The Protecting Activity of RIPACUT®: A New Therapeutic Approach Preserving Epithelial Health Based on the Combination of Iceland Lichen Extract, Silver Salt, and Sodium Hyaluronate
Epithelial integrity and function must be maintained in a dynamic healthy equilibrium, keeping unaltered the oxidative and inflammatory conditions and the microbiome of the cutaneous layers. Beside the skin, other mucous membranes can be injured, such as the nasal and anal ones, because of the conta...
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ftmdpi:oai:mdpi.com:/2075-1729/13/5/1088/ 2023-08-20T04:07:21+02:00 The Protecting Activity of RIPACUT®: A New Therapeutic Approach Preserving Epithelial Health Based on the Combination of Iceland Lichen Extract, Silver Salt, and Sodium Hyaluronate Raffaella Belvedere Nunzia Novizio Daniela Eletto Amalia Porta Umberto Di Maio Antonello Petrella agris 2023-04-26 application/pdf https://doi.org/10.3390/life13051088 EN eng Multidisciplinary Digital Publishing Institute Pharmaceutical Science https://dx.doi.org/10.3390/life13051088 https://creativecommons.org/licenses/by/4.0/ Life; Volume 13; Issue 5; Pages: 1088 RIPACUT ® sodium hyaluronate silver nitrate Iceland lichen extract oxidation anti-inflammatory activity antimicrobial effects Text 2023 ftmdpi https://doi.org/10.3390/life13051088 2023-08-01T09:51:19Z Epithelial integrity and function must be maintained in a dynamic healthy equilibrium, keeping unaltered the oxidative and inflammatory conditions and the microbiome of the cutaneous layers. Beside the skin, other mucous membranes can be injured, such as the nasal and anal ones, because of the contact with the external environment. Here, we detected the effects of RIPACUT®, a combination of Iceland lichen extract, silver salt and sodium hyaluronate that individually act in diverse biological ways. The findings we obtained on keratinocytes, nasal and intestinal epithelial cells reveal that this combination showed a marked antioxidant activity, further assessed by the DPPH assay. Additionally, by analyzing the release of the IL-1β, TNF-α and IL-6 cytokines, we proved the anti-inflammatory effect of RIPACUT®. In both cases, the main preserving action was due to Iceland lichen. We also observed a notable antimicrobial activity mediated by the silver compound. These data suggest that RIPACUT® could signify the basis for an attractive pharmacological approach to maintaining healthy epithelial conditions. Interestingly, this may be extended to the nasal and anal areas where it protects against oxidative, inflammatory and infectious insults. Thus, these outcomes encourage the creation of sprays or creams for which sodium hyaluronate can guarantee a surface film-forming effect. Text Iceland MDPI Open Access Publishing Life 13 5 1088 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
RIPACUT ® sodium hyaluronate silver nitrate Iceland lichen extract oxidation anti-inflammatory activity antimicrobial effects |
spellingShingle |
RIPACUT ® sodium hyaluronate silver nitrate Iceland lichen extract oxidation anti-inflammatory activity antimicrobial effects Raffaella Belvedere Nunzia Novizio Daniela Eletto Amalia Porta Umberto Di Maio Antonello Petrella The Protecting Activity of RIPACUT®: A New Therapeutic Approach Preserving Epithelial Health Based on the Combination of Iceland Lichen Extract, Silver Salt, and Sodium Hyaluronate |
topic_facet |
RIPACUT ® sodium hyaluronate silver nitrate Iceland lichen extract oxidation anti-inflammatory activity antimicrobial effects |
description |
Epithelial integrity and function must be maintained in a dynamic healthy equilibrium, keeping unaltered the oxidative and inflammatory conditions and the microbiome of the cutaneous layers. Beside the skin, other mucous membranes can be injured, such as the nasal and anal ones, because of the contact with the external environment. Here, we detected the effects of RIPACUT®, a combination of Iceland lichen extract, silver salt and sodium hyaluronate that individually act in diverse biological ways. The findings we obtained on keratinocytes, nasal and intestinal epithelial cells reveal that this combination showed a marked antioxidant activity, further assessed by the DPPH assay. Additionally, by analyzing the release of the IL-1β, TNF-α and IL-6 cytokines, we proved the anti-inflammatory effect of RIPACUT®. In both cases, the main preserving action was due to Iceland lichen. We also observed a notable antimicrobial activity mediated by the silver compound. These data suggest that RIPACUT® could signify the basis for an attractive pharmacological approach to maintaining healthy epithelial conditions. Interestingly, this may be extended to the nasal and anal areas where it protects against oxidative, inflammatory and infectious insults. Thus, these outcomes encourage the creation of sprays or creams for which sodium hyaluronate can guarantee a surface film-forming effect. |
format |
Text |
author |
Raffaella Belvedere Nunzia Novizio Daniela Eletto Amalia Porta Umberto Di Maio Antonello Petrella |
author_facet |
Raffaella Belvedere Nunzia Novizio Daniela Eletto Amalia Porta Umberto Di Maio Antonello Petrella |
author_sort |
Raffaella Belvedere |
title |
The Protecting Activity of RIPACUT®: A New Therapeutic Approach Preserving Epithelial Health Based on the Combination of Iceland Lichen Extract, Silver Salt, and Sodium Hyaluronate |
title_short |
The Protecting Activity of RIPACUT®: A New Therapeutic Approach Preserving Epithelial Health Based on the Combination of Iceland Lichen Extract, Silver Salt, and Sodium Hyaluronate |
title_full |
The Protecting Activity of RIPACUT®: A New Therapeutic Approach Preserving Epithelial Health Based on the Combination of Iceland Lichen Extract, Silver Salt, and Sodium Hyaluronate |
title_fullStr |
The Protecting Activity of RIPACUT®: A New Therapeutic Approach Preserving Epithelial Health Based on the Combination of Iceland Lichen Extract, Silver Salt, and Sodium Hyaluronate |
title_full_unstemmed |
The Protecting Activity of RIPACUT®: A New Therapeutic Approach Preserving Epithelial Health Based on the Combination of Iceland Lichen Extract, Silver Salt, and Sodium Hyaluronate |
title_sort |
protecting activity of ripacut®: a new therapeutic approach preserving epithelial health based on the combination of iceland lichen extract, silver salt, and sodium hyaluronate |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2023 |
url |
https://doi.org/10.3390/life13051088 |
op_coverage |
agris |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Life; Volume 13; Issue 5; Pages: 1088 |
op_relation |
Pharmaceutical Science https://dx.doi.org/10.3390/life13051088 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/life13051088 |
container_title |
Life |
container_volume |
13 |
container_issue |
5 |
container_start_page |
1088 |
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1774718935544889344 |