Effects of environmental enrichment on ischemic tolerance
Thesis (M.Sc.)--Memorial University of Newfoundland, 2002. Medicine Bibliography: leaves 72-92 In this study, we sought to determine whether environmental enrichment could alter the pattern of delayed CA1 cell death and functional impairment in a gerbil model of ischemic tolerance. Gerbils received...
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ftmemorialunivdc:oai:collections.mun.ca:theses3/14113 2023-05-15T17:23:32+02:00 Effects of environmental enrichment on ischemic tolerance Farrell, Rosemarie, 1975- Memorial University of Newfoundland. Faculty of Medicine 2001 viii, 92 leaves : ill. (some col.) Image/jpeg; Application/pdf http://collections.mun.ca/cdm/ref/collection/theses3/id/14113 Eng eng Electronic Theses and Dissertations (22.15 MB) -- http://collections.mun.ca/PDFs/theses/Farrell_Rosemarie.pdf a1562175 http://collections.mun.ca/cdm/ref/collection/theses3/id/14113 The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries Cerebral ischemia--Treatment Brain Ischemia--therapy Text Electronic thesis or dissertation 2001 ftmemorialunivdc 2015-08-06T19:17:43Z Thesis (M.Sc.)--Memorial University of Newfoundland, 2002. Medicine Bibliography: leaves 72-92 In this study, we sought to determine whether environmental enrichment could alter the pattern of delayed CA1 cell death and functional impairment in a gerbil model of ischemic tolerance. Gerbils received either ischemic preconditioning. 5 minutes of ischemia or sham surgery. Three days after ischemia, gerbils were placed in either an enriched environment or standard laboratory housing. Animals were tested in an open field arena followed by two versions of a T-maze task. Following behavioural testing, extracellular CA1 field potential amplitudes and CA1 cell counts were determined. In open field testing (day 60), enriched, ischemic preconditioned and ischemic gerbils were not different than shams whereas, non-enriched, ischemic preconditioned and ischemic gerbils continued to have higher activity scores. Preconditioned and enriched ischemic animals learned the win-shift T-maze problem as quickly as shams, whereas, only the enriched preconditioned group acquired the win-stay paradigm. Surprisingly. CA1 cell counts were significantly lower in enriched versus non-enriched ischemic preconditioned animals. -- These data demonstrate that early, intensive intervention after ischemia can improve functional outcome but this is accompanied by increased brain damage. Thesis Newfoundland studies University of Newfoundland Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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English |
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Cerebral ischemia--Treatment Brain Ischemia--therapy |
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Cerebral ischemia--Treatment Brain Ischemia--therapy Farrell, Rosemarie, 1975- Effects of environmental enrichment on ischemic tolerance |
topic_facet |
Cerebral ischemia--Treatment Brain Ischemia--therapy |
description |
Thesis (M.Sc.)--Memorial University of Newfoundland, 2002. Medicine Bibliography: leaves 72-92 In this study, we sought to determine whether environmental enrichment could alter the pattern of delayed CA1 cell death and functional impairment in a gerbil model of ischemic tolerance. Gerbils received either ischemic preconditioning. 5 minutes of ischemia or sham surgery. Three days after ischemia, gerbils were placed in either an enriched environment or standard laboratory housing. Animals were tested in an open field arena followed by two versions of a T-maze task. Following behavioural testing, extracellular CA1 field potential amplitudes and CA1 cell counts were determined. In open field testing (day 60), enriched, ischemic preconditioned and ischemic gerbils were not different than shams whereas, non-enriched, ischemic preconditioned and ischemic gerbils continued to have higher activity scores. Preconditioned and enriched ischemic animals learned the win-shift T-maze problem as quickly as shams, whereas, only the enriched preconditioned group acquired the win-stay paradigm. Surprisingly. CA1 cell counts were significantly lower in enriched versus non-enriched ischemic preconditioned animals. -- These data demonstrate that early, intensive intervention after ischemia can improve functional outcome but this is accompanied by increased brain damage. |
author2 |
Memorial University of Newfoundland. Faculty of Medicine |
format |
Thesis |
author |
Farrell, Rosemarie, 1975- |
author_facet |
Farrell, Rosemarie, 1975- |
author_sort |
Farrell, Rosemarie, 1975- |
title |
Effects of environmental enrichment on ischemic tolerance |
title_short |
Effects of environmental enrichment on ischemic tolerance |
title_full |
Effects of environmental enrichment on ischemic tolerance |
title_fullStr |
Effects of environmental enrichment on ischemic tolerance |
title_full_unstemmed |
Effects of environmental enrichment on ischemic tolerance |
title_sort |
effects of environmental enrichment on ischemic tolerance |
publishDate |
2001 |
url |
http://collections.mun.ca/cdm/ref/collection/theses3/id/14113 |
genre |
Newfoundland studies University of Newfoundland |
genre_facet |
Newfoundland studies University of Newfoundland |
op_source |
Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries |
op_relation |
Electronic Theses and Dissertations (22.15 MB) -- http://collections.mun.ca/PDFs/theses/Farrell_Rosemarie.pdf a1562175 http://collections.mun.ca/cdm/ref/collection/theses3/id/14113 |
op_rights |
The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. |
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