Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study
Objective Ghrelin is a 28-amino acid orexigenic peptide synthesized mainly in the stomach. Acute administration of ghrelin has been found to decrease insulin secretion. However, little data is available regarding whether ghrelin contributes to the long-term regulation of insulin resistance at the po...
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ftmemorialuniv:oai:research.library.mun.ca:605 2023-10-01T03:57:34+02:00 Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study Amini, Peyvand Wadden, Danny Cahill, Farrell Randell, Edward Vasdev, Sudesh Chen, Xihua Gulliver, Wayne Zhang, Weizhen Zhang, Hongwei Yi, Yanqing Sun, Guang 2012-09-20 application/pdf https://research.library.mun.ca/605/ https://research.library.mun.ca/605/1/serum_acylated_ghrelin.pdf https://research.library.mun.ca/605/3/serum_acylated_ghrelin.pdf https://doi.org/10.1371/journal.pone.0045657 en eng Public Library of Science https://research.library.mun.ca/605/1/serum_acylated_ghrelin.pdf https://research.library.mun.ca/605/3/serum_acylated_ghrelin.pdf Amini, Peyvand <https://research.library.mun.ca/view/creator_az/Amini=3APeyvand=3A=3A.html> and Wadden, Danny <https://research.library.mun.ca/view/creator_az/Wadden=3ADanny=3A=3A.html> and Cahill, Farrell <https://research.library.mun.ca/view/creator_az/Cahill=3AFarrell=3A=3A.html> and Randell, Edward <https://research.library.mun.ca/view/creator_az/Randell=3AEdward=3A=3A.html> and Vasdev, Sudesh <https://research.library.mun.ca/view/creator_az/Vasdev=3ASudesh=3A=3A.html> and Chen, Xihua <https://research.library.mun.ca/view/creator_az/Chen=3AXihua=3A=3A.html> and Gulliver, Wayne <https://research.library.mun.ca/view/creator_az/Gulliver=3AWayne=3A=3A.html> and Zhang, Weizhen <https://research.library.mun.ca/view/creator_az/Zhang=3AWeizhen=3A=3A.html> and Zhang, Hongwei <https://research.library.mun.ca/view/creator_az/Zhang=3AHongwei=3A=3A.html> and Yi, Yanqing <https://research.library.mun.ca/view/creator_az/Yi=3AYanqing=3A=3A.html> and Sun, Guang <https://research.library.mun.ca/view/creator_az/Sun=3AGuang=3A=3A.html> (2012) Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study. PLoS ONE, 7 (9). pp. 1-7. ISSN 1932-6203 cc_by Q Science (General) Article PeerReviewed 2012 ftmemorialuniv https://doi.org/10.1371/journal.pone.0045657 2023-09-03T06:44:00Z Objective Ghrelin is a 28-amino acid orexigenic peptide synthesized mainly in the stomach. Acute administration of ghrelin has been found to decrease insulin secretion. However, little data is available regarding whether ghrelin contributes to the long-term regulation of insulin resistance at the population level. The aim of this study is to investigate the association between circulating ghrelin and insulin resistance in a large population based study. Design A total of 2082 CODING study (Complex Diseases in the Newfoundland population: Environment and Genetics) subjects were assessed. Subjects were of at least third generation Newfoundland descent, between the ages of 20 and 79 years, and had no serious metabolic, cardiovascular, or endocrine diseases. Ghrelin was measured with an Enzyme Immunoassay method. Insulin and fasting glucose were measured by Immulite 2500 autoanalyzer and Lx20 clinical chemistry analyzer, respectively. Homeostatic Model Assessment of β cell function (HOMA-β) and Insulin Resistance (HOMA-IR) and Quantitative Insulin-sensitivity Check Index (QUICKI) were used for measurement of insulin resistance. Results Partial correlation analyses showed a significant negative correlation between circulating ghrelin and insulin level and insulin resistance in the entire cohort and also in men and women separately. The aforementioned correlation was independent of age, percentage of trunk fat and HDL-cholesterol. According to menopausal status, only pre-menopausal women revealed negative correlations. Conclusion Our results suggest that except for postmenopausal women, high circulating ghrelin level is associated with lower insulin resistance in the general population. Article in Journal/Newspaper Newfoundland Memorial University of Newfoundland: Research Repository PLoS ONE 7 9 e45657 |
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Memorial University of Newfoundland: Research Repository |
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ftmemorialuniv |
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English |
topic |
Q Science (General) |
spellingShingle |
Q Science (General) Amini, Peyvand Wadden, Danny Cahill, Farrell Randell, Edward Vasdev, Sudesh Chen, Xihua Gulliver, Wayne Zhang, Weizhen Zhang, Hongwei Yi, Yanqing Sun, Guang Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study |
topic_facet |
Q Science (General) |
description |
Objective Ghrelin is a 28-amino acid orexigenic peptide synthesized mainly in the stomach. Acute administration of ghrelin has been found to decrease insulin secretion. However, little data is available regarding whether ghrelin contributes to the long-term regulation of insulin resistance at the population level. The aim of this study is to investigate the association between circulating ghrelin and insulin resistance in a large population based study. Design A total of 2082 CODING study (Complex Diseases in the Newfoundland population: Environment and Genetics) subjects were assessed. Subjects were of at least third generation Newfoundland descent, between the ages of 20 and 79 years, and had no serious metabolic, cardiovascular, or endocrine diseases. Ghrelin was measured with an Enzyme Immunoassay method. Insulin and fasting glucose were measured by Immulite 2500 autoanalyzer and Lx20 clinical chemistry analyzer, respectively. Homeostatic Model Assessment of β cell function (HOMA-β) and Insulin Resistance (HOMA-IR) and Quantitative Insulin-sensitivity Check Index (QUICKI) were used for measurement of insulin resistance. Results Partial correlation analyses showed a significant negative correlation between circulating ghrelin and insulin level and insulin resistance in the entire cohort and also in men and women separately. The aforementioned correlation was independent of age, percentage of trunk fat and HDL-cholesterol. According to menopausal status, only pre-menopausal women revealed negative correlations. Conclusion Our results suggest that except for postmenopausal women, high circulating ghrelin level is associated with lower insulin resistance in the general population. |
format |
Article in Journal/Newspaper |
author |
Amini, Peyvand Wadden, Danny Cahill, Farrell Randell, Edward Vasdev, Sudesh Chen, Xihua Gulliver, Wayne Zhang, Weizhen Zhang, Hongwei Yi, Yanqing Sun, Guang |
author_facet |
Amini, Peyvand Wadden, Danny Cahill, Farrell Randell, Edward Vasdev, Sudesh Chen, Xihua Gulliver, Wayne Zhang, Weizhen Zhang, Hongwei Yi, Yanqing Sun, Guang |
author_sort |
Amini, Peyvand |
title |
Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study |
title_short |
Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study |
title_full |
Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study |
title_fullStr |
Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study |
title_full_unstemmed |
Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study |
title_sort |
serum acylated ghrelin is negatively correlated with the insulin resistance in the coding study |
publisher |
Public Library of Science |
publishDate |
2012 |
url |
https://research.library.mun.ca/605/ https://research.library.mun.ca/605/1/serum_acylated_ghrelin.pdf https://research.library.mun.ca/605/3/serum_acylated_ghrelin.pdf https://doi.org/10.1371/journal.pone.0045657 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
https://research.library.mun.ca/605/1/serum_acylated_ghrelin.pdf https://research.library.mun.ca/605/3/serum_acylated_ghrelin.pdf Amini, Peyvand <https://research.library.mun.ca/view/creator_az/Amini=3APeyvand=3A=3A.html> and Wadden, Danny <https://research.library.mun.ca/view/creator_az/Wadden=3ADanny=3A=3A.html> and Cahill, Farrell <https://research.library.mun.ca/view/creator_az/Cahill=3AFarrell=3A=3A.html> and Randell, Edward <https://research.library.mun.ca/view/creator_az/Randell=3AEdward=3A=3A.html> and Vasdev, Sudesh <https://research.library.mun.ca/view/creator_az/Vasdev=3ASudesh=3A=3A.html> and Chen, Xihua <https://research.library.mun.ca/view/creator_az/Chen=3AXihua=3A=3A.html> and Gulliver, Wayne <https://research.library.mun.ca/view/creator_az/Gulliver=3AWayne=3A=3A.html> and Zhang, Weizhen <https://research.library.mun.ca/view/creator_az/Zhang=3AWeizhen=3A=3A.html> and Zhang, Hongwei <https://research.library.mun.ca/view/creator_az/Zhang=3AHongwei=3A=3A.html> and Yi, Yanqing <https://research.library.mun.ca/view/creator_az/Yi=3AYanqing=3A=3A.html> and Sun, Guang <https://research.library.mun.ca/view/creator_az/Sun=3AGuang=3A=3A.html> (2012) Serum Acylated Ghrelin Is Negatively Correlated with the Insulin Resistance In the CODING study. PLoS ONE, 7 (9). pp. 1-7. ISSN 1932-6203 |
op_rights |
cc_by |
op_doi |
https://doi.org/10.1371/journal.pone.0045657 |
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