
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1766364831837847552 |