The utility of HPV DNA testing in triage of low-grade cytological abnormalities
Thesis (M.Sc.)--Memorial University of Newfoundland, 2008. Medicine Includes bibliographical references (leaves 74-84) This study evaluated the usefulness of human papillomavirus (HPV) DNA testing and repeat cytology in triage of women referred to colposcopy in St. John's, Newfoundland with aty...
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ftmemorialunivdc:oai:collections.mun.ca:theses4/168935 2023-05-15T17:23:34+02:00 The utility of HPV DNA testing in triage of low-grade cytological abnormalities Halfyard, Beth Banks, 1978- Memorial University of Newfoundland. Faculty of Medicine 2008 xi, 86 leaves : ill. Image/jpeg; Application/pdf http://collections.mun.ca/cdm/ref/collection/theses4/id/168935 Eng eng Electronic Theses and Dissertations (10.23 MB) -- http://collections.mun.ca/PDFs/theses/Halfyard_BethBanks.pdf a2543857 http://collections.mun.ca/cdm/ref/collection/theses4/id/168935 The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries Cells--Abnormalities Cervix uteri--Cancer--Testing Papillomaviruses--Testing DNA Probes HPV Uterine Cervical Neoplasms Text Electronic thesis or dissertation 2008 ftmemorialunivdc 2015-08-06T19:22:43Z Thesis (M.Sc.)--Memorial University of Newfoundland, 2008. Medicine Includes bibliographical references (leaves 74-84) This study evaluated the usefulness of human papillomavirus (HPV) DNA testing and repeat cytology in triage of women referred to colposcopy in St. John's, Newfoundland with atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) cytology. Data were collected on the initial Pap abnormality that prompted referral, HPV test, repeat Pap test, and histology if biopsies were ordered. Of 447 women, 97 with ASCUS and 145 with LSIL had results for all tests. For ASCUS, HPV testing was 100% sensitive for detection of underlying high-grade intraepithelial lesions (HSIL) while reducing referrals to 44.3%. There would have been significant reductions in referrals among women ^30 years of age (74.3%) compared to younger women (27.4%). Nevertheless, in restricting HPV testing to women aged ^30 years, 8/16 women with underlying HSIL would not have been referred to colposcopy. Repeat cytology was less sensitive (75%) for triaging all women. For LSIL, any method would have referred approximately 60% or more if a good sensitivity was achieved in any age group. For ASCUS, HPV triage appears to be more useful than repeat cytology. No useful triage strategy was identified for LSIL. Thesis Newfoundland studies University of Newfoundland Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
op_collection_id |
ftmemorialunivdc |
language |
English |
topic |
Cells--Abnormalities Cervix uteri--Cancer--Testing Papillomaviruses--Testing DNA Probes HPV Uterine Cervical Neoplasms |
spellingShingle |
Cells--Abnormalities Cervix uteri--Cancer--Testing Papillomaviruses--Testing DNA Probes HPV Uterine Cervical Neoplasms Halfyard, Beth Banks, 1978- The utility of HPV DNA testing in triage of low-grade cytological abnormalities |
topic_facet |
Cells--Abnormalities Cervix uteri--Cancer--Testing Papillomaviruses--Testing DNA Probes HPV Uterine Cervical Neoplasms |
description |
Thesis (M.Sc.)--Memorial University of Newfoundland, 2008. Medicine Includes bibliographical references (leaves 74-84) This study evaluated the usefulness of human papillomavirus (HPV) DNA testing and repeat cytology in triage of women referred to colposcopy in St. John's, Newfoundland with atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesion (LSIL) cytology. Data were collected on the initial Pap abnormality that prompted referral, HPV test, repeat Pap test, and histology if biopsies were ordered. Of 447 women, 97 with ASCUS and 145 with LSIL had results for all tests. For ASCUS, HPV testing was 100% sensitive for detection of underlying high-grade intraepithelial lesions (HSIL) while reducing referrals to 44.3%. There would have been significant reductions in referrals among women ^30 years of age (74.3%) compared to younger women (27.4%). Nevertheless, in restricting HPV testing to women aged ^30 years, 8/16 women with underlying HSIL would not have been referred to colposcopy. Repeat cytology was less sensitive (75%) for triaging all women. For LSIL, any method would have referred approximately 60% or more if a good sensitivity was achieved in any age group. For ASCUS, HPV triage appears to be more useful than repeat cytology. No useful triage strategy was identified for LSIL. |
author2 |
Memorial University of Newfoundland. Faculty of Medicine |
format |
Thesis |
author |
Halfyard, Beth Banks, 1978- |
author_facet |
Halfyard, Beth Banks, 1978- |
author_sort |
Halfyard, Beth Banks, 1978- |
title |
The utility of HPV DNA testing in triage of low-grade cytological abnormalities |
title_short |
The utility of HPV DNA testing in triage of low-grade cytological abnormalities |
title_full |
The utility of HPV DNA testing in triage of low-grade cytological abnormalities |
title_fullStr |
The utility of HPV DNA testing in triage of low-grade cytological abnormalities |
title_full_unstemmed |
The utility of HPV DNA testing in triage of low-grade cytological abnormalities |
title_sort |
utility of hpv dna testing in triage of low-grade cytological abnormalities |
publishDate |
2008 |
url |
http://collections.mun.ca/cdm/ref/collection/theses4/id/168935 |
genre |
Newfoundland studies University of Newfoundland |
genre_facet |
Newfoundland studies University of Newfoundland |
op_source |
Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries |
op_relation |
Electronic Theses and Dissertations (10.23 MB) -- http://collections.mun.ca/PDFs/theses/Halfyard_BethBanks.pdf a2543857 http://collections.mun.ca/cdm/ref/collection/theses4/id/168935 |
op_rights |
The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. |
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1766113349303533568 |