Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention
Community-driven projects have characterized Helicobacter pylori (Hp) infection in Indigenous communities in the Northwest Territories (NT) and Yukon (YT), Canada. These projects address concerns about the frequent diagnosis of Hp infection among community members and its relation to gastric cancer...
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ftmdpi:oai:mdpi.com:/2072-6694/15/15/3950/ 2023-10-01T03:53:52+02:00 Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention Ting Wang Safwat Girgis Hsiu-Ju Chang Ali Assi Katharine Fagan-Garcia Taylor Cromarty Rachel Munday Karen J. Goodman Sander Veldhuyzen van Zanten the CANHelp Working Group the CANHelp Working Group 2023-08-03 application/pdf https://doi.org/10.3390/cancers15153950 eng eng Multidisciplinary Digital Publishing Institute Tumor Microenvironment https://dx.doi.org/10.3390/cancers15153950 https://creativecommons.org/licenses/by/4.0/ Cancers Volume 15 Issue 15 Pages: 3950 Helicobacter pylori Arctic Canada indigenous health gastritis active gastritis chronic gastritis atrophic gastritis intestinal metaplasia gastric cancer Text 2023 ftmdpi https://doi.org/10.3390/cancers15153950 2023-09-03T23:53:42Z Community-driven projects have characterized Helicobacter pylori (Hp) infection in Indigenous communities in the Northwest Territories (NT) and Yukon (YT), Canada. These projects address concerns about the frequent diagnosis of Hp infection among community members and its relation to gastric cancer deaths, perceived to occur with alarming frequency in this region. Projects included breath-test screening for Hp infection, gastroscopy with gastric biopsies, and treatment to eliminate Hp infection. Previous project results showed a high prevalence of stomach pathologies associated with increased cancer risk among Hp-positive participants at baseline. This analysis describes changes in precancerous gastric pathologies in project participants who had gastroscopy before baseline treatment during 2008–2013 and again in 2017. Throughout the study period, the same pathologist graded Hp density, active gastritis, chronic gastritis, atrophic gastritis, and intestinal metaplasia using the updated Sydney System. Of 310 participants from three communities with baseline pathology data, 69 had follow-up pathology data. Relative to baseline, the prevalence of Hp infection and precancerous gastric pathology was substantially lower at follow-up; most participants who were Hp-positive at baseline and Hp-negative at follow-up had reduced severity of active, chronic, and/or atrophic gastritis at follow-up. Though follow-up numbers are small, these results yield evidence that successful Hp treatment has the potential to reduce the risk of gastric cancer in Arctic Indigenous communities. Text Arctic Northwest Territories Yukon MDPI Open Access Publishing Arctic Yukon Northwest Territories Canada Cancers 15 15 3950 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
Helicobacter pylori Arctic Canada indigenous health gastritis active gastritis chronic gastritis atrophic gastritis intestinal metaplasia gastric cancer |
spellingShingle |
Helicobacter pylori Arctic Canada indigenous health gastritis active gastritis chronic gastritis atrophic gastritis intestinal metaplasia gastric cancer Ting Wang Safwat Girgis Hsiu-Ju Chang Ali Assi Katharine Fagan-Garcia Taylor Cromarty Rachel Munday Karen J. Goodman Sander Veldhuyzen van Zanten the CANHelp Working Group the CANHelp Working Group Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
topic_facet |
Helicobacter pylori Arctic Canada indigenous health gastritis active gastritis chronic gastritis atrophic gastritis intestinal metaplasia gastric cancer |
description |
Community-driven projects have characterized Helicobacter pylori (Hp) infection in Indigenous communities in the Northwest Territories (NT) and Yukon (YT), Canada. These projects address concerns about the frequent diagnosis of Hp infection among community members and its relation to gastric cancer deaths, perceived to occur with alarming frequency in this region. Projects included breath-test screening for Hp infection, gastroscopy with gastric biopsies, and treatment to eliminate Hp infection. Previous project results showed a high prevalence of stomach pathologies associated with increased cancer risk among Hp-positive participants at baseline. This analysis describes changes in precancerous gastric pathologies in project participants who had gastroscopy before baseline treatment during 2008–2013 and again in 2017. Throughout the study period, the same pathologist graded Hp density, active gastritis, chronic gastritis, atrophic gastritis, and intestinal metaplasia using the updated Sydney System. Of 310 participants from three communities with baseline pathology data, 69 had follow-up pathology data. Relative to baseline, the prevalence of Hp infection and precancerous gastric pathology was substantially lower at follow-up; most participants who were Hp-positive at baseline and Hp-negative at follow-up had reduced severity of active, chronic, and/or atrophic gastritis at follow-up. Though follow-up numbers are small, these results yield evidence that successful Hp treatment has the potential to reduce the risk of gastric cancer in Arctic Indigenous communities. |
format |
Text |
author |
Ting Wang Safwat Girgis Hsiu-Ju Chang Ali Assi Katharine Fagan-Garcia Taylor Cromarty Rachel Munday Karen J. Goodman Sander Veldhuyzen van Zanten the CANHelp Working Group the CANHelp Working Group |
author_facet |
Ting Wang Safwat Girgis Hsiu-Ju Chang Ali Assi Katharine Fagan-Garcia Taylor Cromarty Rachel Munday Karen J. Goodman Sander Veldhuyzen van Zanten the CANHelp Working Group the CANHelp Working Group |
author_sort |
Ting Wang |
title |
Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
title_short |
Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
title_full |
Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
title_fullStr |
Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
title_full_unstemmed |
Changes in Gastric Pathology after H. pylori Treatment in Community-Driven Research Aimed at Gastric Cancer Prevention |
title_sort |
changes in gastric pathology after h. pylori treatment in community-driven research aimed at gastric cancer prevention |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2023 |
url |
https://doi.org/10.3390/cancers15153950 |
geographic |
Arctic Yukon Northwest Territories Canada |
geographic_facet |
Arctic Yukon Northwest Territories Canada |
genre |
Arctic Northwest Territories Yukon |
genre_facet |
Arctic Northwest Territories Yukon |
op_source |
Cancers Volume 15 Issue 15 Pages: 3950 |
op_relation |
Tumor Microenvironment https://dx.doi.org/10.3390/cancers15153950 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/cancers15153950 |
container_title |
Cancers |
container_volume |
15 |
container_issue |
15 |
container_start_page |
3950 |
_version_ |
1778520906600022016 |