Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity
After the European Food Safety Authority reviewed reports of methylmercury and heart rate variability (HRV) in 2012, the panel concluded that, although some studies of cardiac autonomy suggested an autonomic effect of methylmercury, the results were inconsistent among studies and the implications fo...
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ftmdpi:oai:mdpi.com:/2305-6304/6/3/38/ 2023-08-20T04:06:23+02:00 Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity Kanae Karita Toyoto Iwata Eri Maeda Mineshi Sakamoto Katsuyuki Murata agris 2018-07-20 application/pdf https://doi.org/10.3390/toxics6030038 EN eng Multidisciplinary Digital Publishing Institute Toxicology https://dx.doi.org/10.3390/toxics6030038 https://creativecommons.org/licenses/by/4.0/ Toxics; Volume 6; Issue 3; Pages: 38 heart rate variability methylmercury neurotoxicity review sympathodominant state Text 2018 ftmdpi https://doi.org/10.3390/toxics6030038 2023-07-31T21:38:12Z After the European Food Safety Authority reviewed reports of methylmercury and heart rate variability (HRV) in 2012, the panel concluded that, although some studies of cardiac autonomy suggested an autonomic effect of methylmercury, the results were inconsistent among studies and the implications for health were unclear. In this study, we reconsider this association by adding a perspective on the physiological context. Cardiovascular rhythmicity is usually studied within different frequency domains of HRV. Three spectral components are usually detected; in humans these are centered at <0.04 Hz, 0.15 Hz (LF), and 0.3 Hz (HF). LF and HF (sympathetic and parasympathetic activities, respectively) are evaluated in terms of frequency and power. By searching PubMed, we identified 13 studies examining the effect of methylmercury exposure on HRV in human populations in the Faroe Islands, the Seychelles and other countries. Considering both reduced HRV and sympathodominant state (i.e., lower HF, higher LF, or higher LF/HF ratio) as autonomic abnormality, eight of them showed the significant association with methylmercury exposure. Five studies failed to demonstrate any significant association. In conclusion, these data suggest that increased methylmercury exposure was consistently associated with autonomic abnormality, though the influence of methylmercury on HRV (e.g., LF) might differ for prenatal and postnatal exposures. The results with HRV should be included in the risk characterization of methylmercury. The HRV parameters calculated by frequency domain analysis appear to be more sensitive to methylmercury exposure than those by time domain analysis. Text Faroe Islands MDPI Open Access Publishing Faroe Islands Toxics 6 3 38 |
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English |
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heart rate variability methylmercury neurotoxicity review sympathodominant state |
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heart rate variability methylmercury neurotoxicity review sympathodominant state Kanae Karita Toyoto Iwata Eri Maeda Mineshi Sakamoto Katsuyuki Murata Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
topic_facet |
heart rate variability methylmercury neurotoxicity review sympathodominant state |
description |
After the European Food Safety Authority reviewed reports of methylmercury and heart rate variability (HRV) in 2012, the panel concluded that, although some studies of cardiac autonomy suggested an autonomic effect of methylmercury, the results were inconsistent among studies and the implications for health were unclear. In this study, we reconsider this association by adding a perspective on the physiological context. Cardiovascular rhythmicity is usually studied within different frequency domains of HRV. Three spectral components are usually detected; in humans these are centered at <0.04 Hz, 0.15 Hz (LF), and 0.3 Hz (HF). LF and HF (sympathetic and parasympathetic activities, respectively) are evaluated in terms of frequency and power. By searching PubMed, we identified 13 studies examining the effect of methylmercury exposure on HRV in human populations in the Faroe Islands, the Seychelles and other countries. Considering both reduced HRV and sympathodominant state (i.e., lower HF, higher LF, or higher LF/HF ratio) as autonomic abnormality, eight of them showed the significant association with methylmercury exposure. Five studies failed to demonstrate any significant association. In conclusion, these data suggest that increased methylmercury exposure was consistently associated with autonomic abnormality, though the influence of methylmercury on HRV (e.g., LF) might differ for prenatal and postnatal exposures. The results with HRV should be included in the risk characterization of methylmercury. The HRV parameters calculated by frequency domain analysis appear to be more sensitive to methylmercury exposure than those by time domain analysis. |
format |
Text |
author |
Kanae Karita Toyoto Iwata Eri Maeda Mineshi Sakamoto Katsuyuki Murata |
author_facet |
Kanae Karita Toyoto Iwata Eri Maeda Mineshi Sakamoto Katsuyuki Murata |
author_sort |
Kanae Karita |
title |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_short |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_full |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_fullStr |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_full_unstemmed |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_sort |
assessment of cardiac autonomic function in relation to methylmercury neurotoxicity |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2018 |
url |
https://doi.org/10.3390/toxics6030038 |
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agris |
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Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Toxics; Volume 6; Issue 3; Pages: 38 |
op_relation |
Toxicology https://dx.doi.org/10.3390/toxics6030038 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/toxics6030038 |
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Toxics |
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6 |
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3 |
container_start_page |
38 |
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