Nitric Oxide Production and Regulation in the Teleost Cardiovascular System
Nitric Oxide (NO) is a free radical with numerous critical signaling roles in vertebrate physiology. Similar to mammals, in the teleost system the generation of sufficient amounts of NO is critical for the physiological function of the cardiovascular system. At the same time, NO amounts are strictly...
Published in: | Antioxidants |
---|---|
Main Authors: | , , |
Format: | Text |
Language: | English |
Published: |
Multidisciplinary Digital Publishing Institute
2022
|
Subjects: | |
Online Access: | https://doi.org/10.3390/antiox11050957 |
id |
ftmdpi:oai:mdpi.com:/2076-3921/11/5/957/ |
---|---|
record_format |
openpolar |
spelling |
ftmdpi:oai:mdpi.com:/2076-3921/11/5/957/ 2023-08-20T04:01:35+02:00 Nitric Oxide Production and Regulation in the Teleost Cardiovascular System Daniela Giordano Cinzia Verde Paola Corti agris 2022-05-12 application/pdf https://doi.org/10.3390/antiox11050957 EN eng Multidisciplinary Digital Publishing Institute ROS, RNS and RSS https://dx.doi.org/10.3390/antiox11050957 https://creativecommons.org/licenses/by/4.0/ Antioxidants; Volume 11; Issue 5; Pages: 957 nitric oxide synthase Antarctic fish hemoglobin myoglobin neuroglobin cytoglobin globin X nitrite reductase S -nitrosylation Text 2022 ftmdpi https://doi.org/10.3390/antiox11050957 2023-08-01T05:01:46Z Nitric Oxide (NO) is a free radical with numerous critical signaling roles in vertebrate physiology. Similar to mammals, in the teleost system the generation of sufficient amounts of NO is critical for the physiological function of the cardiovascular system. At the same time, NO amounts are strictly controlled and kept within basal levels to protect cells from NO toxicity. Changes in oxygen tension highly influence NO bioavailability and can modulate the mechanisms involved in maintaining the NO balance. While NO production and signaling appears to have general similarities with mammalian systems, the wide range of environmental adaptations made by fish, particularly with regards to differing oxygen availabilities in aquatic habitats, creates a foundation for a variety of in vivo models characterized by different implications of NO production and signaling. In this review, we present the biology of NO in the teleost cardiovascular system and summarize the mechanisms of NO production and signaling with a special emphasis on the role of globin proteins in NO metabolism. Text Antarc* Antarctic MDPI Open Access Publishing Antarctic Antioxidants 11 5 957 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
nitric oxide synthase Antarctic fish hemoglobin myoglobin neuroglobin cytoglobin globin X nitrite reductase S -nitrosylation |
spellingShingle |
nitric oxide synthase Antarctic fish hemoglobin myoglobin neuroglobin cytoglobin globin X nitrite reductase S -nitrosylation Daniela Giordano Cinzia Verde Paola Corti Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
topic_facet |
nitric oxide synthase Antarctic fish hemoglobin myoglobin neuroglobin cytoglobin globin X nitrite reductase S -nitrosylation |
description |
Nitric Oxide (NO) is a free radical with numerous critical signaling roles in vertebrate physiology. Similar to mammals, in the teleost system the generation of sufficient amounts of NO is critical for the physiological function of the cardiovascular system. At the same time, NO amounts are strictly controlled and kept within basal levels to protect cells from NO toxicity. Changes in oxygen tension highly influence NO bioavailability and can modulate the mechanisms involved in maintaining the NO balance. While NO production and signaling appears to have general similarities with mammalian systems, the wide range of environmental adaptations made by fish, particularly with regards to differing oxygen availabilities in aquatic habitats, creates a foundation for a variety of in vivo models characterized by different implications of NO production and signaling. In this review, we present the biology of NO in the teleost cardiovascular system and summarize the mechanisms of NO production and signaling with a special emphasis on the role of globin proteins in NO metabolism. |
format |
Text |
author |
Daniela Giordano Cinzia Verde Paola Corti |
author_facet |
Daniela Giordano Cinzia Verde Paola Corti |
author_sort |
Daniela Giordano |
title |
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
title_short |
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
title_full |
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
title_fullStr |
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
title_full_unstemmed |
Nitric Oxide Production and Regulation in the Teleost Cardiovascular System |
title_sort |
nitric oxide production and regulation in the teleost cardiovascular system |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/antiox11050957 |
op_coverage |
agris |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Antioxidants; Volume 11; Issue 5; Pages: 957 |
op_relation |
ROS, RNS and RSS https://dx.doi.org/10.3390/antiox11050957 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/antiox11050957 |
container_title |
Antioxidants |
container_volume |
11 |
container_issue |
5 |
container_start_page |
957 |
_version_ |
1774724839343390720 |