Statistical inference for treatments versus a control

• Main Author: Peng, Jianan, 1966-
• Other Authors: Memorial University of Newfoundland. Dept. of Mathematics and Statistics
• Format: Thesis
• Language: English
• Published: 2002
• Subjects: Order statistics; Placebos (Medicine); Newfoundland studies; University of Newfoundland
• Online Access: http://collections.mun.ca/cdm/ref/collection/theses3/id/134234

Thesis (Ph.D.)--Memorial University of Newfoundland, 2002. Mathematics and Statistics Bibliography: leaves 148-157 The treatments versus a control problem occurs in many scientific fields, with a major portion in medical research. Its primary goal is to determine if the response to one or more treatments differ from the response to a control or existing standard and if so, further to identify which treatments are better than the control. In many experiments, one often has a prior knowledge that the treatments are at least as effective as the control. It is well known that utilization of ordering information increases the efficiency of statistical inference procedures. The aim of this thesis is to develop some new statistical inference procedures for the problem by utilizing the prior information. -- In particular, simultaneous confidence lower bounds for the differences between treatment means and the control mean are considered. Efficient computation algorithms are proposed to obtain the optimal lower bounds between the best treatment mean and the control mean. Multiple contrast tests which take account of the prior knowledge play an important role in this thesis. -- Power studies via simulation compare the new proposed procedures with Dunnett's procedure and the likelihood ratio test. The new proposed procedures are also illustrated by some real data sets.