Characterizing the neuroprotective efficacy of ischemic preconditioning (ischemic tolerance) : is age an important factor?
Thesis (Ph.D.)--Memorial University of Newfoundland, Faculty of Medicine, 2000. Medicine Bibliography: p. 137-164 In this dissertation, the phenomenon of ischemic preconditioning was investigated in a gerbil model of global ischemia. Specifically, the neuroprotective efficacy of ischemic preconditio...
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ftmemorialunivdc:oai:collections.mun.ca:theses3/92592 2023-05-15T17:23:32+02:00 Characterizing the neuroprotective efficacy of ischemic preconditioning (ischemic tolerance) : is age an important factor? Dowden, Jennifer, 1971- Memorial University of Newfoundland. Faculty of Medicine 1999 xvii, 164 leaves : ill. (some col.) Image/jpeg; Application/pdf http://collections.mun.ca/cdm/ref/collection/theses3/id/92592 eng eng Electronic Theses and Dissertations (16.79 MB) -- http://collections.mun.ca/PDFs/theses/Dowden_Jennifer.pdf a1476797 http://collections.mun.ca/cdm/ref/collection/theses3/id/92592 The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries Cerebral ischemia Brain Ischemia Ischemic Preconditioning Text Electronic thesis or dissertation 1999 ftmemorialunivdc 2015-08-06T19:18:45Z Thesis (Ph.D.)--Memorial University of Newfoundland, Faculty of Medicine, 2000. Medicine Bibliography: p. 137-164 In this dissertation, the phenomenon of ischemic preconditioning was investigated in a gerbil model of global ischemia. Specifically, the neuroprotective efficacy of ischemic preconditioning was evaluated in aged and young gerbils to determine if age is an important factor influencing outcome. Outcome was assessed using histological, behavioural and electrophysiological endpoints in order to ensure an accurate measure of the extent of neuroprotection. -- In the first experiment, ischemic preconditioning was assessed in 18-20 month old gerbils. Ischemic preconditioning conveyed robust and long-lasting functional and histological protection. Furthermore, it appeared to be more effective than what had been previously reported in young animals (3-5 months). -- In the second experiment, a direct comparison of ischemic preconditioning protection was made in young (3-5 months old) and aged gerbils (18 months old). It was determined that aged animals had a higher level of protection compared to young animals. In addition, the results of this experiment suggest that one mechanism by which ischemic preconditioning produces protection may involve activation of astrocytes in the CA1 region. -- Finally, in the last experiment, the partial protection provided by ischemic preconditioning was used as a model to determine if early postishemic behavioural testing affected CA1 cell survival. In this study, there were no differences in cell counts between animals that had been exposed to a novel environment (open field apparatus) and those that were not. Thesis Newfoundland studies University of Newfoundland Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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English |
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Cerebral ischemia Brain Ischemia Ischemic Preconditioning |
spellingShingle |
Cerebral ischemia Brain Ischemia Ischemic Preconditioning Dowden, Jennifer, 1971- Characterizing the neuroprotective efficacy of ischemic preconditioning (ischemic tolerance) : is age an important factor? |
topic_facet |
Cerebral ischemia Brain Ischemia Ischemic Preconditioning |
description |
Thesis (Ph.D.)--Memorial University of Newfoundland, Faculty of Medicine, 2000. Medicine Bibliography: p. 137-164 In this dissertation, the phenomenon of ischemic preconditioning was investigated in a gerbil model of global ischemia. Specifically, the neuroprotective efficacy of ischemic preconditioning was evaluated in aged and young gerbils to determine if age is an important factor influencing outcome. Outcome was assessed using histological, behavioural and electrophysiological endpoints in order to ensure an accurate measure of the extent of neuroprotection. -- In the first experiment, ischemic preconditioning was assessed in 18-20 month old gerbils. Ischemic preconditioning conveyed robust and long-lasting functional and histological protection. Furthermore, it appeared to be more effective than what had been previously reported in young animals (3-5 months). -- In the second experiment, a direct comparison of ischemic preconditioning protection was made in young (3-5 months old) and aged gerbils (18 months old). It was determined that aged animals had a higher level of protection compared to young animals. In addition, the results of this experiment suggest that one mechanism by which ischemic preconditioning produces protection may involve activation of astrocytes in the CA1 region. -- Finally, in the last experiment, the partial protection provided by ischemic preconditioning was used as a model to determine if early postishemic behavioural testing affected CA1 cell survival. In this study, there were no differences in cell counts between animals that had been exposed to a novel environment (open field apparatus) and those that were not. |
author2 |
Memorial University of Newfoundland. Faculty of Medicine |
format |
Thesis |
author |
Dowden, Jennifer, 1971- |
author_facet |
Dowden, Jennifer, 1971- |
author_sort |
Dowden, Jennifer, 1971- |
title |
Characterizing the neuroprotective efficacy of ischemic preconditioning (ischemic tolerance) : is age an important factor? |
title_short |
Characterizing the neuroprotective efficacy of ischemic preconditioning (ischemic tolerance) : is age an important factor? |
title_full |
Characterizing the neuroprotective efficacy of ischemic preconditioning (ischemic tolerance) : is age an important factor? |
title_fullStr |
Characterizing the neuroprotective efficacy of ischemic preconditioning (ischemic tolerance) : is age an important factor? |
title_full_unstemmed |
Characterizing the neuroprotective efficacy of ischemic preconditioning (ischemic tolerance) : is age an important factor? |
title_sort |
characterizing the neuroprotective efficacy of ischemic preconditioning (ischemic tolerance) : is age an important factor? |
publishDate |
1999 |
url |
http://collections.mun.ca/cdm/ref/collection/theses3/id/92592 |
genre |
Newfoundland studies University of Newfoundland |
genre_facet |
Newfoundland studies University of Newfoundland |
op_source |
Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries |
op_relation |
Electronic Theses and Dissertations (16.79 MB) -- http://collections.mun.ca/PDFs/theses/Dowden_Jennifer.pdf a1476797 http://collections.mun.ca/cdm/ref/collection/theses3/id/92592 |
op_rights |
The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. |
_version_ |
1766113116150562816 |