Endocrine regulation of appetite and growth in Atlantic cod (Gadus morhua)
Atlantic cod, Gadus morhua, is an important commercial fisheries species in many North Atlantic countries. Due to the recent decline in cod populations worldwide, Atlantic cod has become an emerging species in aquaculture in Canada, in particular New Brunswick, and Newfoundland and Labrador. The wel...
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ftmemorialuniv:oai:research.library.mun.ca:8760 2023-10-01T03:54:30+02:00 Endocrine regulation of appetite and growth in Atlantic cod (Gadus morhua) Xu, Meiyu 2009 application/pdf https://research.library.mun.ca/8760/ https://research.library.mun.ca/8760/1/Xu_Meiyu.pdf en eng Memorial University of Newfoundland https://research.library.mun.ca/8760/1/Xu_Meiyu.pdf Xu, Meiyu <https://research.library.mun.ca/view/creator_az/Xu=3AMeiyu=3A=3A.html> (2009) Endocrine regulation of appetite and growth in Atlantic cod (Gadus morhua). Doctoral (PhD) thesis, Memorial University of Newfoundland. thesis_license Thesis NonPeerReviewed 2009 ftmemorialuniv 2023-09-03T06:47:03Z Atlantic cod, Gadus morhua, is an important commercial fisheries species in many North Atlantic countries. Due to the recent decline in cod populations worldwide, Atlantic cod has become an emerging species in aquaculture in Canada, in particular New Brunswick, and Newfoundland and Labrador. The well-developed resistance to long-term starvation also makes cod a good model for the study of growth- and appetite-related hormones under both short-and long-term nutritional changes. The endocrinal regulation of food intake and energy homeostasis involves a two-way communication of hormones existing in central nervous system and several peripheral organs. I aimed to identify and characterizing genes coding for two growth-related factors (PACAP and SS), as well as one central (OX) and two peripheral (ghrelin and GRP) appetite-related factors in Atlantic cod. Multiple alignments and phylogenetic analyses show that the amino acid sequences all 5 peptides appear relatively conserved among fish, at least among teleosts. The typical expression patterns reflect their functional regions and are highly similar to those of other teleosts reported so far, with high forebrain expression levels for brain peptides and high stomach expression levels for gut peptides. For all the peptides in the present study, an early appearance in development probably indicates a crucial role in development. The apparent differences of expression for PPSS 1, OX and NPY before and after first larval feeding suggest that growth and appetite in fish are already under strict endocrine regulation at very early stages of life. The different expression patterns displayed by PPSS 1 and PRP/PACAP during fasting and re-feeding indicate that they might have distinct functions in the regulation of feeding and metabolism of Atlantic cod. OX and NPY both display periprandial changes and appear to be more affected by re-feeding than a long fasting period, while an increase in CART expression was induced during long-term food deprivation. Ghrelin displayed ... Thesis atlantic cod Gadus morhua Newfoundland North Atlantic Memorial University of Newfoundland: Research Repository Newfoundland Canada |
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Memorial University of Newfoundland: Research Repository |
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ftmemorialuniv |
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English |
description |
Atlantic cod, Gadus morhua, is an important commercial fisheries species in many North Atlantic countries. Due to the recent decline in cod populations worldwide, Atlantic cod has become an emerging species in aquaculture in Canada, in particular New Brunswick, and Newfoundland and Labrador. The well-developed resistance to long-term starvation also makes cod a good model for the study of growth- and appetite-related hormones under both short-and long-term nutritional changes. The endocrinal regulation of food intake and energy homeostasis involves a two-way communication of hormones existing in central nervous system and several peripheral organs. I aimed to identify and characterizing genes coding for two growth-related factors (PACAP and SS), as well as one central (OX) and two peripheral (ghrelin and GRP) appetite-related factors in Atlantic cod. Multiple alignments and phylogenetic analyses show that the amino acid sequences all 5 peptides appear relatively conserved among fish, at least among teleosts. The typical expression patterns reflect their functional regions and are highly similar to those of other teleosts reported so far, with high forebrain expression levels for brain peptides and high stomach expression levels for gut peptides. For all the peptides in the present study, an early appearance in development probably indicates a crucial role in development. The apparent differences of expression for PPSS 1, OX and NPY before and after first larval feeding suggest that growth and appetite in fish are already under strict endocrine regulation at very early stages of life. The different expression patterns displayed by PPSS 1 and PRP/PACAP during fasting and re-feeding indicate that they might have distinct functions in the regulation of feeding and metabolism of Atlantic cod. OX and NPY both display periprandial changes and appear to be more affected by re-feeding than a long fasting period, while an increase in CART expression was induced during long-term food deprivation. Ghrelin displayed ... |
format |
Thesis |
author |
Xu, Meiyu |
spellingShingle |
Xu, Meiyu Endocrine regulation of appetite and growth in Atlantic cod (Gadus morhua) |
author_facet |
Xu, Meiyu |
author_sort |
Xu, Meiyu |
title |
Endocrine regulation of appetite and growth in Atlantic cod (Gadus morhua) |
title_short |
Endocrine regulation of appetite and growth in Atlantic cod (Gadus morhua) |
title_full |
Endocrine regulation of appetite and growth in Atlantic cod (Gadus morhua) |
title_fullStr |
Endocrine regulation of appetite and growth in Atlantic cod (Gadus morhua) |
title_full_unstemmed |
Endocrine regulation of appetite and growth in Atlantic cod (Gadus morhua) |
title_sort |
endocrine regulation of appetite and growth in atlantic cod (gadus morhua) |
publisher |
Memorial University of Newfoundland |
publishDate |
2009 |
url |
https://research.library.mun.ca/8760/ https://research.library.mun.ca/8760/1/Xu_Meiyu.pdf |
geographic |
Newfoundland Canada |
geographic_facet |
Newfoundland Canada |
genre |
atlantic cod Gadus morhua Newfoundland North Atlantic |
genre_facet |
atlantic cod Gadus morhua Newfoundland North Atlantic |
op_relation |
https://research.library.mun.ca/8760/1/Xu_Meiyu.pdf Xu, Meiyu <https://research.library.mun.ca/view/creator_az/Xu=3AMeiyu=3A=3A.html> (2009) Endocrine regulation of appetite and growth in Atlantic cod (Gadus morhua). Doctoral (PhD) thesis, Memorial University of Newfoundland. |
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thesis_license |
_version_ |
1778522247229603840 |