Immunoglobulin measurements in a genetic isolate
In three geographically and genetically close Newfoundland communities, there was an aggregate of 19 cases of Hodgkins disease, embryonic tumour, lymphosarcoma, leukaemia, thymoma and immunodeficiency. In this study, 939 sera from community members and control samples from 321 blood donors and healt...
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Memorial University of Newfoundland
1976
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ftmemorialuniv:oai:research.library.mun.ca:5601 2023-10-01T03:57:38+02:00 Immunoglobulin measurements in a genetic isolate Salimonu, Lekan Samusa 1976 application/pdf https://research.library.mun.ca/5601/ https://research.library.mun.ca/5601/1/Salimonu_LekanSamusa.pdf https://research.library.mun.ca/5601/3/Salimonu_LekanSamusa.pdf en eng Memorial University of Newfoundland https://research.library.mun.ca/5601/1/Salimonu_LekanSamusa.pdf https://research.library.mun.ca/5601/3/Salimonu_LekanSamusa.pdf Salimonu, Lekan Samusa <https://research.library.mun.ca/view/creator_az/Salimonu=3ALekan_Samusa=3A=3A.html> (1976) Immunoglobulin measurements in a genetic isolate. Masters thesis, Memorial University of Newfoundland. thesis_license Thesis NonPeerReviewed 1976 ftmemorialuniv 2023-09-03T06:45:24Z In three geographically and genetically close Newfoundland communities, there was an aggregate of 19 cases of Hodgkins disease, embryonic tumour, lymphosarcoma, leukaemia, thymoma and immunodeficiency. In this study, 939 sera from community members and control samples from 321 blood donors and healthy children were tested for their concentrations of immunoglobulins G, A, M and D by immunodiffusion. The results were submitted to a multifactorial analysis of variance. -- The main findings were that (i) significant differences in immunoglobulin concentrations associated with age and sex; (ii) no significant association between variations in tonsil size and the mean concentrations of the 4 immunoglobulin classes; (iii) the mean concentrations of IgG, IgA and IgM were elevated in the first and second degree relatives of the patients particularly relatives of those with embryonic tumour, lymphosarcoma, leukaemia and thymoma, and of those with immunodeficiency, and to a lesser extent in relatives of patients with Hodgkins disease; (iv) the relatives of patients with Hodgkins disease had a significantly elevated mean IgD level compared with the mean IgD levels found for other groups; (v) many relatives of the patients showed immunoglobulin deficiencies of various grades and one case each of hypogammaglobulinemia and isolated IgA deficiency. -- Elevated immunoglobulins in relatives of patients with lymphoreticular malignancies and immunodeficiencies may result from increased antigenic stimulation of the immune system, perhaps by an infective agent. A subtle form of immunodeficiency which permits the entry of antigens into these individuals more easily than in healthy people, may be a predisposing factor. It is also possible that the closely associated immunodeficiency and malignancy could both result from the same cause. The peculiar genetic make up of this community with a high incidence of inbreeding raises the possibility of an inherited disposition to both conditions. Continued exposure of the community to an ... Thesis Newfoundland Memorial University of Newfoundland: Research Repository |
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Memorial University of Newfoundland: Research Repository |
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English |
description |
In three geographically and genetically close Newfoundland communities, there was an aggregate of 19 cases of Hodgkins disease, embryonic tumour, lymphosarcoma, leukaemia, thymoma and immunodeficiency. In this study, 939 sera from community members and control samples from 321 blood donors and healthy children were tested for their concentrations of immunoglobulins G, A, M and D by immunodiffusion. The results were submitted to a multifactorial analysis of variance. -- The main findings were that (i) significant differences in immunoglobulin concentrations associated with age and sex; (ii) no significant association between variations in tonsil size and the mean concentrations of the 4 immunoglobulin classes; (iii) the mean concentrations of IgG, IgA and IgM were elevated in the first and second degree relatives of the patients particularly relatives of those with embryonic tumour, lymphosarcoma, leukaemia and thymoma, and of those with immunodeficiency, and to a lesser extent in relatives of patients with Hodgkins disease; (iv) the relatives of patients with Hodgkins disease had a significantly elevated mean IgD level compared with the mean IgD levels found for other groups; (v) many relatives of the patients showed immunoglobulin deficiencies of various grades and one case each of hypogammaglobulinemia and isolated IgA deficiency. -- Elevated immunoglobulins in relatives of patients with lymphoreticular malignancies and immunodeficiencies may result from increased antigenic stimulation of the immune system, perhaps by an infective agent. A subtle form of immunodeficiency which permits the entry of antigens into these individuals more easily than in healthy people, may be a predisposing factor. It is also possible that the closely associated immunodeficiency and malignancy could both result from the same cause. The peculiar genetic make up of this community with a high incidence of inbreeding raises the possibility of an inherited disposition to both conditions. Continued exposure of the community to an ... |
format |
Thesis |
author |
Salimonu, Lekan Samusa |
spellingShingle |
Salimonu, Lekan Samusa Immunoglobulin measurements in a genetic isolate |
author_facet |
Salimonu, Lekan Samusa |
author_sort |
Salimonu, Lekan Samusa |
title |
Immunoglobulin measurements in a genetic isolate |
title_short |
Immunoglobulin measurements in a genetic isolate |
title_full |
Immunoglobulin measurements in a genetic isolate |
title_fullStr |
Immunoglobulin measurements in a genetic isolate |
title_full_unstemmed |
Immunoglobulin measurements in a genetic isolate |
title_sort |
immunoglobulin measurements in a genetic isolate |
publisher |
Memorial University of Newfoundland |
publishDate |
1976 |
url |
https://research.library.mun.ca/5601/ https://research.library.mun.ca/5601/1/Salimonu_LekanSamusa.pdf https://research.library.mun.ca/5601/3/Salimonu_LekanSamusa.pdf |
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Newfoundland |
genre_facet |
Newfoundland |
op_relation |
https://research.library.mun.ca/5601/1/Salimonu_LekanSamusa.pdf https://research.library.mun.ca/5601/3/Salimonu_LekanSamusa.pdf Salimonu, Lekan Samusa <https://research.library.mun.ca/view/creator_az/Salimonu=3ALekan_Samusa=3A=3A.html> (1976) Immunoglobulin measurements in a genetic isolate. Masters thesis, Memorial University of Newfoundland. |
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thesis_license |
_version_ |
1778529504568803328 |