Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis
The aim of this study was to examine the effects of Antarctic krill oil (FJH-KO) in a rat model of monosodium iodoacetate (MIA) induced osteoarthritis. The effect of FJH-KO on the development and severity of MIA-induced osteoarthritis was assessed using hematoxylin and eosin (H&E) staining and m...
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ftmdpi:oai:mdpi.com:/2072-6643/12/11/3550/ 2023-08-20T04:00:14+02:00 Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis Minhee Lee Dakyung Kim Soo-Jeung Park Jeong moon Yun Dong Hwan Oh Jeongmin Lee agris 2020-11-20 application/pdf https://doi.org/10.3390/nu12113550 EN eng Multidisciplinary Digital Publishing Institute Phytochemicals and Human Health https://dx.doi.org/10.3390/nu12113550 https://creativecommons.org/licenses/by/4.0/ Nutrients; Volume 12; Issue 11; Pages: 3550 Antarctic krill oil monoiodoacetate osteoarthritis Text 2020 ftmdpi https://doi.org/10.3390/nu12113550 2023-08-01T00:29:52Z The aim of this study was to examine the effects of Antarctic krill oil (FJH-KO) in a rat model of monosodium iodoacetate (MIA) induced osteoarthritis. The effect of FJH-KO on the development and severity of MIA-induced osteoarthritis was assessed using hematoxylin and eosin (H&E) staining and micro-CT. The expression of PGE2, pro-inflammatory cytokines (IL-1β, TNF-α), and arthritics related genes in osteoarthritic rats in response to FJH-KO supplementation was investigated using real time PCR. FJH-KO supplementation in the arthritic rat model reduced tissue damage, cartilage degeneration, and reduced the MIA-induced irregularities in articular cartilage surface. Serum PGE2, IL-1β, IL-6, and TNF-α levels were higher in MIA treated animals, but these levels decreased upon FJH-KO supplementation. When FJH-KO was provided at a dose of 150 mg/kg b.w to MIA-treated animals, it significantly increased the mRNA expression of anabolic factors. The mRNA expression of catabolic factors was significantly decreased MIA-treated animals that were provided FJH-KO at a dose of 100 and 150 mg/kg b.w. Moreover, the mRNA expression of inflammatory mediators was significantly decreased MIA-treated animals supplemented with FJH-KO. These results suggest supplementation with FJH-KO ameliorates the irregularities in articular cartilage surface and improves the inflammatory response in the osteoarthritis. Thus, FJH-KO could serve as a potential therapeutic agent for osteoarthritis treatment. Text Antarc* Antarctic Antarctic Krill MDPI Open Access Publishing Antarctic Nutrients 12 11 3550 |
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English |
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Antarctic krill oil monoiodoacetate osteoarthritis |
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Antarctic krill oil monoiodoacetate osteoarthritis Minhee Lee Dakyung Kim Soo-Jeung Park Jeong moon Yun Dong Hwan Oh Jeongmin Lee Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
topic_facet |
Antarctic krill oil monoiodoacetate osteoarthritis |
description |
The aim of this study was to examine the effects of Antarctic krill oil (FJH-KO) in a rat model of monosodium iodoacetate (MIA) induced osteoarthritis. The effect of FJH-KO on the development and severity of MIA-induced osteoarthritis was assessed using hematoxylin and eosin (H&E) staining and micro-CT. The expression of PGE2, pro-inflammatory cytokines (IL-1β, TNF-α), and arthritics related genes in osteoarthritic rats in response to FJH-KO supplementation was investigated using real time PCR. FJH-KO supplementation in the arthritic rat model reduced tissue damage, cartilage degeneration, and reduced the MIA-induced irregularities in articular cartilage surface. Serum PGE2, IL-1β, IL-6, and TNF-α levels were higher in MIA treated animals, but these levels decreased upon FJH-KO supplementation. When FJH-KO was provided at a dose of 150 mg/kg b.w to MIA-treated animals, it significantly increased the mRNA expression of anabolic factors. The mRNA expression of catabolic factors was significantly decreased MIA-treated animals that were provided FJH-KO at a dose of 100 and 150 mg/kg b.w. Moreover, the mRNA expression of inflammatory mediators was significantly decreased MIA-treated animals supplemented with FJH-KO. These results suggest supplementation with FJH-KO ameliorates the irregularities in articular cartilage surface and improves the inflammatory response in the osteoarthritis. Thus, FJH-KO could serve as a potential therapeutic agent for osteoarthritis treatment. |
format |
Text |
author |
Minhee Lee Dakyung Kim Soo-Jeung Park Jeong moon Yun Dong Hwan Oh Jeongmin Lee |
author_facet |
Minhee Lee Dakyung Kim Soo-Jeung Park Jeong moon Yun Dong Hwan Oh Jeongmin Lee |
author_sort |
Minhee Lee |
title |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
title_short |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
title_full |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
title_fullStr |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
title_full_unstemmed |
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis |
title_sort |
antarctic krill oil ameliorates monosodium iodoacetate-induced irregularities in articular cartilage and inflammatory response in the rat models of osteoarthritis |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2020 |
url |
https://doi.org/10.3390/nu12113550 |
op_coverage |
agris |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_source |
Nutrients; Volume 12; Issue 11; Pages: 3550 |
op_relation |
Phytochemicals and Human Health https://dx.doi.org/10.3390/nu12113550 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/nu12113550 |
container_title |
Nutrients |
container_volume |
12 |
container_issue |
11 |
container_start_page |
3550 |
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1774717180231811072 |