The effect of drug mitigated motion sickness on physiological and psychophysical performance
Thesis (M.Sc.)--Memorial University of Newfoundland, 2010. Human Kinetics and Recreation Includes bibliographical references (leaves 63-68) The purpose of this study was to measure physiological and psychophysical responses and cognitive performance of motion sickness (MS) susceptible individuals du...
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ftmemorialunivdc:oai:collections.mun.ca:theses4/91055 2023-05-15T17:23:33+02:00 The effect of drug mitigated motion sickness on physiological and psychophysical performance Coady, Elizabeth Anne, 1980- Memorial University of Newfoundland. School of Human Kinetics and Recreation 2010 vii, 85 leaves : ill. Image/jpeg; Application/pdf http://collections.mun.ca/cdm/ref/collection/theses4/id/91055 Eng eng Electronic Theses and Dissertations (10.44 MB) -- http://collections.mun.ca/PDFs/theses/Coady_ElizabethAnne.pdf a3474608 http://collections.mun.ca/cdm/ref/collection/theses4/id/91055 The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries Drug utilization--Evaluation Motion--Physiological aspects Movement Psychology of Simulator sickness--Treatment Text Electronic thesis or dissertation 2010 ftmemorialunivdc 2015-08-06T19:22:11Z Thesis (M.Sc.)--Memorial University of Newfoundland, 2010. Human Kinetics and Recreation Includes bibliographical references (leaves 63-68) The purpose of this study was to measure physiological and psychophysical responses and cognitive performance of motion sickness (MS) susceptible individuals during exposure to a ship motion simulator. Further, this study investigated the effects of selected classes of anti-MS drugs in suppressing motion sickness induced effects upon physiological adaptations, psychophysical responses and cognitive performance. Thirteen healthy male and female volunteers were recruited to take part in this research (25.1 ± 2.3 years, 79.2 ± 14.6 kg, 174.4 ±12.1 cm). Each participant ingested seven pharmaceutical preparations, 1 placebo and 6 anti-MS medications including Meclizine, Promethazine and Dexamphetamine, Promethazine and Caffeine, Dimenhydrinate, Scopolamine and Dexamphetamine and Chlorpheniramine prior to exposure to simulated ship motion on a 6 degree of freedom motion base. Sessions lasted up to one hour or until subjective MS ratings forced a termination of the trial. Subjective evaluations of MS symptom onset were taken using GraybiePs Diagnostic Criteria for Grading the Severity of Acute Motion Sickness and a 7-Point nausea rating scale. Defence Research Development Canada's Sustained Operations task batteries were employed to measure cognitive performance and were administered every 10 minutes throughout the motion exposure. Physiological measures, including core body temperature and skin temperatures were sampled continuously throughout the trial at 1 second intervals. A repeated measures ANOVA revealed no statistically significant differences in the physiological responses, however there was a significant difference found in the 7-point nausea scale rating evaluation of psychophysical responses. The placebo trial was significantly greater than any of the intervention trials. In addition to this significant difference, there were apparent rank order tendencies in response to the placebo and drug interventions. From these data there are trends indicating some drugs are better used in some scenarios, such as those requiring cognitive awareness and performance, while other drugs may be applied in situations where the main purpose is for the comfort of the passenger, or of someone whom vigilance and alertness is not required. Thesis Newfoundland studies University of Newfoundland Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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English |
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Drug utilization--Evaluation Motion--Physiological aspects Movement Psychology of Simulator sickness--Treatment |
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Drug utilization--Evaluation Motion--Physiological aspects Movement Psychology of Simulator sickness--Treatment Coady, Elizabeth Anne, 1980- The effect of drug mitigated motion sickness on physiological and psychophysical performance |
topic_facet |
Drug utilization--Evaluation Motion--Physiological aspects Movement Psychology of Simulator sickness--Treatment |
description |
Thesis (M.Sc.)--Memorial University of Newfoundland, 2010. Human Kinetics and Recreation Includes bibliographical references (leaves 63-68) The purpose of this study was to measure physiological and psychophysical responses and cognitive performance of motion sickness (MS) susceptible individuals during exposure to a ship motion simulator. Further, this study investigated the effects of selected classes of anti-MS drugs in suppressing motion sickness induced effects upon physiological adaptations, psychophysical responses and cognitive performance. Thirteen healthy male and female volunteers were recruited to take part in this research (25.1 ± 2.3 years, 79.2 ± 14.6 kg, 174.4 ±12.1 cm). Each participant ingested seven pharmaceutical preparations, 1 placebo and 6 anti-MS medications including Meclizine, Promethazine and Dexamphetamine, Promethazine and Caffeine, Dimenhydrinate, Scopolamine and Dexamphetamine and Chlorpheniramine prior to exposure to simulated ship motion on a 6 degree of freedom motion base. Sessions lasted up to one hour or until subjective MS ratings forced a termination of the trial. Subjective evaluations of MS symptom onset were taken using GraybiePs Diagnostic Criteria for Grading the Severity of Acute Motion Sickness and a 7-Point nausea rating scale. Defence Research Development Canada's Sustained Operations task batteries were employed to measure cognitive performance and were administered every 10 minutes throughout the motion exposure. Physiological measures, including core body temperature and skin temperatures were sampled continuously throughout the trial at 1 second intervals. A repeated measures ANOVA revealed no statistically significant differences in the physiological responses, however there was a significant difference found in the 7-point nausea scale rating evaluation of psychophysical responses. The placebo trial was significantly greater than any of the intervention trials. In addition to this significant difference, there were apparent rank order tendencies in response to the placebo and drug interventions. From these data there are trends indicating some drugs are better used in some scenarios, such as those requiring cognitive awareness and performance, while other drugs may be applied in situations where the main purpose is for the comfort of the passenger, or of someone whom vigilance and alertness is not required. |
author2 |
Memorial University of Newfoundland. School of Human Kinetics and Recreation |
format |
Thesis |
author |
Coady, Elizabeth Anne, 1980- |
author_facet |
Coady, Elizabeth Anne, 1980- |
author_sort |
Coady, Elizabeth Anne, 1980- |
title |
The effect of drug mitigated motion sickness on physiological and psychophysical performance |
title_short |
The effect of drug mitigated motion sickness on physiological and psychophysical performance |
title_full |
The effect of drug mitigated motion sickness on physiological and psychophysical performance |
title_fullStr |
The effect of drug mitigated motion sickness on physiological and psychophysical performance |
title_full_unstemmed |
The effect of drug mitigated motion sickness on physiological and psychophysical performance |
title_sort |
effect of drug mitigated motion sickness on physiological and psychophysical performance |
publishDate |
2010 |
url |
http://collections.mun.ca/cdm/ref/collection/theses4/id/91055 |
genre |
Newfoundland studies University of Newfoundland |
genre_facet |
Newfoundland studies University of Newfoundland |
op_source |
Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries |
op_relation |
Electronic Theses and Dissertations (10.44 MB) -- http://collections.mun.ca/PDFs/theses/Coady_ElizabethAnne.pdf a3474608 http://collections.mun.ca/cdm/ref/collection/theses4/id/91055 |
op_rights |
The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. |
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