Placental Size Is Associated with Mental Health in Children and Adolescents
Background: The role of the placenta in fetal programming has been recognized as a highly significant, yet often neglected area of study. We investigated placental size in relation to psychopathology, in particular attention deficit hyperactivity disorder (ADHD) symptoms, in children at 8 years of a...
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Mittuniversitetet, Institutionen för samhällsvetenskap
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ftmittuniv:oai:DiVA.org:miun-17060 2023-05-15T17:42:44+02:00 Placental Size Is Associated with Mental Health in Children and Adolescents Khalife, Natasha Glover, Vivette Hartikainen, Anna-Liisa Taanila, Anja Ebeling, Hanna Jarvelin, Marjo-Riitta Rodriguez, Alina 2012 application/pdf http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-17060 https://doi.org/10.1371/journal.pone.0040534 eng eng Mittuniversitetet, Institutionen för samhällsvetenskap Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, London, England Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, London, England Univ Oulu, Inst Clin Med, Oulu, Finland Univ Oulu, Inst Hlth Sci, Oulu, Finland Oulu Univ Hosp, Clin Child Psychiat, Oulu, Finland PLOS ONE, 2012, 7:7, s. Art. no. e40534- http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-17060 doi:10.1371/journal.pone.0040534 ISI:000306354700058 Scopus 2-s2.0-84863633083 info:eu-repo/semantics/openAccess adolescent article attention deficit disorder birth weight child child behavior child health cohort analysis controlled study demography disease association female Finland gestational age human major clinical study male mental disease mental health placenta weight prospective study school child Psychiatry Psykiatri Pediatrics Pediatrik Article in journal info:eu-repo/semantics/article text 2012 ftmittuniv https://doi.org/10.1371/journal.pone.0040534 2023-04-07T06:11:51Z Background: The role of the placenta in fetal programming has been recognized as a highly significant, yet often neglected area of study. We investigated placental size in relation to psychopathology, in particular attention deficit hyperactivity disorder (ADHD) symptoms, in children at 8 years of age, and later as adolescents at 16 years. Methodology/Principal Findings: Prospective data were obtained from The Northern Finland Birth Cohort (NFBC) 1986. Placental weight, surface area and birth weight were measured according to standard procedures, within 30 minutes after birth. ADHD symptoms, probable psychiatric disturbance, antisocial disorder and neurotic disorder were assessed at 8 years (n = 8101), and ADHD symptoms were assessed again at 16 years (n = 6607), by teachers and parents respectively. We used logistic regression analyses to investigate the association between placental size and mental health outcomes, and controlled for gestational age, birth weight, socio-demographic factors and medical factors, during gestation. There were significant positive associations between placental size (weight, surface area and placental-to-birth-weight ratio) and mental health problems in boys at 8 and 16 years of age. Increased placental weight was linked with overall probable psychiatric disturbance (at 8y, OR = 1.14 [95% CI = 1.04-1.25]), antisocial behavior (at 8 y, OR = 1.14 [95% CI = 1.03-1.27]) and ADHD symptoms (inattention-hyperactivity at 16y, OR = 1.19 [95% CI = 1.02-1.38]). No significant associations were detected among girls. Conclusions/Significance: Compensatory placental growth may occur in response to prenatal insults. Such overgrowth may affect fetal development, including brain development, and ultimately contribute to psychopathology. Article in Journal/Newspaper Northern Finland Mid Sweden University: Publications (DiVA) PLoS ONE 7 7 e40534 |
institution |
Open Polar |
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Mid Sweden University: Publications (DiVA) |
op_collection_id |
ftmittuniv |
language |
English |
topic |
adolescent article attention deficit disorder birth weight child child behavior child health cohort analysis controlled study demography disease association female Finland gestational age human major clinical study male mental disease mental health placenta weight prospective study school child Psychiatry Psykiatri Pediatrics Pediatrik |
spellingShingle |
adolescent article attention deficit disorder birth weight child child behavior child health cohort analysis controlled study demography disease association female Finland gestational age human major clinical study male mental disease mental health placenta weight prospective study school child Psychiatry Psykiatri Pediatrics Pediatrik Khalife, Natasha Glover, Vivette Hartikainen, Anna-Liisa Taanila, Anja Ebeling, Hanna Jarvelin, Marjo-Riitta Rodriguez, Alina Placental Size Is Associated with Mental Health in Children and Adolescents |
topic_facet |
adolescent article attention deficit disorder birth weight child child behavior child health cohort analysis controlled study demography disease association female Finland gestational age human major clinical study male mental disease mental health placenta weight prospective study school child Psychiatry Psykiatri Pediatrics Pediatrik |
description |
Background: The role of the placenta in fetal programming has been recognized as a highly significant, yet often neglected area of study. We investigated placental size in relation to psychopathology, in particular attention deficit hyperactivity disorder (ADHD) symptoms, in children at 8 years of age, and later as adolescents at 16 years. Methodology/Principal Findings: Prospective data were obtained from The Northern Finland Birth Cohort (NFBC) 1986. Placental weight, surface area and birth weight were measured according to standard procedures, within 30 minutes after birth. ADHD symptoms, probable psychiatric disturbance, antisocial disorder and neurotic disorder were assessed at 8 years (n = 8101), and ADHD symptoms were assessed again at 16 years (n = 6607), by teachers and parents respectively. We used logistic regression analyses to investigate the association between placental size and mental health outcomes, and controlled for gestational age, birth weight, socio-demographic factors and medical factors, during gestation. There were significant positive associations between placental size (weight, surface area and placental-to-birth-weight ratio) and mental health problems in boys at 8 and 16 years of age. Increased placental weight was linked with overall probable psychiatric disturbance (at 8y, OR = 1.14 [95% CI = 1.04-1.25]), antisocial behavior (at 8 y, OR = 1.14 [95% CI = 1.03-1.27]) and ADHD symptoms (inattention-hyperactivity at 16y, OR = 1.19 [95% CI = 1.02-1.38]). No significant associations were detected among girls. Conclusions/Significance: Compensatory placental growth may occur in response to prenatal insults. Such overgrowth may affect fetal development, including brain development, and ultimately contribute to psychopathology. |
format |
Article in Journal/Newspaper |
author |
Khalife, Natasha Glover, Vivette Hartikainen, Anna-Liisa Taanila, Anja Ebeling, Hanna Jarvelin, Marjo-Riitta Rodriguez, Alina |
author_facet |
Khalife, Natasha Glover, Vivette Hartikainen, Anna-Liisa Taanila, Anja Ebeling, Hanna Jarvelin, Marjo-Riitta Rodriguez, Alina |
author_sort |
Khalife, Natasha |
title |
Placental Size Is Associated with Mental Health in Children and Adolescents |
title_short |
Placental Size Is Associated with Mental Health in Children and Adolescents |
title_full |
Placental Size Is Associated with Mental Health in Children and Adolescents |
title_fullStr |
Placental Size Is Associated with Mental Health in Children and Adolescents |
title_full_unstemmed |
Placental Size Is Associated with Mental Health in Children and Adolescents |
title_sort |
placental size is associated with mental health in children and adolescents |
publisher |
Mittuniversitetet, Institutionen för samhällsvetenskap |
publishDate |
2012 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-17060 https://doi.org/10.1371/journal.pone.0040534 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
PLOS ONE, 2012, 7:7, s. Art. no. e40534- http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-17060 doi:10.1371/journal.pone.0040534 ISI:000306354700058 Scopus 2-s2.0-84863633083 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0040534 |
container_title |
PLoS ONE |
container_volume |
7 |
container_issue |
7 |
container_start_page |
e40534 |
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1766144641029111808 |