Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice
Dietary fish intake has proven to have health benefits in humans. n-3 polyunsaturated fatty acids (PUFAs) in fish oil (FO), especially, may provide protection against age-related cognitive disorders. Owing to the unique benefits of n-3 PUFAs, other nutrients, such as fish protein (FP), have not been...
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ftmdpi:oai:mdpi.com:/2072-6643/14/21/4618/ 2023-08-20T03:59:15+02:00 Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice Yuki Murakami Ryota Hosomi Ayano Nishimoto Toshimasa Nishiyama Munehiro Yoshida Kenji Fukunaga agris 2022-11-02 application/pdf https://doi.org/10.3390/nu14214618 EN eng Multidisciplinary Digital Publishing Institute Nutrition and Public Health https://dx.doi.org/10.3390/nu14214618 https://creativecommons.org/licenses/by/4.0/ Nutrients; Volume 14; Issue 21; Pages: 4618 fish protein fish oil senescence-accelerated mouse prone 10 cognitive decline demyelination Text 2022 ftmdpi https://doi.org/10.3390/nu14214618 2023-08-01T07:09:31Z Dietary fish intake has proven to have health benefits in humans. n-3 polyunsaturated fatty acids (PUFAs) in fish oil (FO), especially, may provide protection against age-related cognitive disorders. Owing to the unique benefits of n-3 PUFAs, other nutrients, such as fish protein (FP), have not been well studied. To clarify the effects of FO and FP on brain function, we investigated whether FO or FP feeding can prevent age-related cognitive dysfunction in senescence-accelerated mouse-prone 10 (SAMP10) mice. The FP group maintained a better working memory compared to the control and FO groups in the Y-maze test, but not episodic memory in the novel object recognition test. To evaluate demyelination levels, we measured neurofilament H (NfH) and myelin basic protein (MBP) immunoreactivity in the hippocampus (Hipp). Axon morphology was maintained in the FP group, but not in the control and FO groups. Additionally, the percentage of positive area for double-staining with NfH/MPB was significantly higher in the Hipp of FP-fed mice than in the control (p < 0.05). These results suggest that FP intake prevents age-related cognitive dysfunction by maintaining axonal morphology in the Hipp of SAMP10 mice. Text alaska pollock Alaska MDPI Open Access Publishing The ''Y'' ENVELOPE(-112.453,-112.453,57.591,57.591) Nutrients 14 21 4618 |
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MDPI Open Access Publishing |
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fish protein fish oil senescence-accelerated mouse prone 10 cognitive decline demyelination |
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fish protein fish oil senescence-accelerated mouse prone 10 cognitive decline demyelination Yuki Murakami Ryota Hosomi Ayano Nishimoto Toshimasa Nishiyama Munehiro Yoshida Kenji Fukunaga Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
topic_facet |
fish protein fish oil senescence-accelerated mouse prone 10 cognitive decline demyelination |
description |
Dietary fish intake has proven to have health benefits in humans. n-3 polyunsaturated fatty acids (PUFAs) in fish oil (FO), especially, may provide protection against age-related cognitive disorders. Owing to the unique benefits of n-3 PUFAs, other nutrients, such as fish protein (FP), have not been well studied. To clarify the effects of FO and FP on brain function, we investigated whether FO or FP feeding can prevent age-related cognitive dysfunction in senescence-accelerated mouse-prone 10 (SAMP10) mice. The FP group maintained a better working memory compared to the control and FO groups in the Y-maze test, but not episodic memory in the novel object recognition test. To evaluate demyelination levels, we measured neurofilament H (NfH) and myelin basic protein (MBP) immunoreactivity in the hippocampus (Hipp). Axon morphology was maintained in the FP group, but not in the control and FO groups. Additionally, the percentage of positive area for double-staining with NfH/MPB was significantly higher in the Hipp of FP-fed mice than in the control (p < 0.05). These results suggest that FP intake prevents age-related cognitive dysfunction by maintaining axonal morphology in the Hipp of SAMP10 mice. |
format |
Text |
author |
Yuki Murakami Ryota Hosomi Ayano Nishimoto Toshimasa Nishiyama Munehiro Yoshida Kenji Fukunaga |
author_facet |
Yuki Murakami Ryota Hosomi Ayano Nishimoto Toshimasa Nishiyama Munehiro Yoshida Kenji Fukunaga |
author_sort |
Yuki Murakami |
title |
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
title_short |
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
title_full |
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
title_fullStr |
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
title_full_unstemmed |
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice |
title_sort |
protective effects of fish (alaska pollock) protein intake against short-term memory decline in senescence-accelerated mice |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/nu14214618 |
op_coverage |
agris |
long_lat |
ENVELOPE(-112.453,-112.453,57.591,57.591) |
geographic |
The ''Y'' |
geographic_facet |
The ''Y'' |
genre |
alaska pollock Alaska |
genre_facet |
alaska pollock Alaska |
op_source |
Nutrients; Volume 14; Issue 21; Pages: 4618 |
op_relation |
Nutrition and Public Health https://dx.doi.org/10.3390/nu14214618 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/nu14214618 |
container_title |
Nutrients |
container_volume |
14 |
container_issue |
21 |
container_start_page |
4618 |
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1774724723384516608 |