Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales
Lipid synthesis pathways of toothed whales have evolved since their movement from the terrestrial to marine environment. The synthesis and function of these endogenous lipids and affecting factors are still little understood. In this review, we focused on different omics approaches and techniques to...
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ftmdpi:oai:mdpi.com:/2075-1729/11/4/364/ 2023-08-20T04:10:09+02:00 Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales Jayan D. M. Senevirathna Shuichi Asakawa agris 2021-04-20 application/pdf https://doi.org/10.3390/life11040364 EN eng Multidisciplinary Digital Publishing Institute Radiobiology, Nuclear Medicine and Medical Imaging https://dx.doi.org/10.3390/life11040364 https://creativecommons.org/licenses/by/4.0/ Life; Volume 11; Issue 4; Pages: 364 genomics transcriptomics proteomics lipidomics radiation cetaceans Text 2021 ftmdpi https://doi.org/10.3390/life11040364 2023-08-01T01:32:24Z Lipid synthesis pathways of toothed whales have evolved since their movement from the terrestrial to marine environment. The synthesis and function of these endogenous lipids and affecting factors are still little understood. In this review, we focused on different omics approaches and techniques to investigate lipid metabolism and radiation impacts on lipids in toothed whales. The selected literature was screened, and capacities, possibilities, and future approaches for identifying unusual lipid synthesis pathways by omics were evaluated. Omics approaches were categorized into the four major disciplines: lipidomics, transcriptomics, genomics, and proteomics. Genomics and transcriptomics can together identify genes related to unique lipid synthesis. As lipids interact with proteins in the animal body, lipidomics, and proteomics can correlate by creating lipid-binding proteome maps to elucidate metabolism pathways. In lipidomics studies, recent mass spectroscopic methods can address lipid profiles; however, the determination of structures of lipids are challenging. As an environmental stress, the acoustic radiation has a significant effect on the alteration of lipid profiles. Radiation studies in different omics approaches revealed the necessity of multi-omics applications. This review concluded that a combination of many of the omics areas may elucidate the metabolism of lipids and possible hazards on lipids in toothed whales by radiation. Text toothed whales MDPI Open Access Publishing Life 11 4 364 |
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English |
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genomics transcriptomics proteomics lipidomics radiation cetaceans |
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genomics transcriptomics proteomics lipidomics radiation cetaceans Jayan D. M. Senevirathna Shuichi Asakawa Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales |
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genomics transcriptomics proteomics lipidomics radiation cetaceans |
description |
Lipid synthesis pathways of toothed whales have evolved since their movement from the terrestrial to marine environment. The synthesis and function of these endogenous lipids and affecting factors are still little understood. In this review, we focused on different omics approaches and techniques to investigate lipid metabolism and radiation impacts on lipids in toothed whales. The selected literature was screened, and capacities, possibilities, and future approaches for identifying unusual lipid synthesis pathways by omics were evaluated. Omics approaches were categorized into the four major disciplines: lipidomics, transcriptomics, genomics, and proteomics. Genomics and transcriptomics can together identify genes related to unique lipid synthesis. As lipids interact with proteins in the animal body, lipidomics, and proteomics can correlate by creating lipid-binding proteome maps to elucidate metabolism pathways. In lipidomics studies, recent mass spectroscopic methods can address lipid profiles; however, the determination of structures of lipids are challenging. As an environmental stress, the acoustic radiation has a significant effect on the alteration of lipid profiles. Radiation studies in different omics approaches revealed the necessity of multi-omics applications. This review concluded that a combination of many of the omics areas may elucidate the metabolism of lipids and possible hazards on lipids in toothed whales by radiation. |
format |
Text |
author |
Jayan D. M. Senevirathna Shuichi Asakawa |
author_facet |
Jayan D. M. Senevirathna Shuichi Asakawa |
author_sort |
Jayan D. M. Senevirathna |
title |
Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales |
title_short |
Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales |
title_full |
Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales |
title_fullStr |
Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales |
title_full_unstemmed |
Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales |
title_sort |
multi-omics approaches and radiation on lipid metabolism in toothed whales |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/life11040364 |
op_coverage |
agris |
genre |
toothed whales |
genre_facet |
toothed whales |
op_source |
Life; Volume 11; Issue 4; Pages: 364 |
op_relation |
Radiobiology, Nuclear Medicine and Medical Imaging https://dx.doi.org/10.3390/life11040364 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/life11040364 |
container_title |
Life |
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11 |
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4 |
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364 |
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