Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications
Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. Herein, we have synthesized amphiphilic copolymers by grafting hydrophobic alkyl/perf...
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ftmdpi:oai:mdpi.com:/2073-4360/8/8/311/ 2023-08-20T04:02:34+02:00 Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications Badri Parshad Meena Kumari Katharina Achazi Christoph Bӧttcher Rainer Haag Sunil Sharma 2016-08-18 application/pdf https://doi.org/10.3390/polym8080311 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/polym8080311 https://creativecommons.org/licenses/by/4.0/ Polymers; Volume 8; Issue 8; Pages: 311 fluorinated amphiphilic polymers self-assembly nanocarriers drug encapsulation enzymatic release Text 2016 ftmdpi https://doi.org/10.3390/polym8080311 2023-07-31T20:56:13Z Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. Herein, we have synthesized amphiphilic copolymers by grafting hydrophobic alkyl/perfluoroalkyl chains and hydrophilic polyglycerol [G2.0] dendrons onto a co-polymer scaffold, which itself was prepared by enzymatic polymerization of poly[ethylene glycol bis(carboxymethyl) ether]diethylester and 2-azidopropan-1,3-diol. The resulting fluorinated polymers and their alkyl chain analogs were then compared in terms of their supramolecular aggregation behavior, solubilization capacity, transport potential, and release profile using curcumin and dexamethasone drugs. The study of the release profile of encapsulated curcumin incubated with/without a hydrolase enzyme Candida antarctica lipase (CAL-B) suggested that the drug is better stabilized in perfluoroalkyl chain grafted polymeric nanostructures in the absence of enzyme for up to 12 days as compared to its alkyl chain analogs. Although both the fluorinated as well as non-fluorinated systems showed up to 90% release of curcumin in 12 days when incubated with lipase, a comparatively faster release was observed in the fluorinated polymers. Cell viability of HeLa cells up to 95% in aqueous solution of fluorinated polymers (100 μg/mL) demonstrated their excellent cyto-compatibility. Text Antarc* Antarctica MDPI Open Access Publishing Polymers 8 8 311 |
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MDPI Open Access Publishing |
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ftmdpi |
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English |
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fluorinated amphiphilic polymers self-assembly nanocarriers drug encapsulation enzymatic release |
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fluorinated amphiphilic polymers self-assembly nanocarriers drug encapsulation enzymatic release Badri Parshad Meena Kumari Katharina Achazi Christoph Bӧttcher Rainer Haag Sunil Sharma Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications |
topic_facet |
fluorinated amphiphilic polymers self-assembly nanocarriers drug encapsulation enzymatic release |
description |
Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. Herein, we have synthesized amphiphilic copolymers by grafting hydrophobic alkyl/perfluoroalkyl chains and hydrophilic polyglycerol [G2.0] dendrons onto a co-polymer scaffold, which itself was prepared by enzymatic polymerization of poly[ethylene glycol bis(carboxymethyl) ether]diethylester and 2-azidopropan-1,3-diol. The resulting fluorinated polymers and their alkyl chain analogs were then compared in terms of their supramolecular aggregation behavior, solubilization capacity, transport potential, and release profile using curcumin and dexamethasone drugs. The study of the release profile of encapsulated curcumin incubated with/without a hydrolase enzyme Candida antarctica lipase (CAL-B) suggested that the drug is better stabilized in perfluoroalkyl chain grafted polymeric nanostructures in the absence of enzyme for up to 12 days as compared to its alkyl chain analogs. Although both the fluorinated as well as non-fluorinated systems showed up to 90% release of curcumin in 12 days when incubated with lipase, a comparatively faster release was observed in the fluorinated polymers. Cell viability of HeLa cells up to 95% in aqueous solution of fluorinated polymers (100 μg/mL) demonstrated their excellent cyto-compatibility. |
format |
Text |
author |
Badri Parshad Meena Kumari Katharina Achazi Christoph Bӧttcher Rainer Haag Sunil Sharma |
author_facet |
Badri Parshad Meena Kumari Katharina Achazi Christoph Bӧttcher Rainer Haag Sunil Sharma |
author_sort |
Badri Parshad |
title |
Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications |
title_short |
Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications |
title_full |
Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications |
title_fullStr |
Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications |
title_full_unstemmed |
Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications |
title_sort |
chemo-enzymatic synthesis of perfluoroalkyl-functionalized dendronized polymers as cyto-compatible nanocarriers for drug delivery applications |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2016 |
url |
https://doi.org/10.3390/polym8080311 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Polymers; Volume 8; Issue 8; Pages: 311 |
op_relation |
https://dx.doi.org/10.3390/polym8080311 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/polym8080311 |
container_title |
Polymers |
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8 |
container_issue |
8 |
container_start_page |
311 |
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1774713081995198464 |