Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging
Fish species exhibit great diversity rating of aging (from negligible to rapid), which gives a unique possibility for the discovery of the molecular mechanisms that determine the differences in the rate of aging. A mass spectrometric metabolic profiling of skeletal muscle of fish with various aging...
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ftmdpi:oai:mdpi.com:/2410-3888/4/2/25/ 2023-08-20T04:09:03+02:00 Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging Dmitry L. Maslov Oxana P. Trifonova Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov agris 2019-03-31 application/pdf https://doi.org/10.3390/fishes4020025 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/fishes4020025 https://creativecommons.org/licenses/by/4.0/ Fishes; Volume 4; Issue 2; Pages: 25 aging metabolome profiling muscle fish Text 2019 ftmdpi https://doi.org/10.3390/fishes4020025 2023-07-31T22:09:32Z Fish species exhibit great diversity rating of aging (from negligible to rapid), which gives a unique possibility for the discovery of the molecular mechanisms that determine the differences in the rate of aging. A mass spectrometric metabolic profiling of skeletal muscle of fish with various aging rates was carried out by direct injection to a quadrupole time-of-flight mass spectrometer. The first group includes long-lived fish species (pike (Esox Lucius) and sterlet (Acipenser ruthenus); the second group—species with gradual senescence such as that observed in many mammalian species of similar size (zander (Sandra lucioperca) and perch (Perca fluviatilis)) and the third group—species with very short life cycle (chum salmon (Oncorhynchus keta) and pink salmon (Oncorhynchus gorbuscha)). Multivariate analysis of metabolic profiles allowed the detecting of about 80 group-specific features associated with amino acids, lipids, biogenic amines, intermediates of glycolysis, glycogenolysis, and citric acid cycle. Possible roles in the aging process are hypothesized for the biochemical pathways of the metabolites that were altered in the different groups. Text Oncorhynchus gorbuscha Pink salmon MDPI Open Access Publishing Keta ENVELOPE(-19.455,-19.455,65.656,65.656) Fishes 4 2 25 |
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MDPI Open Access Publishing |
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English |
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aging metabolome profiling muscle fish |
spellingShingle |
aging metabolome profiling muscle fish Dmitry L. Maslov Oxana P. Trifonova Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
topic_facet |
aging metabolome profiling muscle fish |
description |
Fish species exhibit great diversity rating of aging (from negligible to rapid), which gives a unique possibility for the discovery of the molecular mechanisms that determine the differences in the rate of aging. A mass spectrometric metabolic profiling of skeletal muscle of fish with various aging rates was carried out by direct injection to a quadrupole time-of-flight mass spectrometer. The first group includes long-lived fish species (pike (Esox Lucius) and sterlet (Acipenser ruthenus); the second group—species with gradual senescence such as that observed in many mammalian species of similar size (zander (Sandra lucioperca) and perch (Perca fluviatilis)) and the third group—species with very short life cycle (chum salmon (Oncorhynchus keta) and pink salmon (Oncorhynchus gorbuscha)). Multivariate analysis of metabolic profiles allowed the detecting of about 80 group-specific features associated with amino acids, lipids, biogenic amines, intermediates of glycolysis, glycogenolysis, and citric acid cycle. Possible roles in the aging process are hypothesized for the biochemical pathways of the metabolites that were altered in the different groups. |
format |
Text |
author |
Dmitry L. Maslov Oxana P. Trifonova Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov |
author_facet |
Dmitry L. Maslov Oxana P. Trifonova Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov |
author_sort |
Dmitry L. Maslov |
title |
Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
title_short |
Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
title_full |
Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
title_fullStr |
Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
title_full_unstemmed |
Comparative Analysis of Skeletal Muscle Metabolites of Fish with Various Rates of Aging |
title_sort |
comparative analysis of skeletal muscle metabolites of fish with various rates of aging |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2019 |
url |
https://doi.org/10.3390/fishes4020025 |
op_coverage |
agris |
long_lat |
ENVELOPE(-19.455,-19.455,65.656,65.656) |
geographic |
Keta |
geographic_facet |
Keta |
genre |
Oncorhynchus gorbuscha Pink salmon |
genre_facet |
Oncorhynchus gorbuscha Pink salmon |
op_source |
Fishes; Volume 4; Issue 2; Pages: 25 |
op_relation |
https://dx.doi.org/10.3390/fishes4020025 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/fishes4020025 |
container_title |
Fishes |
container_volume |
4 |
container_issue |
2 |
container_start_page |
25 |
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1774721724733980672 |