Familial aggregation of fractures : a pilot study
Thesis (M.Sc.)--Memorial University of Newfoundland, 2011. Medicine Bibliography: leaves 61-73. Background: Childhood fractures are common and preventable. They are a significant cause of morbidity and are relatively understudied. Some children may have readily identifiable risk factors and examinat...
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ftmemorialunivdc:oai:collections.mun.ca:theses5/19423 2023-05-15T17:23:28+02:00 Familial aggregation of fractures : a pilot study Curtis, Sarah Joan, 1972- Memorial University of Newfoundland. Faculty of Medicine 2011 86 leaves in various pagings : col. ill. Image/jpeg; Application/pdf http://collections.mun.ca/cdm/ref/collection/theses5/id/19423 Eng eng Electronic Theses and Dissertations (9.70 MB) -- http://collections.mun.ca/PDFs/theses/Curtis_SarahJoan.pdf http://collections.mun.ca/cdm/ref/collection/theses5/id/19423 The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries Fractures in children--Genetic aspects Fractures in children--Environmental aspects Fractures in children--Risk factors Fractures Bone--genetics Child Risk Factors Text Electronic thesis or dissertation 2011 ftmemorialunivdc 2015-08-06T19:22:48Z Thesis (M.Sc.)--Memorial University of Newfoundland, 2011. Medicine Bibliography: leaves 61-73. Background: Childhood fractures are common and preventable. They are a significant cause of morbidity and are relatively understudied. Some children may have readily identifiable risk factors and examination of this possibility will help our understanding of pediatric fractures. -- Objectives: To investigate familial, environmental and other complex influences on fracture risk in children. -- Design/Methods: Case-control study of 150 children with and without fracture. -- Results: Children with fractures were more likely to have a parental history of fracture (46.8% of cases versus 31.0% of control; p=0.007). Odds ratios for fracture were 2.2 (p=0.036), 2.03 (p=0.035) and 3.7 (p= 0.009) if the child's mother, father or both parents fractured respectively. Cases were twice as likely to have siblings and 1.5 times as likely to have first-degree relatives with fracture. Increased parental fracture burden was seen in families of children with multiple fractures. Groups did not differ with respect to environmental influences on fracture risk. -- Conclusions: There appears to be an increased familial clustering of childhood fractures as children with fractures are more likely to have parents and siblings with childhood fractures. Explanations for this association between parental fractures and increased risk of fracture for their children are currently unknown. This association should be validated in larger sample sizes and the relative impact of genetic, environmental and behavioral factors need to be further elucidated. Thesis Newfoundland studies University of Newfoundland Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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ftmemorialunivdc |
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English |
topic |
Fractures in children--Genetic aspects Fractures in children--Environmental aspects Fractures in children--Risk factors Fractures Bone--genetics Child Risk Factors |
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Fractures in children--Genetic aspects Fractures in children--Environmental aspects Fractures in children--Risk factors Fractures Bone--genetics Child Risk Factors Curtis, Sarah Joan, 1972- Familial aggregation of fractures : a pilot study |
topic_facet |
Fractures in children--Genetic aspects Fractures in children--Environmental aspects Fractures in children--Risk factors Fractures Bone--genetics Child Risk Factors |
description |
Thesis (M.Sc.)--Memorial University of Newfoundland, 2011. Medicine Bibliography: leaves 61-73. Background: Childhood fractures are common and preventable. They are a significant cause of morbidity and are relatively understudied. Some children may have readily identifiable risk factors and examination of this possibility will help our understanding of pediatric fractures. -- Objectives: To investigate familial, environmental and other complex influences on fracture risk in children. -- Design/Methods: Case-control study of 150 children with and without fracture. -- Results: Children with fractures were more likely to have a parental history of fracture (46.8% of cases versus 31.0% of control; p=0.007). Odds ratios for fracture were 2.2 (p=0.036), 2.03 (p=0.035) and 3.7 (p= 0.009) if the child's mother, father or both parents fractured respectively. Cases were twice as likely to have siblings and 1.5 times as likely to have first-degree relatives with fracture. Increased parental fracture burden was seen in families of children with multiple fractures. Groups did not differ with respect to environmental influences on fracture risk. -- Conclusions: There appears to be an increased familial clustering of childhood fractures as children with fractures are more likely to have parents and siblings with childhood fractures. Explanations for this association between parental fractures and increased risk of fracture for their children are currently unknown. This association should be validated in larger sample sizes and the relative impact of genetic, environmental and behavioral factors need to be further elucidated. |
author2 |
Memorial University of Newfoundland. Faculty of Medicine |
format |
Thesis |
author |
Curtis, Sarah Joan, 1972- |
author_facet |
Curtis, Sarah Joan, 1972- |
author_sort |
Curtis, Sarah Joan, 1972- |
title |
Familial aggregation of fractures : a pilot study |
title_short |
Familial aggregation of fractures : a pilot study |
title_full |
Familial aggregation of fractures : a pilot study |
title_fullStr |
Familial aggregation of fractures : a pilot study |
title_full_unstemmed |
Familial aggregation of fractures : a pilot study |
title_sort |
familial aggregation of fractures : a pilot study |
publishDate |
2011 |
url |
http://collections.mun.ca/cdm/ref/collection/theses5/id/19423 |
genre |
Newfoundland studies University of Newfoundland |
genre_facet |
Newfoundland studies University of Newfoundland |
op_source |
Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries |
op_relation |
Electronic Theses and Dissertations (9.70 MB) -- http://collections.mun.ca/PDFs/theses/Curtis_SarahJoan.pdf http://collections.mun.ca/cdm/ref/collection/theses5/id/19423 |
op_rights |
The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. |
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1766112465438900224 |