Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s Dynamics
The emergence of SARS-CoV-2 variants, as observed with the D614G spike protein mutant and, more recently, with B.1.1.7 (501Y.V1), B.1.351 (501Y.V2) and B.1.1.28.1 (P.1) lineages, represent a continuous threat and might lead to strains of higher infectivity and/or virulence. We report on the occurren...
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ftmdpi:oai:mdpi.com:/1999-4915/13/5/883/ 2023-08-20T04:01:22+02:00 Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s Dynamics Jorge González-Puelma Jacqueline Aldridge Marco Montes de Oca Mónica Pinto Roberto Uribe-Paredes José Fernández-Goycoolea Diego Alvarez-Saravia Hermy Álvarez Gonzalo Encina Thomas Weitzel Rodrigo Muñoz Álvaro Olivera-Nappa Sergio Pantano Marcelo A. Navarrete agris 2021-05-11 application/pdf https://doi.org/10.3390/v13050883 EN eng Multidisciplinary Digital Publishing Institute SARS-CoV-2 and COVID-19 https://dx.doi.org/10.3390/v13050883 https://creativecommons.org/licenses/by/4.0/ Viruses; Volume 13; Issue 5; Pages: 883 SARS-CoV2 variant Covid19 Text 2021 ftmdpi https://doi.org/10.3390/v13050883 2023-08-01T01:41:24Z The emergence of SARS-CoV-2 variants, as observed with the D614G spike protein mutant and, more recently, with B.1.1.7 (501Y.V1), B.1.351 (501Y.V2) and B.1.1.28.1 (P.1) lineages, represent a continuous threat and might lead to strains of higher infectivity and/or virulence. We report on the occurrence of a SARS-CoV-2 haplotype with nine mutations including D614G/T307I double-mutation of the spike. This variant expanded and completely replaced previous lineages within a short period in the subantarctic Magallanes Region, southern Chile. The rapid lineage shift was accompanied by a significant increase of cases, resulting in one of the highest incidence rates worldwide. Comparative coarse-grained molecular dynamic simulations indicated that T307I and D614G belong to a previously unrecognized dynamic domain, interfering with the mobility of the receptor binding domain of the spike. The T307I mutation showed a synergistic effect with the D614G. Continuous surveillance of new mutations and molecular analyses of such variations are important tools to understand the molecular mechanisms defining infectivity and virulence of current and future SARS-CoV-2 strains. Text Antarc* Antarctic MDPI Open Access Publishing Antarctic Magallanes ENVELOPE(-62.933,-62.933,-64.883,-64.883) The Spike ENVELOPE(-37.317,-37.317,-54.017,-54.017) Viruses 13 5 883 |
institution |
Open Polar |
collection |
MDPI Open Access Publishing |
op_collection_id |
ftmdpi |
language |
English |
topic |
SARS-CoV2 variant Covid19 |
spellingShingle |
SARS-CoV2 variant Covid19 Jorge González-Puelma Jacqueline Aldridge Marco Montes de Oca Mónica Pinto Roberto Uribe-Paredes José Fernández-Goycoolea Diego Alvarez-Saravia Hermy Álvarez Gonzalo Encina Thomas Weitzel Rodrigo Muñoz Álvaro Olivera-Nappa Sergio Pantano Marcelo A. Navarrete Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s Dynamics |
topic_facet |
SARS-CoV2 variant Covid19 |
description |
The emergence of SARS-CoV-2 variants, as observed with the D614G spike protein mutant and, more recently, with B.1.1.7 (501Y.V1), B.1.351 (501Y.V2) and B.1.1.28.1 (P.1) lineages, represent a continuous threat and might lead to strains of higher infectivity and/or virulence. We report on the occurrence of a SARS-CoV-2 haplotype with nine mutations including D614G/T307I double-mutation of the spike. This variant expanded and completely replaced previous lineages within a short period in the subantarctic Magallanes Region, southern Chile. The rapid lineage shift was accompanied by a significant increase of cases, resulting in one of the highest incidence rates worldwide. Comparative coarse-grained molecular dynamic simulations indicated that T307I and D614G belong to a previously unrecognized dynamic domain, interfering with the mobility of the receptor binding domain of the spike. The T307I mutation showed a synergistic effect with the D614G. Continuous surveillance of new mutations and molecular analyses of such variations are important tools to understand the molecular mechanisms defining infectivity and virulence of current and future SARS-CoV-2 strains. |
format |
Text |
author |
Jorge González-Puelma Jacqueline Aldridge Marco Montes de Oca Mónica Pinto Roberto Uribe-Paredes José Fernández-Goycoolea Diego Alvarez-Saravia Hermy Álvarez Gonzalo Encina Thomas Weitzel Rodrigo Muñoz Álvaro Olivera-Nappa Sergio Pantano Marcelo A. Navarrete |
author_facet |
Jorge González-Puelma Jacqueline Aldridge Marco Montes de Oca Mónica Pinto Roberto Uribe-Paredes José Fernández-Goycoolea Diego Alvarez-Saravia Hermy Álvarez Gonzalo Encina Thomas Weitzel Rodrigo Muñoz Álvaro Olivera-Nappa Sergio Pantano Marcelo A. Navarrete |
author_sort |
Jorge González-Puelma |
title |
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s Dynamics |
title_short |
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s Dynamics |
title_full |
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s Dynamics |
title_fullStr |
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s Dynamics |
title_full_unstemmed |
Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s Dynamics |
title_sort |
mutation in a sars-cov-2 haplotype from sub-antarctic chile reveals new insights into the spike’s dynamics |
publisher |
Multidisciplinary Digital Publishing Institute |
publishDate |
2021 |
url |
https://doi.org/10.3390/v13050883 |
op_coverage |
agris |
long_lat |
ENVELOPE(-62.933,-62.933,-64.883,-64.883) ENVELOPE(-37.317,-37.317,-54.017,-54.017) |
geographic |
Antarctic Magallanes The Spike |
geographic_facet |
Antarctic Magallanes The Spike |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Viruses; Volume 13; Issue 5; Pages: 883 |
op_relation |
SARS-CoV-2 and COVID-19 https://dx.doi.org/10.3390/v13050883 |
op_rights |
https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/v13050883 |
container_title |
Viruses |
container_volume |
13 |
container_issue |
5 |
container_start_page |
883 |
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1774724661774385152 |