Multiple Measures of Adiposity Are Associated with Mean Leukocyte Telomere Length in the Northern Finland Birth Cohort 1966
Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth me...
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Mittuniversitetet, Avdelningen för psykologi
2014
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ftmittuniv:oai:DiVA.org:miun-22586 2023-05-15T17:42:33+02:00 Multiple Measures of Adiposity Are Associated with Mean Leukocyte Telomere Length in the Northern Finland Birth Cohort 1966 Buxton, Jessica L. Das, Shikta Rodriguez, Alina Kaakinen, Marika Alves, Alexessander Couto Sebert, Sylvain Millwood, Iona Y. Laitinen, Jaana O'Reilly, Paul F. Jarvelin, Marjo-Riitta Blakemore, Alexandra I. F. 2014 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-22586 https://doi.org/10.1371/journal.pone.0099133 eng eng Mittuniversitetet, Avdelningen för psykologi Univ London Imperial Coll Sci Technol & Med, Dept Med, Sect Investigat Med, London, England Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Ctr Environm & Hlth, MRC,Publ Hlth England,Dept Epidemiol & Biostat, London, England Univ Oulu, Inst Hlth Sci, Oulu, Finland Univ Oxford, Clin Trial Serv Unit, Oxford, England Finnish Inst Occupat Hlth, Helsinki, Finland Kings Coll London, Inst Psychiat, MRC, Social Genet & Dev Psychiat Ctr, London, England Natl Inst Hlth & Welf, Dept Children & Young People & Families, Oulu, Finland PLOS ONE, 2014, 9:6, s. Art. no. e99133- http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-22586 doi:10.1371/journal.pone.0099133 ISI:000338631000052 Scopus 2-s2.0-84903388475 info:eu-repo/semantics/openAccess Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Article in journal info:eu-repo/semantics/article text 2014 ftmittuniv https://doi.org/10.1371/journal.pone.0099133 2023-04-07T06:11:51Z Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing. Article in Journal/Newspaper Northern Finland Mid Sweden University: Publications (DiVA) PLoS ONE 9 6 e99133 |
institution |
Open Polar |
collection |
Mid Sweden University: Publications (DiVA) |
op_collection_id |
ftmittuniv |
language |
English |
topic |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
spellingShingle |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi Buxton, Jessica L. Das, Shikta Rodriguez, Alina Kaakinen, Marika Alves, Alexessander Couto Sebert, Sylvain Millwood, Iona Y. Laitinen, Jaana O'Reilly, Paul F. Jarvelin, Marjo-Riitta Blakemore, Alexandra I. F. Multiple Measures of Adiposity Are Associated with Mean Leukocyte Telomere Length in the Northern Finland Birth Cohort 1966 |
topic_facet |
Public Health Global Health Social Medicine and Epidemiology Folkhälsovetenskap global hälsa socialmedicin och epidemiologi |
description |
Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing. |
format |
Article in Journal/Newspaper |
author |
Buxton, Jessica L. Das, Shikta Rodriguez, Alina Kaakinen, Marika Alves, Alexessander Couto Sebert, Sylvain Millwood, Iona Y. Laitinen, Jaana O'Reilly, Paul F. Jarvelin, Marjo-Riitta Blakemore, Alexandra I. F. |
author_facet |
Buxton, Jessica L. Das, Shikta Rodriguez, Alina Kaakinen, Marika Alves, Alexessander Couto Sebert, Sylvain Millwood, Iona Y. Laitinen, Jaana O'Reilly, Paul F. Jarvelin, Marjo-Riitta Blakemore, Alexandra I. F. |
author_sort |
Buxton, Jessica L. |
title |
Multiple Measures of Adiposity Are Associated with Mean Leukocyte Telomere Length in the Northern Finland Birth Cohort 1966 |
title_short |
Multiple Measures of Adiposity Are Associated with Mean Leukocyte Telomere Length in the Northern Finland Birth Cohort 1966 |
title_full |
Multiple Measures of Adiposity Are Associated with Mean Leukocyte Telomere Length in the Northern Finland Birth Cohort 1966 |
title_fullStr |
Multiple Measures of Adiposity Are Associated with Mean Leukocyte Telomere Length in the Northern Finland Birth Cohort 1966 |
title_full_unstemmed |
Multiple Measures of Adiposity Are Associated with Mean Leukocyte Telomere Length in the Northern Finland Birth Cohort 1966 |
title_sort |
multiple measures of adiposity are associated with mean leukocyte telomere length in the northern finland birth cohort 1966 |
publisher |
Mittuniversitetet, Avdelningen för psykologi |
publishDate |
2014 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-22586 https://doi.org/10.1371/journal.pone.0099133 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
PLOS ONE, 2014, 9:6, s. Art. no. e99133- http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-22586 doi:10.1371/journal.pone.0099133 ISI:000338631000052 Scopus 2-s2.0-84903388475 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0099133 |
container_title |
PLoS ONE |
container_volume |
9 |
container_issue |
6 |
container_start_page |
e99133 |
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1766144430194032640 |