High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices
Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon (Salmo salar) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat (Sprattus sprattus) and herring (Clupea harengus). The concentration of n−3 polyunsa...
Published in: | Biomolecules |
---|---|
Main Authors: | , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute
2022
|
Subjects: | |
Online Access: | https://doi.org/10.3390/biom12040526 |
id |
ftmdpi:oai:mdpi.com:/2218-273X/12/4/526/ |
---|---|
record_format |
openpolar |
spelling |
ftmdpi:oai:mdpi.com:/2218-273X/12/4/526/ 2023-08-20T04:05:17+02:00 High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices Marja Keinänen Soili Nikonen Reijo Käkelä Tiina Ritvanen Mervi Rokka Timo Myllylä Jukka Pönni Pekka J. Vuorinen agris 2022-03-30 application/pdf https://doi.org/10.3390/biom12040526 EN eng Multidisciplinary Digital Publishing Institute Biological Factors https://dx.doi.org/10.3390/biom12040526 https://creativecommons.org/licenses/by/4.0/ Biomolecules; Volume 12; Issue 4; Pages: 526 Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde polyunsaturated fatty acids sprat Sprattus sprattus thiamine total lipids Text 2022 ftmdpi https://doi.org/10.3390/biom12040526 2023-08-01T04:37:00Z Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon (Salmo salar) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat (Sprattus sprattus) and herring (Clupea harengus). The concentration of n−3 polyunsaturated fatty acids (n−3 PUFAs) increased in salmon with dietary lipids and n−3 PUFAs, and the hepatic peroxidation product malondialdehyde (MDA) concentration increased exponentially with increasing n−3 PUFA and docosahexaenoic acid (DHA, 22:6n−3) concentration, whereas hepatic total thiamine concentration, a sensitive indicator of thiamine status, decreased with the increase in both body lipid and n−3 PUFA or DHA concentration. The hepatic glucose 6-phosphate dehydrogenase activity was suppressed by high dietary lipids. In salmon muscle and in prey fish, the proportion of thiamine pyrophosphate increased, and that of free thiamine decreased, with increasing body lipid content or PUFAs, or merely DHA. The thiamine status of salmon was impaired mainly due to the peroxidation of n−3 PUFAs, whereas lipids as a source of metabolic energy had less effect. Organochlorines or general oxidative stress did not affect the thiamine status. The amount of lipids, and, specifically, their long-chain n−3 PUFAs, are thus responsible for generating thiamine deficiency, and not a prey fish species per se. Text Atlantic salmon Salmo salar MDPI Open Access Publishing Biomolecules 12 4 526 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde polyunsaturated fatty acids sprat Sprattus sprattus thiamine total lipids |
spellingShingle |
Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde polyunsaturated fatty acids sprat Sprattus sprattus thiamine total lipids Marja Keinänen Soili Nikonen Reijo Käkelä Tiina Ritvanen Mervi Rokka Timo Myllylä Jukka Pönni Pekka J. Vuorinen High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
topic_facet |
Atlantic salmon Salmo salar Baltic Sea herring Clupea harengus lipid peroxidation M74 syndrome malondialdehyde polyunsaturated fatty acids sprat Sprattus sprattus thiamine total lipids |
description |
Signs of impaired thiamine (vitamin B1) status in feeding-migrating Atlantic salmon (Salmo salar) were studied in three Baltic Sea areas, which differ in the proportion and nutritional composition of prey fish sprat (Sprattus sprattus) and herring (Clupea harengus). The concentration of n−3 polyunsaturated fatty acids (n−3 PUFAs) increased in salmon with dietary lipids and n−3 PUFAs, and the hepatic peroxidation product malondialdehyde (MDA) concentration increased exponentially with increasing n−3 PUFA and docosahexaenoic acid (DHA, 22:6n−3) concentration, whereas hepatic total thiamine concentration, a sensitive indicator of thiamine status, decreased with the increase in both body lipid and n−3 PUFA or DHA concentration. The hepatic glucose 6-phosphate dehydrogenase activity was suppressed by high dietary lipids. In salmon muscle and in prey fish, the proportion of thiamine pyrophosphate increased, and that of free thiamine decreased, with increasing body lipid content or PUFAs, or merely DHA. The thiamine status of salmon was impaired mainly due to the peroxidation of n−3 PUFAs, whereas lipids as a source of metabolic energy had less effect. Organochlorines or general oxidative stress did not affect the thiamine status. The amount of lipids, and, specifically, their long-chain n−3 PUFAs, are thus responsible for generating thiamine deficiency, and not a prey fish species per se. |
format |
Text |
author |
Marja Keinänen Soili Nikonen Reijo Käkelä Tiina Ritvanen Mervi Rokka Timo Myllylä Jukka Pönni Pekka J. Vuorinen |
author_facet |
Marja Keinänen Soili Nikonen Reijo Käkelä Tiina Ritvanen Mervi Rokka Timo Myllylä Jukka Pönni Pekka J. Vuorinen |
author_sort |
Marja Keinänen |
title |
High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
title_short |
High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
title_full |
High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
title_fullStr |
High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
title_full_unstemmed |
High Lipid Content of Prey Fish and n−3 PUFA Peroxidation Impair the Thiamine Status of Feeding-Migrating Atlantic Salmon (Salmo salar) and Is Reflected in Hepatic Biochemical Indices |
title_sort |
high lipid content of prey fish and n−3 pufa peroxidation impair the thiamine status of feeding-migrating atlantic salmon (salmo salar) and is reflected in hepatic biochemical indices |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/biom12040526 |
op_coverage |
agris |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Biomolecules; Volume 12; Issue 4; Pages: 526 |
op_relation |
Biological Factors https://dx.doi.org/10.3390/biom12040526 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/biom12040526 |
container_title |
Biomolecules |
container_volume |
12 |
container_issue |
4 |
container_start_page |
526 |
_version_ |
1774715766451470336 |