One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization?
(1) Background: After spending a year wintering in Antarctica, individual expedition members have reported increased or even new allergic reactions to environmental allergens after their return. (2) Methods: Blood samples from five overwintering crews were analyzed using the chip based multiplex ALE...
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ftmdpi:oai:mdpi.com:/2227-9059/10/2/448/ 2023-08-20T04:01:48+02:00 One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization? Matthias Feuerecker Claudia Strewe Martina Aumayr Tim Heitland Ulrich Limper Brian Crucian Sarah Baatout Alexander Choukér 2022-02-15 application/pdf https://doi.org/10.3390/biomedicines10020448 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/biomedicines10020448 https://creativecommons.org/licenses/by/4.0/ Biomedicines; Volume 10; Issue 2; Pages: 448 Antarctica space mission like confinement allergy chip-based multiplex assay sensitization immune system Text 2022 ftmdpi https://doi.org/10.3390/biomedicines10020448 2023-08-01T04:10:01Z (1) Background: After spending a year wintering in Antarctica, individual expedition members have reported increased or even new allergic reactions to environmental allergens after their return. (2) Methods: Blood samples from five overwintering crews were analyzed using the chip based multiplex ALEX Allergy Explorer (MacroArray Diagnostics GmbH, Austria). (3) Results: About one third of the 39 participants displayed specific IgEs against pollen. In most individuals, kinetics showed a reduction in the specific IgE at the time about nine months after deployment to Antarctica. Five participants had the highest specific IgE levels after returning to the “normal” world. The examination of the specific IgE relative to house dust mites and storage mites showed different kinetics. Six out of 10 had the highest specific IgE concentrations at the inner Antarctic measurement time point. These data corresponded well to the general situation in the stations. At the stations themselves, there were almost no pollen particle load, especially at Concordia. (4) Conclusions: Antarctic long-term confinement can induce an altered immune function, which is in some individuals pronounced after return to the familiar allergen environment. Future prospective studies in larger cohorts are needed to further specify these first results. Text Antarc* Antarctic Antarctica MDPI Open Access Publishing Antarctic Biomedicines 10 2 448 |
institution |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
Antarctica space mission like confinement allergy chip-based multiplex assay sensitization immune system |
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Antarctica space mission like confinement allergy chip-based multiplex assay sensitization immune system Matthias Feuerecker Claudia Strewe Martina Aumayr Tim Heitland Ulrich Limper Brian Crucian Sarah Baatout Alexander Choukér One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization? |
topic_facet |
Antarctica space mission like confinement allergy chip-based multiplex assay sensitization immune system |
description |
(1) Background: After spending a year wintering in Antarctica, individual expedition members have reported increased or even new allergic reactions to environmental allergens after their return. (2) Methods: Blood samples from five overwintering crews were analyzed using the chip based multiplex ALEX Allergy Explorer (MacroArray Diagnostics GmbH, Austria). (3) Results: About one third of the 39 participants displayed specific IgEs against pollen. In most individuals, kinetics showed a reduction in the specific IgE at the time about nine months after deployment to Antarctica. Five participants had the highest specific IgE levels after returning to the “normal” world. The examination of the specific IgE relative to house dust mites and storage mites showed different kinetics. Six out of 10 had the highest specific IgE concentrations at the inner Antarctic measurement time point. These data corresponded well to the general situation in the stations. At the stations themselves, there were almost no pollen particle load, especially at Concordia. (4) Conclusions: Antarctic long-term confinement can induce an altered immune function, which is in some individuals pronounced after return to the familiar allergen environment. Future prospective studies in larger cohorts are needed to further specify these first results. |
format |
Text |
author |
Matthias Feuerecker Claudia Strewe Martina Aumayr Tim Heitland Ulrich Limper Brian Crucian Sarah Baatout Alexander Choukér |
author_facet |
Matthias Feuerecker Claudia Strewe Martina Aumayr Tim Heitland Ulrich Limper Brian Crucian Sarah Baatout Alexander Choukér |
author_sort |
Matthias Feuerecker |
title |
One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization? |
title_short |
One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization? |
title_full |
One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization? |
title_fullStr |
One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization? |
title_full_unstemmed |
One Year in the Extreme Isolation of Antarctica—Is This Enough to Modulate an “Allergic” Sensitization? |
title_sort |
one year in the extreme isolation of antarctica—is this enough to modulate an “allergic” sensitization? |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/biomedicines10020448 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctica |
genre_facet |
Antarc* Antarctic Antarctica |
op_source |
Biomedicines; Volume 10; Issue 2; Pages: 448 |
op_relation |
https://dx.doi.org/10.3390/biomedicines10020448 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/biomedicines10020448 |
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Biomedicines |
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10 |
container_issue |
2 |
container_start_page |
448 |
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1774725012816658432 |