Dietary Oyster (Crassostrea gigas) Extract Ameliorates Dextran Sulfate Sodium-Induced Chronic Experimental Colitis by Improving the Composition of Gut Microbiota in Mice
Previously, we have reported that the intake of oyster extract (OE), prepared from Pacific oysters (Crassostrea gigas), can attenuate symptoms of dextran sulfate sodium (DSS)-induced acute experimental colitis in mice. Herein, we aimed to evaluate whether OE intake ameliorates chronic experimental c...
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ftmdpi:oai:mdpi.com:/2304-8158/11/14/2032/ 2023-08-20T04:06:01+02:00 Dietary Oyster (Crassostrea gigas) Extract Ameliorates Dextran Sulfate Sodium-Induced Chronic Experimental Colitis by Improving the Composition of Gut Microbiota in Mice Tatsuya Ishida Hiroyuki Matsui Yoshikazu Matsuda Takaki Shimono Seiji Kanda Toshimasa Nishiyama Ryota Hosomi Kenji Fukunaga Munehiro Yoshida agris 2022-07-08 application/pdf https://doi.org/10.3390/foods11142032 EN eng Multidisciplinary Digital Publishing Institute Nutraceuticals and Functional Foods https://dx.doi.org/10.3390/foods11142032 https://creativecommons.org/licenses/by/4.0/ Foods; Volume 11; Issue 14; Pages: 2032 oyster extract Pacific oysters Crassostrea gigas chronic experimental colitis microbiota short-chain fatty acid Text 2022 ftmdpi https://doi.org/10.3390/foods11142032 2023-08-01T05:39:24Z Previously, we have reported that the intake of oyster extract (OE), prepared from Pacific oysters (Crassostrea gigas), can attenuate symptoms of dextran sulfate sodium (DSS)-induced acute experimental colitis in mice. Herein, we aimed to evaluate whether OE intake ameliorates chronic experimental colitis induced by repeated DSS administration in mice. Male C57BL/6J (4-week-old) mice were fed either the standard diet AIN93G (control diet) or the control diet containing 5.0% (w/w) OE (OE diet). After 21 days of diet feeding, chronic experimental colitis was induced by three cycles of 2.0% (w/w) DSS solution administration (5 days), followed by distilled water (5 days). Mice fed OE alleviated the shortened colonic length, increased the relative weight of the spleen, colonic histopathological score (regeneration), and blood in the stool score compared with mice fed control diet. A tendency to improve the α-diversity of fecal microbiota, which was exacerbated by colitis, was observed in mice fed OE. Correlation analysis suggested that the anti-colitis effect of OE intake could be related to the valeric acid content and relative abundances of Ruminococcus and Enterococcus in the feces. In conclusion, OE could ameliorate DSS-induced chronic experimental colitis by improving the gut environment, including the microbiota community and SCFA composition. Text Crassostrea gigas MDPI Open Access Publishing Pacific Foods 11 14 2032 |
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Open Polar |
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MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
oyster extract Pacific oysters Crassostrea gigas chronic experimental colitis microbiota short-chain fatty acid |
spellingShingle |
oyster extract Pacific oysters Crassostrea gigas chronic experimental colitis microbiota short-chain fatty acid Tatsuya Ishida Hiroyuki Matsui Yoshikazu Matsuda Takaki Shimono Seiji Kanda Toshimasa Nishiyama Ryota Hosomi Kenji Fukunaga Munehiro Yoshida Dietary Oyster (Crassostrea gigas) Extract Ameliorates Dextran Sulfate Sodium-Induced Chronic Experimental Colitis by Improving the Composition of Gut Microbiota in Mice |
topic_facet |
oyster extract Pacific oysters Crassostrea gigas chronic experimental colitis microbiota short-chain fatty acid |
description |
Previously, we have reported that the intake of oyster extract (OE), prepared from Pacific oysters (Crassostrea gigas), can attenuate symptoms of dextran sulfate sodium (DSS)-induced acute experimental colitis in mice. Herein, we aimed to evaluate whether OE intake ameliorates chronic experimental colitis induced by repeated DSS administration in mice. Male C57BL/6J (4-week-old) mice were fed either the standard diet AIN93G (control diet) or the control diet containing 5.0% (w/w) OE (OE diet). After 21 days of diet feeding, chronic experimental colitis was induced by three cycles of 2.0% (w/w) DSS solution administration (5 days), followed by distilled water (5 days). Mice fed OE alleviated the shortened colonic length, increased the relative weight of the spleen, colonic histopathological score (regeneration), and blood in the stool score compared with mice fed control diet. A tendency to improve the α-diversity of fecal microbiota, which was exacerbated by colitis, was observed in mice fed OE. Correlation analysis suggested that the anti-colitis effect of OE intake could be related to the valeric acid content and relative abundances of Ruminococcus and Enterococcus in the feces. In conclusion, OE could ameliorate DSS-induced chronic experimental colitis by improving the gut environment, including the microbiota community and SCFA composition. |
format |
Text |
author |
Tatsuya Ishida Hiroyuki Matsui Yoshikazu Matsuda Takaki Shimono Seiji Kanda Toshimasa Nishiyama Ryota Hosomi Kenji Fukunaga Munehiro Yoshida |
author_facet |
Tatsuya Ishida Hiroyuki Matsui Yoshikazu Matsuda Takaki Shimono Seiji Kanda Toshimasa Nishiyama Ryota Hosomi Kenji Fukunaga Munehiro Yoshida |
author_sort |
Tatsuya Ishida |
title |
Dietary Oyster (Crassostrea gigas) Extract Ameliorates Dextran Sulfate Sodium-Induced Chronic Experimental Colitis by Improving the Composition of Gut Microbiota in Mice |
title_short |
Dietary Oyster (Crassostrea gigas) Extract Ameliorates Dextran Sulfate Sodium-Induced Chronic Experimental Colitis by Improving the Composition of Gut Microbiota in Mice |
title_full |
Dietary Oyster (Crassostrea gigas) Extract Ameliorates Dextran Sulfate Sodium-Induced Chronic Experimental Colitis by Improving the Composition of Gut Microbiota in Mice |
title_fullStr |
Dietary Oyster (Crassostrea gigas) Extract Ameliorates Dextran Sulfate Sodium-Induced Chronic Experimental Colitis by Improving the Composition of Gut Microbiota in Mice |
title_full_unstemmed |
Dietary Oyster (Crassostrea gigas) Extract Ameliorates Dextran Sulfate Sodium-Induced Chronic Experimental Colitis by Improving the Composition of Gut Microbiota in Mice |
title_sort |
dietary oyster (crassostrea gigas) extract ameliorates dextran sulfate sodium-induced chronic experimental colitis by improving the composition of gut microbiota in mice |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/foods11142032 |
op_coverage |
agris |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
Foods; Volume 11; Issue 14; Pages: 2032 |
op_relation |
Nutraceuticals and Functional Foods https://dx.doi.org/10.3390/foods11142032 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/foods11142032 |
container_title |
Foods |
container_volume |
11 |
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14 |
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2032 |
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1774716922941669376 |