An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment
Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise...
Published in: | International Journal of Circumpolar Health |
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Mittuniversitetet, Institutionen för hälsovetenskap
2021
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Online Access: | http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-41719 https://doi.org/10.1080/22423982.2021.1897213 |
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ftmittuniv:oai:DiVA.org:miun-41719 2023-05-15T15:55:25+02:00 An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment Eklund, L. Schagatay, F. Tufvesson, E. Sjöström, R. Söderström, L. Hanstock, Helen Sandström, T. Stenfors, N. 2021 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-41719 https://doi.org/10.1080/22423982.2021.1897213 eng eng Mittuniversitetet, Institutionen för hälsovetenskap International Journal of Circumpolar Health, 1239-9736, 2021, 80:1, http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-41719 doi:10.1080/22423982.2021.1897213 PMID 33685367 ISI:000626745700001 Scopus 2-s2.0-85102302227 info:eu-repo/semantics/openAccess asthma Cold temperature environmental chamber healthy physical activity respiratory symptoms Clinical Medicine Klinisk medicin Article in journal info:eu-repo/semantics/article text 2021 ftmittuniv https://doi.org/10.1080/22423982.2021.1897213 2023-04-07T06:11:46Z Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero temperature in healthy individuals. Thirty-one healthy subjects underwent whole-body exposures for 50 minutes on two occasions in an environmental chamber with intermittent moderate-intensity exercise in +10 °C and -10 °C. Lung function, plasma/urine CC16 , and symptoms were investigated before and after exposures. Compared to baseline, exercise in -10 °C decreased FEV1 (p=0.002), FEV1/FVC (p<0.001), and increased R20Hz (p=0.016), with no differences between exposures. Reactance increased after +10 °C (p=0.005), which differed (p=0.042) from a blunted response after exercise in -10 °C. Plasma CC16 increased significantly within exposures, without differences between exposures. Exercise in -10 °C elicited more intense symptoms from the upper airways, compared to +10 °C. Symptoms from the lower airways were few and mild. Short-duration moderate-intensity exercise in -10 °C induces mild symptoms from the lower airways, no lung function decrements or enhanced leakage of biomarkers of airway epithelial injury, and no peripheral bronchodilatation, compared to exercise in +10 °C. Article in Journal/Newspaper Circumpolar Health International Journal of Circumpolar Health Mid Sweden University: Publications (DiVA) International Journal of Circumpolar Health 80 1 1897213 |
institution |
Open Polar |
collection |
Mid Sweden University: Publications (DiVA) |
op_collection_id |
ftmittuniv |
language |
English |
topic |
asthma Cold temperature environmental chamber healthy physical activity respiratory symptoms Clinical Medicine Klinisk medicin |
spellingShingle |
asthma Cold temperature environmental chamber healthy physical activity respiratory symptoms Clinical Medicine Klinisk medicin Eklund, L. Schagatay, F. Tufvesson, E. Sjöström, R. Söderström, L. Hanstock, Helen Sandström, T. Stenfors, N. An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
topic_facet |
asthma Cold temperature environmental chamber healthy physical activity respiratory symptoms Clinical Medicine Klinisk medicin |
description |
Exposure to a cold climate is associated with an increased morbidity and mortality, but the specific mechanisms are largely unknown. People with cardiopulmonary disease and winter endurance athletes are particularly vulnerable. This study aimed to map multiple domains of airway responses to exercise in subzero temperature in healthy individuals. Thirty-one healthy subjects underwent whole-body exposures for 50 minutes on two occasions in an environmental chamber with intermittent moderate-intensity exercise in +10 °C and -10 °C. Lung function, plasma/urine CC16 , and symptoms were investigated before and after exposures. Compared to baseline, exercise in -10 °C decreased FEV1 (p=0.002), FEV1/FVC (p<0.001), and increased R20Hz (p=0.016), with no differences between exposures. Reactance increased after +10 °C (p=0.005), which differed (p=0.042) from a blunted response after exercise in -10 °C. Plasma CC16 increased significantly within exposures, without differences between exposures. Exercise in -10 °C elicited more intense symptoms from the upper airways, compared to +10 °C. Symptoms from the lower airways were few and mild. Short-duration moderate-intensity exercise in -10 °C induces mild symptoms from the lower airways, no lung function decrements or enhanced leakage of biomarkers of airway epithelial injury, and no peripheral bronchodilatation, compared to exercise in +10 °C. |
format |
Article in Journal/Newspaper |
author |
Eklund, L. Schagatay, F. Tufvesson, E. Sjöström, R. Söderström, L. Hanstock, Helen Sandström, T. Stenfors, N. |
author_facet |
Eklund, L. Schagatay, F. Tufvesson, E. Sjöström, R. Söderström, L. Hanstock, Helen Sandström, T. Stenfors, N. |
author_sort |
Eklund, L. |
title |
An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
title_short |
An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
title_full |
An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
title_fullStr |
An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
title_full_unstemmed |
An experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
title_sort |
experimental exposure study revealing composite airway effects of physical exercise in a subzero environment |
publisher |
Mittuniversitetet, Institutionen för hälsovetenskap |
publishDate |
2021 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-41719 https://doi.org/10.1080/22423982.2021.1897213 |
genre |
Circumpolar Health International Journal of Circumpolar Health |
genre_facet |
Circumpolar Health International Journal of Circumpolar Health |
op_relation |
International Journal of Circumpolar Health, 1239-9736, 2021, 80:1, http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-41719 doi:10.1080/22423982.2021.1897213 PMID 33685367 ISI:000626745700001 Scopus 2-s2.0-85102302227 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1080/22423982.2021.1897213 |
container_title |
International Journal of Circumpolar Health |
container_volume |
80 |
container_issue |
1 |
container_start_page |
1897213 |
_version_ |
1766390916227006464 |