7.345 Survival in Extreme Conditions: The Bacterial Stress Response, Fall 2010

• Main Author: Peterson, Celeste
• Language: English
• Published: 2023
• Subjects: bacteria; microbes; signal transduction pathways; cellular response; model systems; Escherichia coli; Bacillus subtilis; oxidative stress; starvation; heat shock; dormant state; microbial stress response; bacterial genetics; microbiology; sporulation; sRNAs; histidine kinases; response regulators; mRNAs; RpoS; small molecules; efflux pumps; Pseudomonas aeruginosa; 260503; Arctic; Tundra
• Online Access: https://hdl.handle.net/1721.1/148322

Bacteria survive in almost all environments on Earth, including some considered extremely harsh. From the steaming hot springs of Yellowstone to the frozen tundra of the arctic to the barren deserts of Chile, microbes have been found thriving. Their tenacity to survive in such extreme and varied conditions allows them to play fundamental roles in global nutrient cycling. Microbes also cause a wide range of human diseases and can survive inhospitable conditions found in the human body. In this course, we will examine the molecular systems that bacteria use to adapt to changes in their environment. We will consider stresses commonly encountered, such as starvation, oxidative stress and heat shock, and also discuss how the adaptive responses affect the evolution of the bacteria. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.