The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population
Body-fat distribution is a primary risk factor for insulin resistance and cardiovascular disease. Visceral fat explains only a portion of this risk. The link between upper-body fat and insulin resistance is uncertain. Furthermore, upper-body fat is not clearly defined. Dual-energy X-ray absorptiomet...
Published in: | International Journal of Environmental Research and Public Health |
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Online Access: | https://research.library.mun.ca/15371/ https://research.library.mun.ca/15371/1/ijerph-18-05858.pdf https://doi.org/10.3390/ijerph18115858 |
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ftmemorialuniv:oai:research.library.mun.ca:15371 2023-10-01T03:57:39+02:00 The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population Youssef, Sherif Nelder, Matthew Sun, Guang 2021-05-29 application/pdf https://research.library.mun.ca/15371/ https://research.library.mun.ca/15371/1/ijerph-18-05858.pdf https://doi.org/10.3390/ijerph18115858 en eng MDPI https://research.library.mun.ca/15371/1/ijerph-18-05858.pdf Youssef, Sherif <https://research.library.mun.ca/view/creator_az/Youssef=3ASherif=3A=3A.html> and Nelder, Matthew <https://research.library.mun.ca/view/creator_az/Nelder=3AMatthew=3A=3A.html> and Sun, Guang <https://research.library.mun.ca/view/creator_az/Sun=3AGuang=3A=3A.html> (2021) The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population. International Journal of Environmental Research and Public Health, 18 (11). ISSN 1660-4601 cc_by_nc Article PeerReviewed 2021 ftmemorialuniv https://doi.org/10.3390/ijerph18115858 2023-09-03T06:50:12Z Body-fat distribution is a primary risk factor for insulin resistance and cardiovascular disease. Visceral fat explains only a portion of this risk. The link between upper-body fat and insulin resistance is uncertain. Furthermore, upper-body fat is not clearly defined. Dual-energy X-ray absorptiometry (DXA) can accurately quantify body fat. In this study, we explored the relationship between non-visceral upper-body adiposity and insulin resistance and other markers of metabolic syndrome. Fat proportions in the upper body, leg, and visceral regions were quantified by using DXA in 2547 adult Newfoundlanders aged 19 and older. Adjusting for remaining fat regions, we performed partial correlation analysis for each body region and insulin resistance defined by the Homeostatic Model of Assessment (HOMA). Similarly, partial correlation analysis was also performed between each fat region and other markers of metabolic syndrome, including high-density lipoprotein cholesterol (HDL), triglycerides (TG), body mass index (BMI), and blood pressure. Major confounding factors, including age, caloric intake, and physical activity, were statistically controlled by using partial correlation analysis. Interactions between sex, menopausal status, and medication status were also tested. Arm adiposity was correlated with HOMA-IR (R = 0.132, p < 0.001) and HOMA-β (R = 0.134, p < 0.001). Visceral adiposity was correlated with HOMA-IR (R = 0.230, p < 0.001) and HOMA-β (R = 0.160, p < 0.001). No significant correlation between non-visceral trunk adiposity and insulin resistance was found. Non-visceral trunk adiposity was negatively correlated with HDL in men (R = −0.110, p < 0.001) and women (R = −0.117, p < 0.001). Non-visceral trunk adiposity was correlated with TG (total: R = 0.079, p < 0.001; men: R = 0.105, p = 0.012; women: R = 0.078, p = 0.001). In menopausal women, leg adiposity was negatively correlated with HOMA-IR (R = −0.196, p < 0.001) and HOMA-β (R = −0.101, p = 0.012). Upper-body adiposity in the ... Article in Journal/Newspaper Newfoundland Memorial University of Newfoundland: Research Repository International Journal of Environmental Research and Public Health 18 11 5858 |
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Open Polar |
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Memorial University of Newfoundland: Research Repository |
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ftmemorialuniv |
language |
English |
description |
Body-fat distribution is a primary risk factor for insulin resistance and cardiovascular disease. Visceral fat explains only a portion of this risk. The link between upper-body fat and insulin resistance is uncertain. Furthermore, upper-body fat is not clearly defined. Dual-energy X-ray absorptiometry (DXA) can accurately quantify body fat. In this study, we explored the relationship between non-visceral upper-body adiposity and insulin resistance and other markers of metabolic syndrome. Fat proportions in the upper body, leg, and visceral regions were quantified by using DXA in 2547 adult Newfoundlanders aged 19 and older. Adjusting for remaining fat regions, we performed partial correlation analysis for each body region and insulin resistance defined by the Homeostatic Model of Assessment (HOMA). Similarly, partial correlation analysis was also performed between each fat region and other markers of metabolic syndrome, including high-density lipoprotein cholesterol (HDL), triglycerides (TG), body mass index (BMI), and blood pressure. Major confounding factors, including age, caloric intake, and physical activity, were statistically controlled by using partial correlation analysis. Interactions between sex, menopausal status, and medication status were also tested. Arm adiposity was correlated with HOMA-IR (R = 0.132, p < 0.001) and HOMA-β (R = 0.134, p < 0.001). Visceral adiposity was correlated with HOMA-IR (R = 0.230, p < 0.001) and HOMA-β (R = 0.160, p < 0.001). No significant correlation between non-visceral trunk adiposity and insulin resistance was found. Non-visceral trunk adiposity was negatively correlated with HDL in men (R = −0.110, p < 0.001) and women (R = −0.117, p < 0.001). Non-visceral trunk adiposity was correlated with TG (total: R = 0.079, p < 0.001; men: R = 0.105, p = 0.012; women: R = 0.078, p = 0.001). In menopausal women, leg adiposity was negatively correlated with HOMA-IR (R = −0.196, p < 0.001) and HOMA-β (R = −0.101, p = 0.012). Upper-body adiposity in the ... |
format |
Article in Journal/Newspaper |
author |
Youssef, Sherif Nelder, Matthew Sun, Guang |
spellingShingle |
Youssef, Sherif Nelder, Matthew Sun, Guang The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population |
author_facet |
Youssef, Sherif Nelder, Matthew Sun, Guang |
author_sort |
Youssef, Sherif |
title |
The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population |
title_short |
The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population |
title_full |
The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population |
title_fullStr |
The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population |
title_full_unstemmed |
The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population |
title_sort |
association of upper body obesity with insulin resistance in the newfoundland population |
publisher |
MDPI |
publishDate |
2021 |
url |
https://research.library.mun.ca/15371/ https://research.library.mun.ca/15371/1/ijerph-18-05858.pdf https://doi.org/10.3390/ijerph18115858 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
https://research.library.mun.ca/15371/1/ijerph-18-05858.pdf Youssef, Sherif <https://research.library.mun.ca/view/creator_az/Youssef=3ASherif=3A=3A.html> and Nelder, Matthew <https://research.library.mun.ca/view/creator_az/Nelder=3AMatthew=3A=3A.html> and Sun, Guang <https://research.library.mun.ca/view/creator_az/Sun=3AGuang=3A=3A.html> (2021) The Association of Upper Body Obesity with Insulin Resistance in the Newfoundland Population. International Journal of Environmental Research and Public Health, 18 (11). ISSN 1660-4601 |
op_rights |
cc_by_nc |
op_doi |
https://doi.org/10.3390/ijerph18115858 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
18 |
container_issue |
11 |
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5858 |
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1778529553882284032 |