Genome-Wide Association Study Confirms Previous Findings of Major Loci Affecting Resistance to Piscine myocarditis virus in Atlantic Salmon (Salmo salar L.)
Cardiomyopathy syndrome is a viral disease of Atlantic salmon, mostly affecting fish during the late stages of production, resulting in significant losses to the industry. It has been shown that resistance to this disease has a strong genetic component, with quantitative trait loci (QTL) on chromoso...
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ftmdpi:oai:mdpi.com:/2073-4425/11/6/608/ 2023-08-20T04:05:15+02:00 Genome-Wide Association Study Confirms Previous Findings of Major Loci Affecting Resistance to Piscine myocarditis virus in Atlantic Salmon (Salmo salar L.) Borghild Hillestad Ólafur H. Kristjánsson Shokouh Makvandi-Nejad Hooman K. Moghadam agris 2020-05-30 application/pdf https://doi.org/10.3390/genes11060608 EN eng Multidisciplinary Digital Publishing Institute Animal Genetics and Genomics https://dx.doi.org/10.3390/genes11060608 https://creativecommons.org/licenses/by/4.0/ Genes; Volume 11; Issue 6; Pages: 608 Atlantic salmon cardiomyopathy syndrome (CMS) Piscine myocarditis virus (PMCV) genome-wide association study (GWAS) single-nucleotide polymorphism (SNP) heritability breeding Text 2020 ftmdpi https://doi.org/10.3390/genes11060608 2023-07-31T23:34:26Z Cardiomyopathy syndrome is a viral disease of Atlantic salmon, mostly affecting fish during the late stages of production, resulting in significant losses to the industry. It has been shown that resistance to this disease has a strong genetic component, with quantitative trait loci (QTL) on chromosomes 27 (Ssa27) and Ssa12 to explain most of the additive genetic variance. Here, by analysing animals from a different year-class and a different population, we further aimed to confirm and narrow down the locations of these QTL. The data support the existence of the two QTL and suggest that the causative mutation on Ssa27 is most likely within the 10–10.5 Mbp segment of this chromosome. This region contains a cluster of major histocompatibility complex class I (MHC I) genes with the most strongly associated marker mapped to one of these loci. On Ssa12, the data confirmed the previous finding that the location of the causative mutation is within the 61.3 to 61.7 Mbp region. This segment contains several immune-related genes, but of particular interest are genes related to MHC II. Together, these findings highlight the likely key role of MHC genes in Atlantic salmon following infection with Piscine myocarditis virus (PMCV) and their potential impact on influencing the trajectory of this disease. Text Atlantic salmon Salmo salar MDPI Open Access Publishing Genes 11 6 608 |
institution |
Open Polar |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
Atlantic salmon cardiomyopathy syndrome (CMS) Piscine myocarditis virus (PMCV) genome-wide association study (GWAS) single-nucleotide polymorphism (SNP) heritability breeding |
spellingShingle |
Atlantic salmon cardiomyopathy syndrome (CMS) Piscine myocarditis virus (PMCV) genome-wide association study (GWAS) single-nucleotide polymorphism (SNP) heritability breeding Borghild Hillestad Ólafur H. Kristjánsson Shokouh Makvandi-Nejad Hooman K. Moghadam Genome-Wide Association Study Confirms Previous Findings of Major Loci Affecting Resistance to Piscine myocarditis virus in Atlantic Salmon (Salmo salar L.) |
topic_facet |
Atlantic salmon cardiomyopathy syndrome (CMS) Piscine myocarditis virus (PMCV) genome-wide association study (GWAS) single-nucleotide polymorphism (SNP) heritability breeding |
description |
Cardiomyopathy syndrome is a viral disease of Atlantic salmon, mostly affecting fish during the late stages of production, resulting in significant losses to the industry. It has been shown that resistance to this disease has a strong genetic component, with quantitative trait loci (QTL) on chromosomes 27 (Ssa27) and Ssa12 to explain most of the additive genetic variance. Here, by analysing animals from a different year-class and a different population, we further aimed to confirm and narrow down the locations of these QTL. The data support the existence of the two QTL and suggest that the causative mutation on Ssa27 is most likely within the 10–10.5 Mbp segment of this chromosome. This region contains a cluster of major histocompatibility complex class I (MHC I) genes with the most strongly associated marker mapped to one of these loci. On Ssa12, the data confirmed the previous finding that the location of the causative mutation is within the 61.3 to 61.7 Mbp region. This segment contains several immune-related genes, but of particular interest are genes related to MHC II. Together, these findings highlight the likely key role of MHC genes in Atlantic salmon following infection with Piscine myocarditis virus (PMCV) and their potential impact on influencing the trajectory of this disease. |
format |
Text |
author |
Borghild Hillestad Ólafur H. Kristjánsson Shokouh Makvandi-Nejad Hooman K. Moghadam |
author_facet |
Borghild Hillestad Ólafur H. Kristjánsson Shokouh Makvandi-Nejad Hooman K. Moghadam |
author_sort |
Borghild Hillestad |
title |
Genome-Wide Association Study Confirms Previous Findings of Major Loci Affecting Resistance to Piscine myocarditis virus in Atlantic Salmon (Salmo salar L.) |
title_short |
Genome-Wide Association Study Confirms Previous Findings of Major Loci Affecting Resistance to Piscine myocarditis virus in Atlantic Salmon (Salmo salar L.) |
title_full |
Genome-Wide Association Study Confirms Previous Findings of Major Loci Affecting Resistance to Piscine myocarditis virus in Atlantic Salmon (Salmo salar L.) |
title_fullStr |
Genome-Wide Association Study Confirms Previous Findings of Major Loci Affecting Resistance to Piscine myocarditis virus in Atlantic Salmon (Salmo salar L.) |
title_full_unstemmed |
Genome-Wide Association Study Confirms Previous Findings of Major Loci Affecting Resistance to Piscine myocarditis virus in Atlantic Salmon (Salmo salar L.) |
title_sort |
genome-wide association study confirms previous findings of major loci affecting resistance to piscine myocarditis virus in atlantic salmon (salmo salar l.) |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2020 |
url |
https://doi.org/10.3390/genes11060608 |
op_coverage |
agris |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Genes; Volume 11; Issue 6; Pages: 608 |
op_relation |
Animal Genetics and Genomics https://dx.doi.org/10.3390/genes11060608 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/genes11060608 |
container_title |
Genes |
container_volume |
11 |
container_issue |
6 |
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608 |
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1774715738356973568 |