Randomized comparison of oral misoprostol and oxytocin in the third stage of labour
Thesis (M.Sc.)--Memorial University of Newfoundland, 2000. Medicine Bibliography: leaves 51-55 Objective: To test the null hypothesis that misoprostol, an oral prostaglandin El analog, is not worse than oxytocin intravenous bolus in minimizing blood loss in the third stage of labour. -- Method: One...
Main Author: | |
---|---|
Other Authors: | |
Format: | Thesis |
Language: | English |
Published: |
1999
|
Subjects: | |
Online Access: | http://collections.mun.ca/cdm/ref/collection/theses3/id/202735 |
id |
ftmemorialunivdc:oai:collections.mun.ca:theses3/202735 |
---|---|
record_format |
openpolar |
spelling |
ftmemorialunivdc:oai:collections.mun.ca:theses3/202735 2023-05-15T17:23:33+02:00 Randomized comparison of oral misoprostol and oxytocin in the third stage of labour Bajzak, Krisztina, 1969- Memorial University of Newfoundland. Faculty of Medicine 1999 x, 76 leaves : ill. Image/jpeg; Application/pdf http://collections.mun.ca/cdm/ref/collection/theses3/id/202735 eng eng Electronic Theses and Dissertations (6.67 MB) -- http://collections.mun.ca/PDFs/theses/Bajzak_Krisztina.pdf a1493415 http://collections.mun.ca/cdm/ref/collection/theses3/id/202735 The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries Labor (Obstetrics)--Complications--Treatment Uterine hemorrhage--Treatment Oxytocin--therapeutic use Misoprostol--therapeutic use Uterine Hemorrhage--drug therapy Labor Obstetric Text Electronic thesis or dissertation 1999 ftmemorialunivdc 2015-08-06T19:20:53Z Thesis (M.Sc.)--Memorial University of Newfoundland, 2000. Medicine Bibliography: leaves 51-55 Objective: To test the null hypothesis that misoprostol, an oral prostaglandin El analog, is not worse than oxytocin intravenous bolus in minimizing blood loss in the third stage of labour. -- Method: One hundred and fifty-six women, having vaginal delivery and at low risk of postpartum hemorrhage, were stratified by oxytocin use in labour and randomly assigned to receive either misoprostol 200|ig orally with the anterior shoulder, or oxytocin intravenous bolus after placental delivery, the standard at our institution. Sample size was calculated using a one-tailed a=0.05 and a power of 80%, with change in pre-delivery to 1st day postpartum hematocrit as the primary outcome. -- Results: Baseline demographic data were similar. There was no significant difference in the change in hematocrit between the misoprostol (0.046% packed cell volume[PCV]) and the oxytocin (0.048% PCV) groups (P=0.49). More women in the oxytocin stratum received additional oxytocin postpartum (P=0.002). There were no differences in the frequency of clinical estimate of postpartum blood loss greater than 500mL, use of other uterotonic agents, manual removal of placenta, dilation and currettage, transfusion, gastrointestinal side effects, or maternal satisfaction. There were no differences in frequency of maternal fever postpartum. After delivery, more women in the misoprostol group strongly preferred to have a medication in the form of a pill, rather than an intravenous injection, at the time of delivery of their baby (82.8% versus 42.2%, P<0.00001, Mann Whitney test) -- Conclusions: Oral misoprostol is a safe and effective option to minimize blood loss in the third stage of labour, for women at low risk of postpartum hemorrhage. Thesis Newfoundland studies University of Newfoundland Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
institution |
Open Polar |
collection |
Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
op_collection_id |
ftmemorialunivdc |
language |
English |
topic |
Labor (Obstetrics)--Complications--Treatment Uterine hemorrhage--Treatment Oxytocin--therapeutic use Misoprostol--therapeutic use Uterine Hemorrhage--drug therapy Labor Obstetric |
spellingShingle |
Labor (Obstetrics)--Complications--Treatment Uterine hemorrhage--Treatment Oxytocin--therapeutic use Misoprostol--therapeutic use Uterine Hemorrhage--drug therapy Labor Obstetric Bajzak, Krisztina, 1969- Randomized comparison of oral misoprostol and oxytocin in the third stage of labour |
topic_facet |
Labor (Obstetrics)--Complications--Treatment Uterine hemorrhage--Treatment Oxytocin--therapeutic use Misoprostol--therapeutic use Uterine Hemorrhage--drug therapy Labor Obstetric |
description |
Thesis (M.Sc.)--Memorial University of Newfoundland, 2000. Medicine Bibliography: leaves 51-55 Objective: To test the null hypothesis that misoprostol, an oral prostaglandin El analog, is not worse than oxytocin intravenous bolus in minimizing blood loss in the third stage of labour. -- Method: One hundred and fifty-six women, having vaginal delivery and at low risk of postpartum hemorrhage, were stratified by oxytocin use in labour and randomly assigned to receive either misoprostol 200|ig orally with the anterior shoulder, or oxytocin intravenous bolus after placental delivery, the standard at our institution. Sample size was calculated using a one-tailed a=0.05 and a power of 80%, with change in pre-delivery to 1st day postpartum hematocrit as the primary outcome. -- Results: Baseline demographic data were similar. There was no significant difference in the change in hematocrit between the misoprostol (0.046% packed cell volume[PCV]) and the oxytocin (0.048% PCV) groups (P=0.49). More women in the oxytocin stratum received additional oxytocin postpartum (P=0.002). There were no differences in the frequency of clinical estimate of postpartum blood loss greater than 500mL, use of other uterotonic agents, manual removal of placenta, dilation and currettage, transfusion, gastrointestinal side effects, or maternal satisfaction. There were no differences in frequency of maternal fever postpartum. After delivery, more women in the misoprostol group strongly preferred to have a medication in the form of a pill, rather than an intravenous injection, at the time of delivery of their baby (82.8% versus 42.2%, P<0.00001, Mann Whitney test) -- Conclusions: Oral misoprostol is a safe and effective option to minimize blood loss in the third stage of labour, for women at low risk of postpartum hemorrhage. |
author2 |
Memorial University of Newfoundland. Faculty of Medicine |
format |
Thesis |
author |
Bajzak, Krisztina, 1969- |
author_facet |
Bajzak, Krisztina, 1969- |
author_sort |
Bajzak, Krisztina, 1969- |
title |
Randomized comparison of oral misoprostol and oxytocin in the third stage of labour |
title_short |
Randomized comparison of oral misoprostol and oxytocin in the third stage of labour |
title_full |
Randomized comparison of oral misoprostol and oxytocin in the third stage of labour |
title_fullStr |
Randomized comparison of oral misoprostol and oxytocin in the third stage of labour |
title_full_unstemmed |
Randomized comparison of oral misoprostol and oxytocin in the third stage of labour |
title_sort |
randomized comparison of oral misoprostol and oxytocin in the third stage of labour |
publishDate |
1999 |
url |
http://collections.mun.ca/cdm/ref/collection/theses3/id/202735 |
genre |
Newfoundland studies University of Newfoundland |
genre_facet |
Newfoundland studies University of Newfoundland |
op_source |
Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries |
op_relation |
Electronic Theses and Dissertations (6.67 MB) -- http://collections.mun.ca/PDFs/theses/Bajzak_Krisztina.pdf a1493415 http://collections.mun.ca/cdm/ref/collection/theses3/id/202735 |
op_rights |
The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. |
_version_ |
1766113196173688832 |