Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus, German Shepherd Dog, and Different Sheepdogs of European Origin
This study focused on the genomic differences between the Czechoslovakian wolfdog (CWD) and its ancestors, the Grey wolf (GW) and German Shepherd dog. The Saarloos wolfdog and Belgian Shepherd dog were also included to study the level of GW genetics retained in the genome of domesticated breeds. The...
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ftmdpi:oai:mdpi.com:/2073-4425/12/6/832/ 2023-08-20T04:05:48+02:00 Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus, German Shepherd Dog, and Different Sheepdogs of European Origin Nina Moravčíková Radovan Kasarda Radoslav Židek Luboš Vostrý Hana Vostrá-Vydrová Jakub Vašek Daniela Čílová agris 2021-05-28 application/pdf https://doi.org/10.3390/genes12060832 EN eng Multidisciplinary Digital Publishing Institute Population and Evolutionary Genetics and Genomics https://dx.doi.org/10.3390/genes12060832 https://creativecommons.org/licenses/by/4.0/ Genes; Volume 12; Issue 6; Pages: 832 behaviour dogs genomic diversity morphological traits protein-coding genes selection events Text 2021 ftmdpi https://doi.org/10.3390/genes12060832 2023-08-01T01:49:49Z This study focused on the genomic differences between the Czechoslovakian wolfdog (CWD) and its ancestors, the Grey wolf (GW) and German Shepherd dog. The Saarloos wolfdog and Belgian Shepherd dog were also included to study the level of GW genetics retained in the genome of domesticated breeds. The dataset consisted of 131 animals and 143,593 single nucleotide polymorphisms (SNPs). The effects of demographic history on the overall genome structure were determined by screening the distribution of the homozygous segments. The genetic variance distributed within and between groups was quantified by genetic distances, the FST index, and discriminant analysis of principal components. Fine-scale population stratification due to specific morphological and behavioural traits was assessed by principal component and factorial analyses. In the CWD, a demographic history effect was manifested mainly in a high genome-wide proportion of short homozygous segments corresponding to a historical load of inbreeding derived from founders. The observed proportion of long homozygous segments indicated that the inbreeding events shaped the CWD genome relatively recently compared to other groups. Even if there was a significant increase in genetic similarity among wolf-like breeds, they were genetically separated from each other. Moreover, this study showed that the CWD genome carries private alleles that are not found in either wolves or other dog breeds analysed in this study. Text Canis lupus MDPI Open Access Publishing Genes 12 6 832 |
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MDPI Open Access Publishing |
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English |
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behaviour dogs genomic diversity morphological traits protein-coding genes selection events |
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behaviour dogs genomic diversity morphological traits protein-coding genes selection events Nina Moravčíková Radovan Kasarda Radoslav Židek Luboš Vostrý Hana Vostrá-Vydrová Jakub Vašek Daniela Čílová Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus, German Shepherd Dog, and Different Sheepdogs of European Origin |
topic_facet |
behaviour dogs genomic diversity morphological traits protein-coding genes selection events |
description |
This study focused on the genomic differences between the Czechoslovakian wolfdog (CWD) and its ancestors, the Grey wolf (GW) and German Shepherd dog. The Saarloos wolfdog and Belgian Shepherd dog were also included to study the level of GW genetics retained in the genome of domesticated breeds. The dataset consisted of 131 animals and 143,593 single nucleotide polymorphisms (SNPs). The effects of demographic history on the overall genome structure were determined by screening the distribution of the homozygous segments. The genetic variance distributed within and between groups was quantified by genetic distances, the FST index, and discriminant analysis of principal components. Fine-scale population stratification due to specific morphological and behavioural traits was assessed by principal component and factorial analyses. In the CWD, a demographic history effect was manifested mainly in a high genome-wide proportion of short homozygous segments corresponding to a historical load of inbreeding derived from founders. The observed proportion of long homozygous segments indicated that the inbreeding events shaped the CWD genome relatively recently compared to other groups. Even if there was a significant increase in genetic similarity among wolf-like breeds, they were genetically separated from each other. Moreover, this study showed that the CWD genome carries private alleles that are not found in either wolves or other dog breeds analysed in this study. |
format |
Text |
author |
Nina Moravčíková Radovan Kasarda Radoslav Židek Luboš Vostrý Hana Vostrá-Vydrová Jakub Vašek Daniela Čílová |
author_facet |
Nina Moravčíková Radovan Kasarda Radoslav Židek Luboš Vostrý Hana Vostrá-Vydrová Jakub Vašek Daniela Čílová |
author_sort |
Nina Moravčíková |
title |
Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus, German Shepherd Dog, and Different Sheepdogs of European Origin |
title_short |
Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus, German Shepherd Dog, and Different Sheepdogs of European Origin |
title_full |
Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus, German Shepherd Dog, and Different Sheepdogs of European Origin |
title_fullStr |
Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus, German Shepherd Dog, and Different Sheepdogs of European Origin |
title_full_unstemmed |
Czechoslovakian Wolfdog Genomic Divergence from Its Ancestors Canis lupus, German Shepherd Dog, and Different Sheepdogs of European Origin |
title_sort |
czechoslovakian wolfdog genomic divergence from its ancestors canis lupus, german shepherd dog, and different sheepdogs of european origin |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/genes12060832 |
op_coverage |
agris |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Genes; Volume 12; Issue 6; Pages: 832 |
op_relation |
Population and Evolutionary Genetics and Genomics https://dx.doi.org/10.3390/genes12060832 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/genes12060832 |
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Genes |
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12 |
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6 |
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832 |
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1774716546478768128 |