The development and interaction of catecholaminergic and peptidergic perivascular nerve fibres in the rat mesenteric vascular bed
Thesis (M.Sc.)--Memorial University of Newfoundland, 1989. Medicine Bibliography: leaves 99-113. The hypothesis that different fibre systems interact during the development of innervation of the mesenteric vascular bed was examined. It is proposed that this interaction may be essential to the develo...
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ftmemorialunivdc:oai:collections.mun.ca:theses2/240108 2023-05-15T17:23:31+02:00 The development and interaction of catecholaminergic and peptidergic perivascular nerve fibres in the rat mesenteric vascular bed Woolgar, Jane R. (Jane Ruth), 1964- Memorial University of Newfoundland. Faculty of Medicine 1988 viii, 117 leaves : ill. Image/jpeg; Application/pdf http://collections.mun.ca/cdm/ref/collection/theses2/id/240108 Eng eng Electronic Theses and Dissertations (23.15 MB) -- http://collections.mun.ca/PDFs/theses/Woolgar_JaneR.pdf 76083068 http://collections.mun.ca/cdm/ref/collection/theses2/id/240108 The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries Catecholamines Peptides Neurofibrils Vascular smooth muscle Text Electronic thesis or dissertation 1988 ftmemorialunivdc 2015-08-06T19:17:32Z Thesis (M.Sc.)--Memorial University of Newfoundland, 1989. Medicine Bibliography: leaves 99-113. The hypothesis that different fibre systems interact during the development of innervation of the mesenteric vascular bed was examined. It is proposed that this interaction may be essential to the development of each innervating system and in turn affect the development of the vasculature. Immunohistochemistry was used to allow differentiation of different fibre types. Electron microscopy was used to determine relationships between axons. Although it is still premature to draw a final conclusion, the results of the present studies suggest that peptide-containing and noradrenergic nerves follow different patterns of development and that they interact during development. It appears as if peptidergic innervation limits the proliferation of catecholaminergic fibres, whereas catecholaminergic fibres are necessary for the full development of peptidergic fibres. The peptidergic fibres are normally found in large bundles whereas the catecholaminergic fibres are found in small bundles. A mixing of these catecholaminergic and peptidergic fibres can occur. Colocalization of peptidergic and catecholaminergic substances in the same fibre also appears to be possible. Thesis Newfoundland studies University of Newfoundland Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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Memorial University of Newfoundland: Digital Archives Initiative (DAI) |
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language |
English |
topic |
Catecholamines Peptides Neurofibrils Vascular smooth muscle |
spellingShingle |
Catecholamines Peptides Neurofibrils Vascular smooth muscle Woolgar, Jane R. (Jane Ruth), 1964- The development and interaction of catecholaminergic and peptidergic perivascular nerve fibres in the rat mesenteric vascular bed |
topic_facet |
Catecholamines Peptides Neurofibrils Vascular smooth muscle |
description |
Thesis (M.Sc.)--Memorial University of Newfoundland, 1989. Medicine Bibliography: leaves 99-113. The hypothesis that different fibre systems interact during the development of innervation of the mesenteric vascular bed was examined. It is proposed that this interaction may be essential to the development of each innervating system and in turn affect the development of the vasculature. Immunohistochemistry was used to allow differentiation of different fibre types. Electron microscopy was used to determine relationships between axons. Although it is still premature to draw a final conclusion, the results of the present studies suggest that peptide-containing and noradrenergic nerves follow different patterns of development and that they interact during development. It appears as if peptidergic innervation limits the proliferation of catecholaminergic fibres, whereas catecholaminergic fibres are necessary for the full development of peptidergic fibres. The peptidergic fibres are normally found in large bundles whereas the catecholaminergic fibres are found in small bundles. A mixing of these catecholaminergic and peptidergic fibres can occur. Colocalization of peptidergic and catecholaminergic substances in the same fibre also appears to be possible. |
author2 |
Memorial University of Newfoundland. Faculty of Medicine |
format |
Thesis |
author |
Woolgar, Jane R. (Jane Ruth), 1964- |
author_facet |
Woolgar, Jane R. (Jane Ruth), 1964- |
author_sort |
Woolgar, Jane R. (Jane Ruth), 1964- |
title |
The development and interaction of catecholaminergic and peptidergic perivascular nerve fibres in the rat mesenteric vascular bed |
title_short |
The development and interaction of catecholaminergic and peptidergic perivascular nerve fibres in the rat mesenteric vascular bed |
title_full |
The development and interaction of catecholaminergic and peptidergic perivascular nerve fibres in the rat mesenteric vascular bed |
title_fullStr |
The development and interaction of catecholaminergic and peptidergic perivascular nerve fibres in the rat mesenteric vascular bed |
title_full_unstemmed |
The development and interaction of catecholaminergic and peptidergic perivascular nerve fibres in the rat mesenteric vascular bed |
title_sort |
development and interaction of catecholaminergic and peptidergic perivascular nerve fibres in the rat mesenteric vascular bed |
publishDate |
1988 |
url |
http://collections.mun.ca/cdm/ref/collection/theses2/id/240108 |
genre |
Newfoundland studies University of Newfoundland |
genre_facet |
Newfoundland studies University of Newfoundland |
op_source |
Paper copy kept in the Centre for Newfoundland Studies, Memorial University Libraries |
op_relation |
Electronic Theses and Dissertations (23.15 MB) -- http://collections.mun.ca/PDFs/theses/Woolgar_JaneR.pdf 76083068 http://collections.mun.ca/cdm/ref/collection/theses2/id/240108 |
op_rights |
The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author's permission. |
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1766112998006456320 |