Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives
A total of 381 hepatitis B virus (HBV) DNA sequences collected from nine groups of Siberian native populations were phylogenetically analyzed along with 179 HBV strains sampled in different urban populations of former western USSR republics and 50 strains from Central Asian republics and Mongolia. D...
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ftmdpi:oai:mdpi.com:/1999-4915/14/11/2465/ 2023-08-20T04:05:56+02:00 Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives Victor Manuylov Vladimir Chulanov Ludmila Bezuglova Elena Chub Anastasia Karlsen Karen Kyuregyan Yulia Ostankova Alexander Semenov Ludmila Osipova Tatjana Tallo Irina Netesova Artem Tkachuk Vladimir Gushchin Sergey Netesov Lars O. Magnius Heléne Norder agris 2022-11-07 application/pdf https://doi.org/10.3390/v14112465 EN eng Multidisciplinary Digital Publishing Institute Human Virology and Viral Diseases https://dx.doi.org/10.3390/v14112465 https://creativecommons.org/licenses/by/4.0/ Viruses; Volume 14; Issue 11; Pages: 2465 hepatitis B virus genotypes subgenotypes HBsAg subtypes molecular epidemiology Siberia Siberian natives aboriginal population Text 2022 ftmdpi https://doi.org/10.3390/v14112465 2023-08-01T07:14:05Z A total of 381 hepatitis B virus (HBV) DNA sequences collected from nine groups of Siberian native populations were phylogenetically analyzed along with 179 HBV strains sampled in different urban populations of former western USSR republics and 50 strains from Central Asian republics and Mongolia. Different HBV subgenotypes predominated in various native Siberian populations. Subgenotype D1 was dominant in Altaian Kazakhs (100%), Tuvans (100%), and Teleuts (100%) of southern Siberia as well as in Dolgans and Nganasans (69%), who inhabit the polar Taimyr Peninsula. D2 was the most prevalent subgenotype in the combined group of Nenets, Komi, and Khants of the northern Yamalo-Nenets Autonomous Region (71%) and in Yakuts (36%) from northeastern Siberia. D3 was the main subgenotype in South Altaians (76%) and Buryats (40%) of southeastern Siberia, and in Chukchi (51%) of the Russian Far East. Subgenotype C2 was found in Taimyr (19%) and Chukchi (27%), while subgenotype A2 was common in Yakuts (33%). In contrast, D2 was dominant (56%) in urban populations of the former western USSR, and D1 (62%) in Central Asian republics and Mongolia. Statistical analysis demonstrated that the studied groups are epidemiologically isolated from each other and might have contracted HBV from different sources during the settlement of Siberia. Text Chukchi nenets Nganasan* Taimyr Yakuts Yamalo Nenets Siberia MDPI Open Access Publishing Viruses 14 11 2465 |
institution |
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MDPI Open Access Publishing |
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ftmdpi |
language |
English |
topic |
hepatitis B virus genotypes subgenotypes HBsAg subtypes molecular epidemiology Siberia Siberian natives aboriginal population |
spellingShingle |
hepatitis B virus genotypes subgenotypes HBsAg subtypes molecular epidemiology Siberia Siberian natives aboriginal population Victor Manuylov Vladimir Chulanov Ludmila Bezuglova Elena Chub Anastasia Karlsen Karen Kyuregyan Yulia Ostankova Alexander Semenov Ludmila Osipova Tatjana Tallo Irina Netesova Artem Tkachuk Vladimir Gushchin Sergey Netesov Lars O. Magnius Heléne Norder Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives |
topic_facet |
hepatitis B virus genotypes subgenotypes HBsAg subtypes molecular epidemiology Siberia Siberian natives aboriginal population |
description |
A total of 381 hepatitis B virus (HBV) DNA sequences collected from nine groups of Siberian native populations were phylogenetically analyzed along with 179 HBV strains sampled in different urban populations of former western USSR republics and 50 strains from Central Asian republics and Mongolia. Different HBV subgenotypes predominated in various native Siberian populations. Subgenotype D1 was dominant in Altaian Kazakhs (100%), Tuvans (100%), and Teleuts (100%) of southern Siberia as well as in Dolgans and Nganasans (69%), who inhabit the polar Taimyr Peninsula. D2 was the most prevalent subgenotype in the combined group of Nenets, Komi, and Khants of the northern Yamalo-Nenets Autonomous Region (71%) and in Yakuts (36%) from northeastern Siberia. D3 was the main subgenotype in South Altaians (76%) and Buryats (40%) of southeastern Siberia, and in Chukchi (51%) of the Russian Far East. Subgenotype C2 was found in Taimyr (19%) and Chukchi (27%), while subgenotype A2 was common in Yakuts (33%). In contrast, D2 was dominant (56%) in urban populations of the former western USSR, and D1 (62%) in Central Asian republics and Mongolia. Statistical analysis demonstrated that the studied groups are epidemiologically isolated from each other and might have contracted HBV from different sources during the settlement of Siberia. |
format |
Text |
author |
Victor Manuylov Vladimir Chulanov Ludmila Bezuglova Elena Chub Anastasia Karlsen Karen Kyuregyan Yulia Ostankova Alexander Semenov Ludmila Osipova Tatjana Tallo Irina Netesova Artem Tkachuk Vladimir Gushchin Sergey Netesov Lars O. Magnius Heléne Norder |
author_facet |
Victor Manuylov Vladimir Chulanov Ludmila Bezuglova Elena Chub Anastasia Karlsen Karen Kyuregyan Yulia Ostankova Alexander Semenov Ludmila Osipova Tatjana Tallo Irina Netesova Artem Tkachuk Vladimir Gushchin Sergey Netesov Lars O. Magnius Heléne Norder |
author_sort |
Victor Manuylov |
title |
Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives |
title_short |
Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives |
title_full |
Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives |
title_fullStr |
Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives |
title_full_unstemmed |
Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives |
title_sort |
genetic diversity and possible origins of the hepatitis b virus in siberian natives |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2022 |
url |
https://doi.org/10.3390/v14112465 |
op_coverage |
agris |
genre |
Chukchi nenets Nganasan* Taimyr Yakuts Yamalo Nenets Siberia |
genre_facet |
Chukchi nenets Nganasan* Taimyr Yakuts Yamalo Nenets Siberia |
op_source |
Viruses; Volume 14; Issue 11; Pages: 2465 |
op_relation |
Human Virology and Viral Diseases https://dx.doi.org/10.3390/v14112465 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/v14112465 |
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Viruses |
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14 |
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11 |
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2465 |
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