Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats
This study evaluated the protective effects of Dendropanax morbifera leaf (DML) extracts in the liver due to excessive ethanol consumption. Our results showed that the ethanol extract had better antioxidant activity than the water extract, likely due to the higher levels of total flavonoid and pheno...
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ftmdpi:oai:mdpi.com:/2076-3921/9/10/911/ 2023-08-20T04:06:09+02:00 Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats Taekil Eom Gwangpyo Ko Kyeoung Cheol Kim Ju-Sung Kim Tatsuya Unno agris 2020-09-24 application/pdf https://doi.org/10.3390/antiox9100911 EN eng Multidisciplinary Digital Publishing Institute Health Outcomes of Antioxidants and Oxidative Stress https://dx.doi.org/10.3390/antiox9100911 https://creativecommons.org/licenses/by/4.0/ Antioxidants; Volume 9; Issue 10; Pages: 911 Dendropanax morbifera hepatoprotective leaf extract liver damage alcoholism oxidative damage Text 2020 ftmdpi https://doi.org/10.3390/antiox9100911 2023-08-01T00:10:08Z This study evaluated the protective effects of Dendropanax morbifera leaf (DML) extracts in the liver due to excessive ethanol consumption. Our results showed that the ethanol extract had better antioxidant activity than the water extract, likely due to the higher levels of total flavonoid and phenolic compounds in the former. We found that the main phenolic acid was chlorogenic acid and the major flavonoid was rutin. Results from the animal model experiment showed concentration-dependent liver protection with the distilled water extract showing better liver protection than the ethanol extract. Gut microbiota dysbiosis induced by alcohol consumption was significantly shifted by DML extracts through increasing mainly Bacteroides and Allobaculum. Moreover, predicted metabolic activities of biosynthesis of beneficial monounsaturated fatty acids such as oleate and palmitoleate were enhanced. Our results suggest that these hepatoprotective effects are likely due to the increased activities of antioxidant enzymes and partially promoted by intestinal microbiota shifts. Text DML MDPI Open Access Publishing Antioxidants 9 10 911 |
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MDPI Open Access Publishing |
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ftmdpi |
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English |
topic |
Dendropanax morbifera hepatoprotective leaf extract liver damage alcoholism oxidative damage |
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Dendropanax morbifera hepatoprotective leaf extract liver damage alcoholism oxidative damage Taekil Eom Gwangpyo Ko Kyeoung Cheol Kim Ju-Sung Kim Tatsuya Unno Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats |
topic_facet |
Dendropanax morbifera hepatoprotective leaf extract liver damage alcoholism oxidative damage |
description |
This study evaluated the protective effects of Dendropanax morbifera leaf (DML) extracts in the liver due to excessive ethanol consumption. Our results showed that the ethanol extract had better antioxidant activity than the water extract, likely due to the higher levels of total flavonoid and phenolic compounds in the former. We found that the main phenolic acid was chlorogenic acid and the major flavonoid was rutin. Results from the animal model experiment showed concentration-dependent liver protection with the distilled water extract showing better liver protection than the ethanol extract. Gut microbiota dysbiosis induced by alcohol consumption was significantly shifted by DML extracts through increasing mainly Bacteroides and Allobaculum. Moreover, predicted metabolic activities of biosynthesis of beneficial monounsaturated fatty acids such as oleate and palmitoleate were enhanced. Our results suggest that these hepatoprotective effects are likely due to the increased activities of antioxidant enzymes and partially promoted by intestinal microbiota shifts. |
format |
Text |
author |
Taekil Eom Gwangpyo Ko Kyeoung Cheol Kim Ju-Sung Kim Tatsuya Unno |
author_facet |
Taekil Eom Gwangpyo Ko Kyeoung Cheol Kim Ju-Sung Kim Tatsuya Unno |
author_sort |
Taekil Eom |
title |
Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats |
title_short |
Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats |
title_full |
Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats |
title_fullStr |
Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats |
title_full_unstemmed |
Dendropanax morbifera Leaf Extracts Improved Alcohol Liver Injury in Association with Changes in the Gut Microbiota of Rats |
title_sort |
dendropanax morbifera leaf extracts improved alcohol liver injury in association with changes in the gut microbiota of rats |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2020 |
url |
https://doi.org/10.3390/antiox9100911 |
op_coverage |
agris |
genre |
DML |
genre_facet |
DML |
op_source |
Antioxidants; Volume 9; Issue 10; Pages: 911 |
op_relation |
Health Outcomes of Antioxidants and Oxidative Stress https://dx.doi.org/10.3390/antiox9100911 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/antiox9100911 |
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Antioxidants |
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911 |
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