Novel biodegradable and biocompatible elastomers for endostatin delivery
Thesis (M.Sc.)--Memorial University of Newfoundland, 2008. Pharmacy Includes bibliographical references. Long term, localized continuous release of Endostatin (END) in the vicinity of tumour bed represents a new strategy for neoplastic treatment. The main reason of localization is to maximize the th...
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ftmemorialunivdc:oai:collections.mun.ca:theses5/10328 2023-05-15T17:23:34+02:00 Novel biodegradable and biocompatible elastomers for endostatin delivery Ellaboudy, Hany, 1969- Memorial University of Newfoundland. School of Pharmacy 2008 xi, 128 leaves : ill. (some col.). Image/jpeg; Application/pdf http://collections.mun.ca/cdm/ref/collection/theses5/id/10328 Eng eng Electronic Theses and Dissertations (4.87 MB) -- http://collections.mun.ca/PDFs/theses/Ellaboudy_Hany.pdf a2766209 http://collections.mun.ca/cdm/ref/collection/theses5/id/10328 The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries Elastomers--Therapeutic use Neovascularization inhibitors Polymeric drug delivery systems Tumors--Treatment Text Electronic thesis or dissertation 2008 ftmemorialunivdc 2015-08-06T19:22:48Z Thesis (M.Sc.)--Memorial University of Newfoundland, 2008. Pharmacy Includes bibliographical references. Long term, localized continuous release of Endostatin (END) in the vicinity of tumour bed represents a new strategy for neoplastic treatment. The main reason of localization is to maximize the therapeutic outcome and at the same time to reduce the toxic effects on the surrounding tissues due to the exposure to the angiogenesis inhibitory effect of END. The main objective of this study was to design and formulate a biodegradable and biocompatible polymeric device for delivering END at a sustained and constant rate, and at a concentration within its therapeutic window by utilizing the osmotic release mechanism. The new device was prepared by mixing of END with osmotically active excipients and incorporate the mixture as solid particles within a rubbery polyermic matrix. The results demonstrated that this new device achieved a constant and sustained release rate for END for a certain period. Thesis Newfoundland studies University of Newfoundland Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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Open Polar |
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Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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ftmemorialunivdc |
language |
English |
topic |
Elastomers--Therapeutic use Neovascularization inhibitors Polymeric drug delivery systems Tumors--Treatment |
spellingShingle |
Elastomers--Therapeutic use Neovascularization inhibitors Polymeric drug delivery systems Tumors--Treatment Ellaboudy, Hany, 1969- Novel biodegradable and biocompatible elastomers for endostatin delivery |
topic_facet |
Elastomers--Therapeutic use Neovascularization inhibitors Polymeric drug delivery systems Tumors--Treatment |
description |
Thesis (M.Sc.)--Memorial University of Newfoundland, 2008. Pharmacy Includes bibliographical references. Long term, localized continuous release of Endostatin (END) in the vicinity of tumour bed represents a new strategy for neoplastic treatment. The main reason of localization is to maximize the therapeutic outcome and at the same time to reduce the toxic effects on the surrounding tissues due to the exposure to the angiogenesis inhibitory effect of END. The main objective of this study was to design and formulate a biodegradable and biocompatible polymeric device for delivering END at a sustained and constant rate, and at a concentration within its therapeutic window by utilizing the osmotic release mechanism. The new device was prepared by mixing of END with osmotically active excipients and incorporate the mixture as solid particles within a rubbery polyermic matrix. The results demonstrated that this new device achieved a constant and sustained release rate for END for a certain period. |
author2 |
Memorial University of Newfoundland. School of Pharmacy |
format |
Thesis |
author |
Ellaboudy, Hany, 1969- |
author_facet |
Ellaboudy, Hany, 1969- |
author_sort |
Ellaboudy, Hany, 1969- |
title |
Novel biodegradable and biocompatible elastomers for endostatin delivery |
title_short |
Novel biodegradable and biocompatible elastomers for endostatin delivery |
title_full |
Novel biodegradable and biocompatible elastomers for endostatin delivery |
title_fullStr |
Novel biodegradable and biocompatible elastomers for endostatin delivery |
title_full_unstemmed |
Novel biodegradable and biocompatible elastomers for endostatin delivery |
title_sort |
novel biodegradable and biocompatible elastomers for endostatin delivery |
publishDate |
2008 |
url |
http://collections.mun.ca/cdm/ref/collection/theses5/id/10328 |
genre |
Newfoundland studies University of Newfoundland |
genre_facet |
Newfoundland studies University of Newfoundland |
op_source |
Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries |
op_relation |
Electronic Theses and Dissertations (4.87 MB) -- http://collections.mun.ca/PDFs/theses/Ellaboudy_Hany.pdf a2766209 http://collections.mun.ca/cdm/ref/collection/theses5/id/10328 |
op_rights |
The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. |
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1766113364663074816 |