The effect of uterine septum resection on fertility and live birth rates
Objectives: To determine if patients who undergo a hysteroscopic uterine septum resection have higher live birth rates than patients with a normal hysteroscopy and unexplained infertility. Study Methods: Using surgical billing records from Newfoundland and Labrador Fertility Services, a cohort of pa...
Main Author: | |
---|---|
Format: | Thesis |
Language: | English |
Published: |
Memorial University of Newfoundland
2023
|
Subjects: | |
Online Access: | https://research.library.mun.ca/15802/ https://research.library.mun.ca/15802/3/converted.pdf |
id |
ftmemorialuniv:oai:research.library.mun.ca:15802 |
---|---|
record_format |
openpolar |
spelling |
ftmemorialuniv:oai:research.library.mun.ca:15802 2023-10-01T03:57:35+02:00 The effect of uterine septum resection on fertility and live birth rates Splinter, Karen 2023-05 application/pdf https://research.library.mun.ca/15802/ https://research.library.mun.ca/15802/3/converted.pdf en eng Memorial University of Newfoundland https://research.library.mun.ca/15802/3/converted.pdf Splinter, Karen <https://research.library.mun.ca/view/creator_az/Splinter=3AKaren=3A=3A.html> (2023) The effect of uterine septum resection on fertility and live birth rates. Masters thesis, Memorial University of Newfoundland. thesis_license Thesis NonPeerReviewed 2023 ftmemorialuniv 2023-09-03T06:50:27Z Objectives: To determine if patients who undergo a hysteroscopic uterine septum resection have higher live birth rates than patients with a normal hysteroscopy and unexplained infertility. Study Methods: Using surgical billing records from Newfoundland and Labrador Fertility Services, a cohort of patients undergoing hysteroscopic uterine septum resection from October 2003 to June 2011 were identified. The study patients were matched with the next four patients from Newfoundland and Labrador Fertility Services undergoing a diagnostic hysteroscopy who had otherwise unexplained infertility. The patients were followed from surgery for at least one year to determine if they had a pregnancy and the outcome of that pregnancy. Both groups included patients with primary infertility, secondary infertility, and recurrent pregnancy loss. The primary outcome was live birth rate, with a p value <0.05 defining statistical significance. Secondary outcomes included pregnancy rate, preterm birth rate, and markers of obstetric and neonatal morbidity; with p value <0.01 defining statistical significance. Results: A total of 50 eligible patients underwent hysteroscopic uterine septum resection (SR) during the specified timeline and were matched with 189 patients who had a diagnostic hysteroscopy (DH) for unexplained infertility. The groups were similar in age, BMI, years trying to conceive and surgeon. Univariate analysis demonstrated a significant difference in live birth rates between the groups (52.0% (SR) compared with 33.3% (DH), RR 1.56 [1.12-2.18], p=0.015). Subgroup analysis demonstrated a significant different in live birth rates between the secondary infertility group (66.7% (SR) compared with 32.4% (DH), RR 2.06 [1.22-3.47], p=0.023). Logistic regression analysis also found a higher live birth rate in the SR group (OR 2.35 [1.17-4.74], p=0.016). Postoperative pregnancy rates were higher in the SR group (72.0% compared with 41.2%, RR 1.74 (1.38-2.21), p<0.001), and this finding was confirmed by logistic regression ... Thesis Newfoundland Memorial University of Newfoundland: Research Repository Billing ENVELOPE(160.900,160.900,-75.717,-75.717) Newfoundland |
institution |
Open Polar |
collection |
Memorial University of Newfoundland: Research Repository |
op_collection_id |
ftmemorialuniv |
language |
English |
description |
Objectives: To determine if patients who undergo a hysteroscopic uterine septum resection have higher live birth rates than patients with a normal hysteroscopy and unexplained infertility. Study Methods: Using surgical billing records from Newfoundland and Labrador Fertility Services, a cohort of patients undergoing hysteroscopic uterine septum resection from October 2003 to June 2011 were identified. The study patients were matched with the next four patients from Newfoundland and Labrador Fertility Services undergoing a diagnostic hysteroscopy who had otherwise unexplained infertility. The patients were followed from surgery for at least one year to determine if they had a pregnancy and the outcome of that pregnancy. Both groups included patients with primary infertility, secondary infertility, and recurrent pregnancy loss. The primary outcome was live birth rate, with a p value <0.05 defining statistical significance. Secondary outcomes included pregnancy rate, preterm birth rate, and markers of obstetric and neonatal morbidity; with p value <0.01 defining statistical significance. Results: A total of 50 eligible patients underwent hysteroscopic uterine septum resection (SR) during the specified timeline and were matched with 189 patients who had a diagnostic hysteroscopy (DH) for unexplained infertility. The groups were similar in age, BMI, years trying to conceive and surgeon. Univariate analysis demonstrated a significant difference in live birth rates between the groups (52.0% (SR) compared with 33.3% (DH), RR 1.56 [1.12-2.18], p=0.015). Subgroup analysis demonstrated a significant different in live birth rates between the secondary infertility group (66.7% (SR) compared with 32.4% (DH), RR 2.06 [1.22-3.47], p=0.023). Logistic regression analysis also found a higher live birth rate in the SR group (OR 2.35 [1.17-4.74], p=0.016). Postoperative pregnancy rates were higher in the SR group (72.0% compared with 41.2%, RR 1.74 (1.38-2.21), p<0.001), and this finding was confirmed by logistic regression ... |
format |
Thesis |
author |
Splinter, Karen |
spellingShingle |
Splinter, Karen The effect of uterine septum resection on fertility and live birth rates |
author_facet |
Splinter, Karen |
author_sort |
Splinter, Karen |
title |
The effect of uterine septum resection on fertility and live birth rates |
title_short |
The effect of uterine septum resection on fertility and live birth rates |
title_full |
The effect of uterine septum resection on fertility and live birth rates |
title_fullStr |
The effect of uterine septum resection on fertility and live birth rates |
title_full_unstemmed |
The effect of uterine septum resection on fertility and live birth rates |
title_sort |
effect of uterine septum resection on fertility and live birth rates |
publisher |
Memorial University of Newfoundland |
publishDate |
2023 |
url |
https://research.library.mun.ca/15802/ https://research.library.mun.ca/15802/3/converted.pdf |
long_lat |
ENVELOPE(160.900,160.900,-75.717,-75.717) |
geographic |
Billing Newfoundland |
geographic_facet |
Billing Newfoundland |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
https://research.library.mun.ca/15802/3/converted.pdf Splinter, Karen <https://research.library.mun.ca/view/creator_az/Splinter=3AKaren=3A=3A.html> (2023) The effect of uterine septum resection on fertility and live birth rates. Masters thesis, Memorial University of Newfoundland. |
op_rights |
thesis_license |
_version_ |
1778529209001443328 |