Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity
Universal hepatitis B vaccination of newborns was implemented in Russia starting from 1998. From 1998 to 2019, the incidence of acute hepatitis B reduced from 43.8 to 0.57 cases per 100,000 population. Here, we assessed the timely coverage of newborns with the birth dose (HepB-BD), second dose (HepB...
Published in: | Vaccines |
---|---|
Main Authors: | , , , , , , , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute
2021
|
Subjects: | |
Online Access: | https://doi.org/10.3390/vaccines9020082 |
id |
ftmdpi:oai:mdpi.com:/2076-393X/9/2/82/ |
---|---|
record_format |
openpolar |
spelling |
ftmdpi:oai:mdpi.com:/2076-393X/9/2/82/ 2023-08-20T04:10:20+02:00 Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity Karen K. Kyuregyan Vera S. Kichatova Olga V. Isaeva Ilya A. Potemkin Elena Yu. Malinnikova Maria A. Lopatukhina Anastasia A. Karlsen Fedor A. Asadi Mobarhan Eugeniy V. Mullin Olga S. Slukinova Margarita E. Ignateva Snezhana S. Sleptsova Elena E. Oglezneva Elena V. Shibrik Maria G. Isaguliants Mikhail I. Mikhailov 2021-01-23 application/pdf https://doi.org/10.3390/vaccines9020082 EN eng Multidisciplinary Digital Publishing Institute Hepatitis Virus Vaccines https://dx.doi.org/10.3390/vaccines9020082 https://creativecommons.org/licenses/by/4.0/ Vaccines; Volume 9; Issue 2; Pages: 82 hepatitis B vaccine birth dose coverage HBV prevalence hepatitis B epidemiology public health Text 2021 ftmdpi https://doi.org/10.3390/vaccines9020082 2023-08-01T00:55:38Z Universal hepatitis B vaccination of newborns was implemented in Russia starting from 1998. From 1998 to 2019, the incidence of acute hepatitis B reduced from 43.8 to 0.57 cases per 100,000 population. Here, we assessed the timely coverage of newborns with the birth dose (HepB-BD), second dose (HepB-2nd), and three vaccine doses (HepB3) in two remote regions of Russia with low (Belgorod Oblast) and high (Yakutia) levels of hepatitis B virus (HBV) endemicity. Vaccination data were obtained from the medical records of 1000 children in Yakutia and 2182 children in Belgorod Oblast. Sera of healthy volunteers from Belgorod Oblast (n = 1754) and Yakutia (n = 1072) across all age groups were tested for serological markers of HBV to assess the infection prevalence and herd immunity. Average HepB-BD coverage was 99.2% in Yakutia and 89.4% in Belgorod Oblast (p < 0.0001) and in both regions varied significantly, from 66% to 100%, between medical centers. The principal reason for the absence of HepB-BD was parent refusal, which accounted for 63.5% of cases of non-vaccination (83/123). While timely HepB-2nd coverage was only 55.4%–64.7%: HepB3 coverage by the age of one year exceeded 90% in both study regions. HBV surface antigen (HBsAg) prevalence in the 1998–2019 birth cohort was 0.2% (95% CI: 0.01–1.3%) in Belgorod Oblast and 3.2% (95% CI: 1.9–5.2%) in Yakutia. The proportion of persons testing negative for both antibodies to HBsAg (anti-HBs) and antibodies to HBV core antigen (anti-HBc) in the 1998–2019 birth cohort was 26.2% (125/481) in Belgorod Oblast and 32.3% (162/501) in Yakutia. We also assessed the knowledge of and attitude towards vaccination among 782 students and teachers of both medical and non-medical specialties from Belgorod State University. Only 60% of medical students knew that hepatitis B is a vaccine-preventable disease. Both medical and nonmedical students, 37.8% and 31.3%, respectively, expressed concerns about safety and actual necessity of vaccination. These data indicate the need to introduce ... Text Yakutia MDPI Open Access Publishing Vaccines 9 2 82 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
hepatitis B vaccine birth dose coverage HBV prevalence hepatitis B epidemiology public health |
spellingShingle |
hepatitis B vaccine birth dose coverage HBV prevalence hepatitis B epidemiology public health Karen K. Kyuregyan Vera S. Kichatova Olga V. Isaeva Ilya A. Potemkin Elena Yu. Malinnikova Maria A. Lopatukhina Anastasia A. Karlsen Fedor A. Asadi Mobarhan Eugeniy V. Mullin Olga S. Slukinova Margarita E. Ignateva Snezhana S. Sleptsova Elena E. Oglezneva Elena V. Shibrik Maria G. Isaguliants Mikhail I. Mikhailov Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity |
topic_facet |
hepatitis B vaccine birth dose coverage HBV prevalence hepatitis B epidemiology public health |
description |
Universal hepatitis B vaccination of newborns was implemented in Russia starting from 1998. From 1998 to 2019, the incidence of acute hepatitis B reduced from 43.8 to 0.57 cases per 100,000 population. Here, we assessed the timely coverage of newborns with the birth dose (HepB-BD), second dose (HepB-2nd), and three vaccine doses (HepB3) in two remote regions of Russia with low (Belgorod Oblast) and high (Yakutia) levels of hepatitis B virus (HBV) endemicity. Vaccination data were obtained from the medical records of 1000 children in Yakutia and 2182 children in Belgorod Oblast. Sera of healthy volunteers from Belgorod Oblast (n = 1754) and Yakutia (n = 1072) across all age groups were tested for serological markers of HBV to assess the infection prevalence and herd immunity. Average HepB-BD coverage was 99.2% in Yakutia and 89.4% in Belgorod Oblast (p < 0.0001) and in both regions varied significantly, from 66% to 100%, between medical centers. The principal reason for the absence of HepB-BD was parent refusal, which accounted for 63.5% of cases of non-vaccination (83/123). While timely HepB-2nd coverage was only 55.4%–64.7%: HepB3 coverage by the age of one year exceeded 90% in both study regions. HBV surface antigen (HBsAg) prevalence in the 1998–2019 birth cohort was 0.2% (95% CI: 0.01–1.3%) in Belgorod Oblast and 3.2% (95% CI: 1.9–5.2%) in Yakutia. The proportion of persons testing negative for both antibodies to HBsAg (anti-HBs) and antibodies to HBV core antigen (anti-HBc) in the 1998–2019 birth cohort was 26.2% (125/481) in Belgorod Oblast and 32.3% (162/501) in Yakutia. We also assessed the knowledge of and attitude towards vaccination among 782 students and teachers of both medical and non-medical specialties from Belgorod State University. Only 60% of medical students knew that hepatitis B is a vaccine-preventable disease. Both medical and nonmedical students, 37.8% and 31.3%, respectively, expressed concerns about safety and actual necessity of vaccination. These data indicate the need to introduce ... |
format |
Text |
author |
Karen K. Kyuregyan Vera S. Kichatova Olga V. Isaeva Ilya A. Potemkin Elena Yu. Malinnikova Maria A. Lopatukhina Anastasia A. Karlsen Fedor A. Asadi Mobarhan Eugeniy V. Mullin Olga S. Slukinova Margarita E. Ignateva Snezhana S. Sleptsova Elena E. Oglezneva Elena V. Shibrik Maria G. Isaguliants Mikhail I. Mikhailov |
author_facet |
Karen K. Kyuregyan Vera S. Kichatova Olga V. Isaeva Ilya A. Potemkin Elena Yu. Malinnikova Maria A. Lopatukhina Anastasia A. Karlsen Fedor A. Asadi Mobarhan Eugeniy V. Mullin Olga S. Slukinova Margarita E. Ignateva Snezhana S. Sleptsova Elena E. Oglezneva Elena V. Shibrik Maria G. Isaguliants Mikhail I. Mikhailov |
author_sort |
Karen K. Kyuregyan |
title |
Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity |
title_short |
Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity |
title_full |
Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity |
title_fullStr |
Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity |
title_full_unstemmed |
Coverage with Timely Administered Vaccination against Hepatitis B Virus and Its Influence on the Prevalence of HBV Infection in the Regions of Different Endemicity |
title_sort |
coverage with timely administered vaccination against hepatitis b virus and its influence on the prevalence of hbv infection in the regions of different endemicity |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/vaccines9020082 |
genre |
Yakutia |
genre_facet |
Yakutia |
op_source |
Vaccines; Volume 9; Issue 2; Pages: 82 |
op_relation |
Hepatitis Virus Vaccines https://dx.doi.org/10.3390/vaccines9020082 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/vaccines9020082 |
container_title |
Vaccines |
container_volume |
9 |
container_issue |
2 |
container_start_page |
82 |
_version_ |
1774724450849128448 |