Multiple FGF4 retrocopies recently derived within canids
Two transcribed retrocopies of the fibroblast growth factor 4 (FGF4) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebral...
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ftmichigantuniv:oai:digitalcommons.mtu.edu:michigantech-p-3663 2023-05-15T15:50:20+02:00 Multiple FGF4 retrocopies recently derived within canids Batcher, Kevin Dickinson, Peter Maciejczyk, Kimberly Brzeski, Kristin Rasouliha, Sheida Hadji Letko, Anna Drögemüller, Cord Leeb, Tosso Bannasch, Danika 2020-08-01T07:00:00Z application/pdf https://digitalcommons.mtu.edu/michigantech-p/2673 https://digitalcommons.mtu.edu/cgi/viewcontent.cgi?article=3663&context=michigantech-p unknown Digital Commons @ Michigan Tech https://digitalcommons.mtu.edu/michigantech-p/2673 https://digitalcommons.mtu.edu/cgi/viewcontent.cgi?article=3663&context=michigantech-p http://creativecommons.org/licenses/by/4.0/ CC-BY Michigan Tech Publications Canis lupus familiaris Duplication FGF4 Pseudogene Retrocopy Retrogene Retrotransposition College of Forest Resources and Environmental Science Forest Sciences text 2020 ftmichigantuniv 2022-01-23T10:42:38Z Two transcribed retrocopies of the fibroblast growth factor 4 (FGF4) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebral disc disease (IVDD). In this study, whole-genome sequencing data were queried to identify other FGF4 retrocopies that could be contributing to phenotypic diversity in canids. Additionally, dogs with surgically confirmed IVDD were assayed for novel FGF4 retrocopies. Five additional and distinct FGF4 retrocopies were identified in canids including a copy unique to red wolves (Canis rufus). The FGF4 retrocopies identified in domestic dogs were identical to domestic dog FGF4 haplotypes, which are distinct from modern wolf FGF4 haplotypes, indicating that these retrotransposition events likely occurred after domestication. The identification of multiple, full length FGF4 retrocopies with open reading frames in canids indicates that gene retrotransposition events occur much more frequently than previously thought and provide a mechanism for continued genetic and phenotypic diversity in canids. Text Canis lupus Michigan Technological University: Digital Commons @ Michigan Tech |
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Michigan Technological University: Digital Commons @ Michigan Tech |
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ftmichigantuniv |
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unknown |
topic |
Canis lupus familiaris Duplication FGF4 Pseudogene Retrocopy Retrogene Retrotransposition College of Forest Resources and Environmental Science Forest Sciences |
spellingShingle |
Canis lupus familiaris Duplication FGF4 Pseudogene Retrocopy Retrogene Retrotransposition College of Forest Resources and Environmental Science Forest Sciences Batcher, Kevin Dickinson, Peter Maciejczyk, Kimberly Brzeski, Kristin Rasouliha, Sheida Hadji Letko, Anna Drögemüller, Cord Leeb, Tosso Bannasch, Danika Multiple FGF4 retrocopies recently derived within canids |
topic_facet |
Canis lupus familiaris Duplication FGF4 Pseudogene Retrocopy Retrogene Retrotransposition College of Forest Resources and Environmental Science Forest Sciences |
description |
Two transcribed retrocopies of the fibroblast growth factor 4 (FGF4) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebral disc disease (IVDD). In this study, whole-genome sequencing data were queried to identify other FGF4 retrocopies that could be contributing to phenotypic diversity in canids. Additionally, dogs with surgically confirmed IVDD were assayed for novel FGF4 retrocopies. Five additional and distinct FGF4 retrocopies were identified in canids including a copy unique to red wolves (Canis rufus). The FGF4 retrocopies identified in domestic dogs were identical to domestic dog FGF4 haplotypes, which are distinct from modern wolf FGF4 haplotypes, indicating that these retrotransposition events likely occurred after domestication. The identification of multiple, full length FGF4 retrocopies with open reading frames in canids indicates that gene retrotransposition events occur much more frequently than previously thought and provide a mechanism for continued genetic and phenotypic diversity in canids. |
format |
Text |
author |
Batcher, Kevin Dickinson, Peter Maciejczyk, Kimberly Brzeski, Kristin Rasouliha, Sheida Hadji Letko, Anna Drögemüller, Cord Leeb, Tosso Bannasch, Danika |
author_facet |
Batcher, Kevin Dickinson, Peter Maciejczyk, Kimberly Brzeski, Kristin Rasouliha, Sheida Hadji Letko, Anna Drögemüller, Cord Leeb, Tosso Bannasch, Danika |
author_sort |
Batcher, Kevin |
title |
Multiple FGF4 retrocopies recently derived within canids |
title_short |
Multiple FGF4 retrocopies recently derived within canids |
title_full |
Multiple FGF4 retrocopies recently derived within canids |
title_fullStr |
Multiple FGF4 retrocopies recently derived within canids |
title_full_unstemmed |
Multiple FGF4 retrocopies recently derived within canids |
title_sort |
multiple fgf4 retrocopies recently derived within canids |
publisher |
Digital Commons @ Michigan Tech |
publishDate |
2020 |
url |
https://digitalcommons.mtu.edu/michigantech-p/2673 https://digitalcommons.mtu.edu/cgi/viewcontent.cgi?article=3663&context=michigantech-p |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Michigan Tech Publications |
op_relation |
https://digitalcommons.mtu.edu/michigantech-p/2673 https://digitalcommons.mtu.edu/cgi/viewcontent.cgi?article=3663&context=michigantech-p |
op_rights |
http://creativecommons.org/licenses/by/4.0/ |
op_rightsnorm |
CC-BY |
_version_ |
1766385299449970688 |