Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications

Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. Herein, we have synthesized amphiphilic copolymers by grafting hydrophobic alkyl/perf...

Full description

Bibliographic Details
Published in:Polymers
Main Authors: Badri Parshad, Meena Kumari, Katharina Achazi, Christoph Bӧttcher, Rainer Haag, Sunil Sharma
Format: Text
Language:English
Published: Multidisciplinary Digital Publishing Institute 2016
Subjects:
Online Access:https://doi.org/10.3390/polym8080311
id ftmdpi:oai:mdpi.com:/2073-4360/8/8/311/
record_format openpolar
spelling ftmdpi:oai:mdpi.com:/2073-4360/8/8/311/ 2023-08-20T04:02:34+02:00 Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications Badri Parshad Meena Kumari Katharina Achazi Christoph Bӧttcher Rainer Haag Sunil Sharma 2016-08-18 application/pdf https://doi.org/10.3390/polym8080311 EN eng Multidisciplinary Digital Publishing Institute https://dx.doi.org/10.3390/polym8080311 https://creativecommons.org/licenses/by/4.0/ Polymers; Volume 8; Issue 8; Pages: 311 fluorinated amphiphilic polymers self-assembly nanocarriers drug encapsulation enzymatic release Text 2016 ftmdpi https://doi.org/10.3390/polym8080311 2023-07-31T20:56:13Z Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. Herein, we have synthesized amphiphilic copolymers by grafting hydrophobic alkyl/perfluoroalkyl chains and hydrophilic polyglycerol [G2.0] dendrons onto a co-polymer scaffold, which itself was prepared by enzymatic polymerization of poly[ethylene glycol bis(carboxymethyl) ether]diethylester and 2-azidopropan-1,3-diol. The resulting fluorinated polymers and their alkyl chain analogs were then compared in terms of their supramolecular aggregation behavior, solubilization capacity, transport potential, and release profile using curcumin and dexamethasone drugs. The study of the release profile of encapsulated curcumin incubated with/without a hydrolase enzyme Candida antarctica lipase (CAL-B) suggested that the drug is better stabilized in perfluoroalkyl chain grafted polymeric nanostructures in the absence of enzyme for up to 12 days as compared to its alkyl chain analogs. Although both the fluorinated as well as non-fluorinated systems showed up to 90% release of curcumin in 12 days when incubated with lipase, a comparatively faster release was observed in the fluorinated polymers. Cell viability of HeLa cells up to 95% in aqueous solution of fluorinated polymers (100 μg/mL) demonstrated their excellent cyto-compatibility. Text Antarc* Antarctica MDPI Open Access Publishing Polymers 8 8 311
institution Open Polar
collection MDPI Open Access Publishing
op_collection_id ftmdpi
language English
topic fluorinated amphiphilic polymers
self-assembly
nanocarriers
drug encapsulation
enzymatic release
spellingShingle fluorinated amphiphilic polymers
self-assembly
nanocarriers
drug encapsulation
enzymatic release
Badri Parshad
Meena Kumari
Katharina Achazi
Christoph Bӧttcher
Rainer Haag
Sunil Sharma
Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications
topic_facet fluorinated amphiphilic polymers
self-assembly
nanocarriers
drug encapsulation
enzymatic release
description Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. Herein, we have synthesized amphiphilic copolymers by grafting hydrophobic alkyl/perfluoroalkyl chains and hydrophilic polyglycerol [G2.0] dendrons onto a co-polymer scaffold, which itself was prepared by enzymatic polymerization of poly[ethylene glycol bis(carboxymethyl) ether]diethylester and 2-azidopropan-1,3-diol. The resulting fluorinated polymers and their alkyl chain analogs were then compared in terms of their supramolecular aggregation behavior, solubilization capacity, transport potential, and release profile using curcumin and dexamethasone drugs. The study of the release profile of encapsulated curcumin incubated with/without a hydrolase enzyme Candida antarctica lipase (CAL-B) suggested that the drug is better stabilized in perfluoroalkyl chain grafted polymeric nanostructures in the absence of enzyme for up to 12 days as compared to its alkyl chain analogs. Although both the fluorinated as well as non-fluorinated systems showed up to 90% release of curcumin in 12 days when incubated with lipase, a comparatively faster release was observed in the fluorinated polymers. Cell viability of HeLa cells up to 95% in aqueous solution of fluorinated polymers (100 μg/mL) demonstrated their excellent cyto-compatibility.
format Text
author Badri Parshad
Meena Kumari
Katharina Achazi
Christoph Bӧttcher
Rainer Haag
Sunil Sharma
author_facet Badri Parshad
Meena Kumari
Katharina Achazi
Christoph Bӧttcher
Rainer Haag
Sunil Sharma
author_sort Badri Parshad
title Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications
title_short Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications
title_full Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications
title_fullStr Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications
title_full_unstemmed Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications
title_sort chemo-enzymatic synthesis of perfluoroalkyl-functionalized dendronized polymers as cyto-compatible nanocarriers for drug delivery applications
publisher Multidisciplinary Digital Publishing Institute
publishDate 2016
url https://doi.org/10.3390/polym8080311
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_source Polymers; Volume 8; Issue 8; Pages: 311
op_relation https://dx.doi.org/10.3390/polym8080311
op_rights https://creativecommons.org/licenses/by/4.0/
op_doi https://doi.org/10.3390/polym8080311
container_title Polymers
container_volume 8
container_issue 8
container_start_page 311
_version_ 1774713081995198464