Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos)
Oxidative stress, which is believed to promote muscle atrophy, has been reported to occur in a few hibernators. However, hibernating bears exhibit efficient energy savings and muscle protein sparing, despite long-term physical inactivity and fasting. We hypothesized that the regulation of the oxidan...
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ftmdpi:oai:mdpi.com:/2076-3921/8/9/334/ 2023-08-20T04:10:17+02:00 Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) Blandine Chazarin Anna Ziemianin Alina L. Evans Emmanuelle Meugnier Emmanuelle Loizon Isabelle Chery Jon M. Arnemo Jon E. Swenson Guillemette Gauquelin-Koch Chantal Simon Stéphane Blanc Etienne Lefai Fabrice Bertile agris 2019-08-22 application/pdf https://doi.org/10.3390/antiox8090334 EN eng Multidisciplinary Digital Publishing Institute Health Outcomes of Antioxidants and Oxidative Stress https://dx.doi.org/10.3390/antiox8090334 https://creativecommons.org/licenses/by/4.0/ Antioxidants; Volume 8; Issue 9; Pages: 334 hibernation brown bears skeletal muscle cold response oxidative stress NRF2 Text 2019 ftmdpi https://doi.org/10.3390/antiox8090334 2023-07-31T22:32:37Z Oxidative stress, which is believed to promote muscle atrophy, has been reported to occur in a few hibernators. However, hibernating bears exhibit efficient energy savings and muscle protein sparing, despite long-term physical inactivity and fasting. We hypothesized that the regulation of the oxidant/antioxidant balance and oxidative stress could favor skeletal muscle maintenance in hibernating brown bears. We showed that increased expressions of cold-inducible proteins CIRBP and RBM3 could favor muscle mass maintenance and alleviate oxidative stress during hibernation. Downregulation of the subunits of the mitochondrial electron transfer chain complexes I, II, and III, and antioxidant enzymes, possibly due to the reduced mitochondrial content, indicated a possible reduction of the production of reactive oxygen species in the hibernating muscle. Concomitantly, the upregulation of cytosolic antioxidant systems, under the control of the transcription factor NRF2, and the maintenance of the GSH/GSSG ratio suggested that bear skeletal muscle is not under a significant oxidative insult during hibernation. Accordingly, lower levels of oxidative damage were recorded in hibernating bear skeletal muscles. These results identify mechanisms by which limited oxidative stress may underlie the resistance to skeletal muscle atrophy in hibernating brown bears. They may constitute therapeutic targets for the treatment of human muscle atrophy. Text Ursus arctos MDPI Open Access Publishing Antioxidants 8 9 334 |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
hibernation brown bears skeletal muscle cold response oxidative stress NRF2 |
spellingShingle |
hibernation brown bears skeletal muscle cold response oxidative stress NRF2 Blandine Chazarin Anna Ziemianin Alina L. Evans Emmanuelle Meugnier Emmanuelle Loizon Isabelle Chery Jon M. Arnemo Jon E. Swenson Guillemette Gauquelin-Koch Chantal Simon Stéphane Blanc Etienne Lefai Fabrice Bertile Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
topic_facet |
hibernation brown bears skeletal muscle cold response oxidative stress NRF2 |
description |
Oxidative stress, which is believed to promote muscle atrophy, has been reported to occur in a few hibernators. However, hibernating bears exhibit efficient energy savings and muscle protein sparing, despite long-term physical inactivity and fasting. We hypothesized that the regulation of the oxidant/antioxidant balance and oxidative stress could favor skeletal muscle maintenance in hibernating brown bears. We showed that increased expressions of cold-inducible proteins CIRBP and RBM3 could favor muscle mass maintenance and alleviate oxidative stress during hibernation. Downregulation of the subunits of the mitochondrial electron transfer chain complexes I, II, and III, and antioxidant enzymes, possibly due to the reduced mitochondrial content, indicated a possible reduction of the production of reactive oxygen species in the hibernating muscle. Concomitantly, the upregulation of cytosolic antioxidant systems, under the control of the transcription factor NRF2, and the maintenance of the GSH/GSSG ratio suggested that bear skeletal muscle is not under a significant oxidative insult during hibernation. Accordingly, lower levels of oxidative damage were recorded in hibernating bear skeletal muscles. These results identify mechanisms by which limited oxidative stress may underlie the resistance to skeletal muscle atrophy in hibernating brown bears. They may constitute therapeutic targets for the treatment of human muscle atrophy. |
format |
Text |
author |
Blandine Chazarin Anna Ziemianin Alina L. Evans Emmanuelle Meugnier Emmanuelle Loizon Isabelle Chery Jon M. Arnemo Jon E. Swenson Guillemette Gauquelin-Koch Chantal Simon Stéphane Blanc Etienne Lefai Fabrice Bertile |
author_facet |
Blandine Chazarin Anna Ziemianin Alina L. Evans Emmanuelle Meugnier Emmanuelle Loizon Isabelle Chery Jon M. Arnemo Jon E. Swenson Guillemette Gauquelin-Koch Chantal Simon Stéphane Blanc Etienne Lefai Fabrice Bertile |
author_sort |
Blandine Chazarin |
title |
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
title_short |
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
title_full |
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
title_fullStr |
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
title_full_unstemmed |
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
title_sort |
limited oxidative stress favors resistance to skeletal muscle atrophy in hibernating brown bears (ursus arctos) |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2019 |
url |
https://doi.org/10.3390/antiox8090334 |
op_coverage |
agris |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
Antioxidants; Volume 8; Issue 9; Pages: 334 |
op_relation |
Health Outcomes of Antioxidants and Oxidative Stress https://dx.doi.org/10.3390/antiox8090334 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/antiox8090334 |
container_title |
Antioxidants |
container_volume |
8 |
container_issue |
9 |
container_start_page |
334 |
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1774724355616407552 |