Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir
Influenza A virus (IAV) has been associated with multiple unusual mortality events (UMEs) in North Atlantic pinnipeds, frequently attributed to spillover of virus from wild-bird reservoirs. To determine if endemic infection persists outside of UMEs, we undertook a multiyear investigation of IAV in h...
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ftmit:oai:dspace.mit.edu:1721.1/106881 2023-06-11T04:14:32+02:00 Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir Keogh, Mandy Moxley, Jerry Josephson, Elizabeth Lidgard, Damian Bogomolni, Andrea Levin, Milton Lang, Shelley Hammill, Michael Bowen, Don Johnston, David W Romano, Tracy Waring, Gordon Puryear, Wendy Hill, Nichola Davis, Kimberly Ryan Bandoro, Christopher Runstadler, Jonathan Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Division of Comparative Medicine Puryear, Wendy Hill, Nichola Davis, Kimberly Ryan Bandoro, Christopher Runstadler, Jonathan 2016-04 application/pdf http://hdl.handle.net/1721.1/106881 en_US eng Springer http://dx.doi.org/10.1038/emi.2016.77 Emerging Microbes & Infections 2222-1751 http://hdl.handle.net/1721.1/106881 Puryear, Wendy Blay et al. “Prevalence of Influenza A Virus in Live-Captured North Atlantic Gray Seals: A Possible Wild Reservoir.” Emerging Microbes & Infections 5.8 (2016): e81. orcid:0000-0003-3213-6693 orcid:0000-0002-5367-3298 orcid:0000-0002-7615-4220 orcid:0000-0002-6747-7765 Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ Nature Article http://purl.org/eprint/type/JournalArticle 2016 ftmit https://doi.org/10.1038/emi.2016.77 2023-05-29T08:25:26Z Influenza A virus (IAV) has been associated with multiple unusual mortality events (UMEs) in North Atlantic pinnipeds, frequently attributed to spillover of virus from wild-bird reservoirs. To determine if endemic infection persists outside of UMEs, we undertook a multiyear investigation of IAV in healthy, live-captured Northwest Atlantic gray seals (Halichoerus grypus). From 2013 to 2015, we sampled 345 pups and 57 adults from Cape Cod, MA, USA and Nova Scotia, Canada consistently detecting IAV infection across all groups. There was an overall viral prevalence of 9.0% (95% confidence interval (CI): 6.4%–12.5%) in weaned pups and 5.3% (CI: 1.2%–14.6%) in adults, with seroprevalences of 19.3% (CI: 15.0%–24.5%) and 50% (CI: 33.7%–66.4%), respectively. Positive sera showed a broad reactivity to diverse influenza subtypes. IAV status did not correlate with measures of animal health nor impact animal movement or foraging. This study demonstrated that Northwest Atlantic gray seals are both permissive to and tolerant of diverse IAV, possibly representing an endemically infected wild reservoir population. National Institute of Allergy and Infectious Diseases (U.S.) Massachusetts Institute of Technology. Sea Grant College Program (Project 2013-DOH- 45-LEV) Natural Sciences and Engineering Research Council of Canada United States. National Marine Fisheries Service (Grants NMFS #17670-01, NMFS #10080-95 and FWS #53514-13003) National Institute of Allergy and Infectious Diseases (U.S). Centers of Excellence for Influenza Research and Surveillance Program (Grant HHSN272201400008C) Article in Journal/Newspaper North Atlantic Northwest Atlantic DSpace@MIT (Massachusetts Institute of Technology) Canada Emerging Microbes & Infections 5 1 1 9 |
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DSpace@MIT (Massachusetts Institute of Technology) |
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ftmit |
language |
English |
description |
Influenza A virus (IAV) has been associated with multiple unusual mortality events (UMEs) in North Atlantic pinnipeds, frequently attributed to spillover of virus from wild-bird reservoirs. To determine if endemic infection persists outside of UMEs, we undertook a multiyear investigation of IAV in healthy, live-captured Northwest Atlantic gray seals (Halichoerus grypus). From 2013 to 2015, we sampled 345 pups and 57 adults from Cape Cod, MA, USA and Nova Scotia, Canada consistently detecting IAV infection across all groups. There was an overall viral prevalence of 9.0% (95% confidence interval (CI): 6.4%–12.5%) in weaned pups and 5.3% (CI: 1.2%–14.6%) in adults, with seroprevalences of 19.3% (CI: 15.0%–24.5%) and 50% (CI: 33.7%–66.4%), respectively. Positive sera showed a broad reactivity to diverse influenza subtypes. IAV status did not correlate with measures of animal health nor impact animal movement or foraging. This study demonstrated that Northwest Atlantic gray seals are both permissive to and tolerant of diverse IAV, possibly representing an endemically infected wild reservoir population. National Institute of Allergy and Infectious Diseases (U.S.) Massachusetts Institute of Technology. Sea Grant College Program (Project 2013-DOH- 45-LEV) Natural Sciences and Engineering Research Council of Canada United States. National Marine Fisheries Service (Grants NMFS #17670-01, NMFS #10080-95 and FWS #53514-13003) National Institute of Allergy and Infectious Diseases (U.S). Centers of Excellence for Influenza Research and Surveillance Program (Grant HHSN272201400008C) |
author2 |
Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Division of Comparative Medicine Puryear, Wendy Hill, Nichola Davis, Kimberly Ryan Bandoro, Christopher Runstadler, Jonathan |
format |
Article in Journal/Newspaper |
author |
Keogh, Mandy Moxley, Jerry Josephson, Elizabeth Lidgard, Damian Bogomolni, Andrea Levin, Milton Lang, Shelley Hammill, Michael Bowen, Don Johnston, David W Romano, Tracy Waring, Gordon Puryear, Wendy Hill, Nichola Davis, Kimberly Ryan Bandoro, Christopher Runstadler, Jonathan |
spellingShingle |
Keogh, Mandy Moxley, Jerry Josephson, Elizabeth Lidgard, Damian Bogomolni, Andrea Levin, Milton Lang, Shelley Hammill, Michael Bowen, Don Johnston, David W Romano, Tracy Waring, Gordon Puryear, Wendy Hill, Nichola Davis, Kimberly Ryan Bandoro, Christopher Runstadler, Jonathan Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir |
author_facet |
Keogh, Mandy Moxley, Jerry Josephson, Elizabeth Lidgard, Damian Bogomolni, Andrea Levin, Milton Lang, Shelley Hammill, Michael Bowen, Don Johnston, David W Romano, Tracy Waring, Gordon Puryear, Wendy Hill, Nichola Davis, Kimberly Ryan Bandoro, Christopher Runstadler, Jonathan |
author_sort |
Keogh, Mandy |
title |
Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir |
title_short |
Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir |
title_full |
Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir |
title_fullStr |
Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir |
title_full_unstemmed |
Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir |
title_sort |
prevalence of influenza a virus in live-captured north atlantic gray seals: a possible wild reservoir |
publisher |
Springer |
publishDate |
2016 |
url |
http://hdl.handle.net/1721.1/106881 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
North Atlantic Northwest Atlantic |
genre_facet |
North Atlantic Northwest Atlantic |
op_source |
Nature |
op_relation |
http://dx.doi.org/10.1038/emi.2016.77 Emerging Microbes & Infections 2222-1751 http://hdl.handle.net/1721.1/106881 Puryear, Wendy Blay et al. “Prevalence of Influenza A Virus in Live-Captured North Atlantic Gray Seals: A Possible Wild Reservoir.” Emerging Microbes & Infections 5.8 (2016): e81. orcid:0000-0003-3213-6693 orcid:0000-0002-5367-3298 orcid:0000-0002-7615-4220 orcid:0000-0002-6747-7765 |
op_rights |
Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1038/emi.2016.77 |
container_title |
Emerging Microbes & Infections |
container_volume |
5 |
container_issue |
1 |
container_start_page |
1 |
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9 |
_version_ |
1768392611588997120 |